The distribution of urate deposition within the extremities in gout: a review of 148 dual-energy CT cases

Mallinson, Paul I.; Reagan, Adrian C.; Coupal, Tyler M.; Munk, Peter L.; Ouellette, Hugue A.; Nicolaou, Savvas

doi:10.1007/s00256-013-1771-8

Cited by 71 publications

(59 citation statements)

References 22 publications

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“…Contrary to our hypothesis, our results indicate that the dorsiflexors of the ankle are not affected by strength deficits to the same extent as the plantarflexors of the ankle in people with gout. This finding may be related to the pattern of crystal deposition and patient symptoms reported in the foot and ankle, in which anterior ankle structures, including the tibialis anterior tendon are less frequently involved compared with the posterior ankle and Achilles tendon [6,8]. Our results are consistent with previous studies investigating the ankle in other chronic inflammatory arthritic conditions [27] in which neural…”

Section: Discussionsupporting

confidence: 90%

“…Previous research has observed tophaceous deposition in the Achilles, peroneal and the tibialis posterior muscle tendons in people with gout [6,8]. Tendons have important functional roles, both in generating and absorbing mechanical work during ambulation [19].…”

Section: Discussionmentioning

confidence: 99%

“…The structures of the foot and ankle are frequently affected in people with gout [4,5]. Furthermore, imaging studies have demonstrated particular patterns of foot involvement in gout in which the most common sites for MSU deposition are the first metatarsophalangeal joint, ankle joint and tendons surrounding the ankle including the peroneal and Achilles tendons [6][7][8].…”

Section: Introductionmentioning

confidence: 99%

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Foot and ankle muscle strength in people with gout: A two-arm cross-sectional study

Stewart

Mawston

Davidtz

et al. 2016

Clinical Biomechanics

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Foot and ankle muscle strength in people with gout: a two-arm cross-sectional study, Clinical Biomechanics (2015Biomechanics ( ), doi: 10.1016Biomechanics ( /j.clinbiomech.2015 This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. A C C E P T E D M A N U S C R I P T ACCEPTED MANUSCRIPT A C C E P T E D M A N U S C R I P T ACCEPTED MANUSCRIPT ABSTRACTBackground Foot and ankle structures are the most commonly affected in people with gout.However, the effect of gout on foot and ankle muscle strength is not well understood. The primary aim of this study was to determine whether differences exist in foot and ankle muscle strength for ankle plantarflexion, dorsiflexion, inversion and eversion between people with gout and age-and sex-matched controls. The secondary aim was to determine whether foot and ankle muscle strength was correlated with foot pain and disability.Methods Peak isokinetic concentric muscle torque was measured for ankle plantarflexion, dorsiflexion, eversion and inversion in 20 participants with gout and 20 matched controls at two testing velocities (30°/s and 120°/s) using a Biodex dynamometer. Foot pain and disability was measured using the Manchester Foot Pain and Disability Index (MFPDI).Findings Participants with gout demonstrated reduced muscle strength at both the 30°/s and 120°/s testing velocities for plantarflexion, inversion and eversion (p<0.05). People with gout also displayed a reduced plantarflexion-to-dorsiflexion strength ratio at both 30 o /s and 120 o /s (p<0.05). Foot pain and disability was higher in people with gout (p<0.0001) and MFPDI scores were inversely correlated with plantarflexion and inversion muscle strength at the 30°/s testing velocity, and plantarflexion, inversion and eversion muscle strength at the 120°/s testing velocity (all p<0.05).Interpretation People with gout have reduced foot and ankle muscle strength and experience greater foot pain and disability compared to controls. Foot and ankle strength reductions are strongly associated with increased foot pain and disability in people with gout.

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Section: Discussionsupporting

confidence: 90%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Foot and ankle muscle strength in people with gout: A two-arm cross-sectional study

Stewart

Mawston

Davidtz

et al. 2016

Clinical Biomechanics

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“…DECT provided important insights, particularly into the pathology of gout. The distribution of urate deposits within the extremities of patients with suspected gout was evaluated in an observational study, which found urate deposition in foot (56.1%), in knee (53.4%), in ankle (27.7%), in elbow (16.9%), and in hand and wrist (16.9%), respectively (45).…”

Section: Imaging Techniques In Goutmentioning

confidence: 99%

An old disease with new insights: Update on diagnosis and treatment of gout

Bıtık

2014

Eur J Rheumatol

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Gout is an acute and chronic inflammatory disorder associated with high morbidity and impaired quality of life. There has been a substantial increase in the prevalence and incidence of gout in recent years. Novel diagnostic and therapeutic options have provided new insights into the pathogenesis and management of hyperuricemia and gout in the last decade. This clinical review aims to summarize the diagnostic process and management of acute and chronic gout.

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“…The common sites involved in knee are the popliteus tendon, cruciate ligaments, and quadriceps tendon. 2 Although patellar tendon has been mentioned as a possible involvement site, to our knowledge, only three case reports exist in the literature, two of which were reported in triathletes mimicking patellar tendonitis precipitated due to prolonged exercises. [3][4][5] In this article, we report a 34-year-old male patient with eight years history of gout who presented with one week history of pain and swelling of extremities.…”

mentioning

confidence: 99%

Unusual Presentation of Gout: Intratendinous Tophus in the Patellar Tendon

2016

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The distribution of urate deposition within the extremities in gout: a review of 148 dual-energy CT cases

Abstract: In this observational study, we provide for the first time a detailed analysis of extremity urate distribution in gout, which both supports and augments to the current understanding based on clinical and microscopic findings.

Cited by 71 publications

References 22 publications

Foot and ankle muscle strength in people with gout: A two-arm cross-sectional study

Foot and ankle muscle strength in people with gout: A two-arm cross-sectional study

An old disease with new insights: Update on diagnosis and treatment of gout

Unusual Presentation of Gout: Intratendinous Tophus in the Patellar Tendon

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