The Diverse Bioactivity of α-mangostin and Its Therapeutic Implications

Chavan, Tejashri; Muth, Aaron

doi:10.4155/fmc-2021-0146

Cited by 18 publications

(12 citation statements)

References 93 publications

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“…α-Mangostin is a natural xanthone product isolated from the pericarps of the mangosteen tree as a secondary metabolite, representing one of the most studied chemopreventive agents. 115 Substantial evidence suggests that α-mangostin can interfere with the major stages of carcinogenesis (initiation, promotion, and progression). 116 , 117 Moreover, α-Mangostin exhibits a novel biological function against inflammation in various inflammatory diseases.…”

Section: Potential Therapeutic Strategies For Ivdd Via Targeting Pyro...mentioning

confidence: 99%

Pyroptosis and Intervertebral Disc Degeneration: Mechanistic Insights and Therapeutic Implications

Ge¹,

Chen²,

Guo³

et al. 2022

JIR

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Low back pain (LBP) is a common problem worldwide, resulting in great patient suffering and great challenges for the social health system. Intervertebral disc (IVD) degeneration (IVDD) is widely acknowledged as one of the key causes of LBP. Accumulating evidence suggests that aberrant pyroptosis of IVD cells is involved in the pathogenesis of IVDD progression, however, the comprehensive roles of pyroptosis in IVDD have not been fully established, leaving attempts to treat IVDD with anti-pyroptosis approaches questionable. In this review, we summarize the characteristics of pyroptosis and emphasize the effects of IVD cell pyroptosis on the pathological progression of IVDD, including secretion of cytokines, nucleus pulposus cell apoptosis and autophagy, accelerated extracellular matrix degradation, annulus fibrosus rupture, cartilage endplate calcification, vascularization, sensory and sympathetic fiber neoinnervation, and infiltrating lymphatic vessels. Finally, we discuss several interventions used to treat IVDD by targeting pyroptosis. This review provides novel insights into the crucial role of IVD cell pyroptosis in IVDD pathogenesis, and could be informative for developing novel therapeutic approaches for IVDD and LBP.

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Section: Potential Therapeutic Strategies For Ivdd Via Targeting Pyro...mentioning

confidence: 99%

Pyroptosis and Intervertebral Disc Degeneration: Mechanistic Insights and Therapeutic Implications

Ge¹,

Chen²,

Guo³

et al. 2022

JIR

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“…[17] Among various xanthone derivatives, α-mangostin (MN) is the major one possessing a wide range of biological properties. [18] Even though several reports are available on the biological (pharmacological) applications of MN, its optoelectronic properties are less explored. In this paper, we have exploited the fluorescence quenching interaction of GQDs with MN as a tool for the detection of carbofuran.…”

Section: Introductionmentioning

confidence: 99%

“…The pericarp of mangosteen fruit contains a variety of secondary metabolites such as prenylated and oxygenated xanthones [17] . Among various xanthone derivatives, α‐mangostin ( MN ) is the major one possessing a wide range of biological properties [18] . Even though several reports are available on the biological (pharmacological) applications of MN , its optoelectronic properties are less explored.…”

Section: Introductionmentioning

confidence: 99%

Graphene Quantum Dots Derived from Honey and Mangostin as Sustainable Materials to Construct Fluorescence Turn‐On Molecular Switches for Pesticide Detection

Lekshmi¹,

Swathy²,

Vijayan³

et al. 2023

ChemistrySelect

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Extensive use of pesticides in agriculture can lead to environmental pollution and potentially adverse health effects. A fluorescence Turn‐On molecular switch, derived from naturally occurring α‐mangostin (MN), isolated from the pericarp of mangosteen fruit and Graphene Quantum Dots (GQDs) synthesized from honey, was developed for the detection of carbofuran‐an organic toxic carbamate pesticide. GQDs derived from honey shows a strong fluorescence emission centered at 430 nm, which was efficiently quenched by the addition of MN. The quenching of fluorescence of GQDs by the addition of MN (OFF state) and the regaining of quenched fluorescence of GQDs‐MN system (ON state) upon the addition of the pesticide carbofuran was utilized as a detection strategy for the toxic pesticide carbofuran.

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“…Sanguinarine, (R)-Shikonin, Tanshinone IIA, Honokiol, and α-Mangostin are all natural compounds that have been isolated from the plant species Sanguinaria canadensis , Lithospermum erythrorhizon , Salvia miltiorrhiza , Magnolia officinalis , and Garcinia mangostana , respectively [ 24 , 25 , 26 , 27 , 28 ]. Fisetin is a flavonoid that has been isolated from different plant species in the Fabaceae and Anarcadiaceae families, as well as in several comestible fruits [ 29 ].…”

Section: Introductionmentioning

confidence: 99%

Honokiol and Alpha-Mangostin Inhibit Mayaro Virus Replication through Different Mechanisms

et al. 2022

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Mayaro virus (MAYV) is an emerging arbovirus with an increasing circulation across the Americas. In the present study, we evaluated the potential antiviral activity of the following natural compounds against MAYV and other arboviruses: Sanguinarine, (R)-Shikonin, Fisetin, Honokiol, Tanshinone IIA, and α-Mangostin. Sanguinarine and Shikonin showed significant cytotoxicity, whereas Fisetin, Honokiol, Tanshinone IIA, and α-Mangostin were well tolerated in all the cell lines tested. Honokiol and α-Mangostin treatment protected Vero-E6 cells against MAYV-induced damage and resulted in a dose-dependent reduction in viral progeny yields for each of the MAYV strains and human cell lines assessed. These compounds also reduced MAYV viral RNA replication in HeLa cells. In addition, Honokiol and α-Mangostin disrupted MAYV infection at different stages of the virus life cycle. Moreover, Honokiol and α-Mangostin decreased Una, Chikungunya, and Zika viral titers and downmodulated the expression of E1 and nsP1 viral proteins from MAYV, Una, and Chikungunya. Finally, in Honokiol- and α-Mangostin-treated HeLa cells, we observed an upregulation in the expression of type I interferon and specific interferon-stimulated genes, including IFNα, IFNβ, MxA, ISG15, OAS2, MDA-5, TNFα, and IL-1β, which may promote an antiviral cellular state. Our results indicate that Honokiol and α-Mangostin present potential broad-spectrum activity against different arboviruses through different mechanisms.

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The Diverse Bioactivity of α-mangostin and Its Therapeutic Implications

Cited by 18 publications

References 93 publications

Pyroptosis and Intervertebral Disc Degeneration: Mechanistic Insights and Therapeutic Implications

Pyroptosis and Intervertebral Disc Degeneration: Mechanistic Insights and Therapeutic Implications

Graphene Quantum Dots Derived from Honey and Mangostin as Sustainable Materials to Construct Fluorescence Turn‐On Molecular Switches for Pesticide Detection

Honokiol and Alpha-Mangostin Inhibit Mayaro Virus Replication through Different Mechanisms

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