The diverse landscape of memory T‐cell heterogeneity

Abstract

The immune system remembers in different ways. Immune responses can be generated to the diverse antigens which enter our body through barrier sites-to multifarious infectious pathogens each with specific cellular targets, modes of infection, and persistence. Immunological memory that results from these distinct insults is heterogeneous as manifested by memory T cells. Memory T cells persist in multiple subsets that differ in migration, functional potential, turnover, persistence, and tissue localization, among other things. 1,2 While memory T cells can direct protective responses to numerous pathogens-including viruses, bacteria, fungi, and para-