The Diverse Range of Possible Cell Membrane Interactions with Substrates: Drug Delivery, Interfaces and Mobility

Jang, Hyunsook

doi:10.3390/molecules22122197

Cited by 13 publications

(4 citation statements)

References 122 publications

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“…In the middle range that is comparable to the thickness of the cell membrane lies the boundary between permeation (direction translocation) and endocytosis. Protein is in such a size range (from 3 nm to 20 nm) and demonstrates complex interactions with cell membranes 18,19 . Nanoparticles within such size range (~10 nm) show interesting interactions with cell membranes 20 .…”

Section: Resultsmentioning

confidence: 99%

Understanding the synergistic effect of physicochemical properties of nanoparticles and their cellular entry pathways

et al. 2020

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Gaining precise control over the cellular entry pathway of nanomaterials is key in achieving cytosolic delivery, accessing subcellular environments, and regulating toxicity. However, this precise control requires a fundamental understanding of the behavior of nanomaterials at the bio-nano interface. Herein, we report a computational study investigating the synergistic effect of several key physicochemical properties of nanomaterials on their cellular entry pathways. By examining interactions between monolayer-protected nanoparticles and model cell membranes in a three-dimensional parameter space of size, surface charge/pKa, and ligand chemistry, we observed four different types of nanoparticle translocation for cellular entry which are: outer wrapping, free translocation, inner attach, and embedment. Nanoparticle size, surface charge/pKa, and ligand chemistry each play a unique role in determining the outcome of translocation. Specifically, membrane local curvature induced by nanoparticles upon contact is critical for initiating the translocation process. A generalized paradigm is proposed to describe the fundamental mechanisms underlying the bio-nano interface.

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Section: Resultsmentioning

confidence: 99%

Understanding the synergistic effect of physicochemical properties of nanoparticles and their cellular entry pathways

et al. 2020

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“…Furthermore, the antimicrobial activity of GA (15:1) can be neutralized by all kinds of phospholipids (PG, PE, CL) in the bacterial membrane. Bacterial membranes are important in maintaining bacterial homeostasis and material transport. , The membrane is a prospective target for the screening of antibacterial agents. Antibacterial agents that target bacterial membranes break down bacteria quickly and with limited drug resistance .…”

Section: Discussionmentioning

confidence: 99%

In Vitro, In Vivo, and In Silico Activities of Ginkgolic Acid C15:1 against Streptococcus agalactiae Clinical Isolates

Wen,

Wang,

Bai

et al. 2023

ACS Infect. Dis.

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Streptococcus agalactiae is the major cause of invasive neonatal infections and is a recognized pathogen associated with various diseases in nonpregnant adults. The emergence and spread of antibiotic-resistant S. agalactiae necessitate the development of a novel antibacterial agent. Here, the potential antibacterial activities and mechanisms of ginkgolic acid C15:1 (GA (15:1)) from Ginkgo biloba against clinical S. agalactiae are characterized. The MIC 50 and MIC 90 values for GA (15:1) against 72 clinical S. agalactiae isolates were 6.25 and 12.5 μM, respectively. GA (15:1) showed a strong bactericidal effect against both planktonic bacteria and bacteria embedded in biofilms as well as significant effectiveness in suppressing the growth of S. agalactiae biofilms. Moreover, GA (15:1) possesses intracellular antibacterial activity and could significantly decrease the bacterial burden in the intraperitoneal infection model of S. agalactiae. Mechanistic studies showed that GA (15:1) triggers membrane damage of S. agalactiae through a unique dual-targeting mechanism of action (MoA). First, GA (15:1) targets phospholipids in the bacterial cytoplasmic membrane. Second, by using mass-spectrometry-based drug affinity responsive target stability (DARTS) and molecular docking, lipoprotein signaling peptidase II (lspA) was identified as a target protein of GA (15:1), whose role is crucial for maintaining bacterial membrane depolarization and permeabilization. Our findings suggest a potential therapeutic strategy for developing GA (15:1) to combat S. agalactiae infections.

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“…To further improve understanding of engineered tissues sensor integrated organ-on-chip device (OOC) device was created to characterize membrane stiffness more fully. Membrane stiffness, whether for engineered body tissue or substrates used in device fabrication, is an extremely important physical characteristic as it affects many environmental factors and cellular interactions [ 51 , 52 ]. It also contributes to mechanical properties, such as in extracellular stiffness in morphogenesis [ 53 ], cell differentiation [ 54 ], and proliferation [ 55 ], as well as in the processes of tumor metastasis [ 56 ].…”

Section: Specific Sensorsmentioning

confidence: 99%

Advancement of Sensor Integrated Organ-on-Chip Devices

Clarke

Hartse

Asli

et al. 2021

Sensors

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Organ-on-chip devices have provided the pharmaceutical and tissue engineering worlds much hope since they arrived and began to grow in sophistication. However, limitations for their applicability were soon realized as they lacked real-time monitoring and sensing capabilities. The users of these devices relied solely on endpoint analysis for the results of their tests, which created a chasm in the understanding of life between the lab the natural world. However, this gap is being bridged with sensors that are integrated into organ-on-chip devices. This review goes in-depth on different sensing methods, giving examples for various research on mechanical, electrical resistance, and bead-based sensors, and the prospects of each. Furthermore, the review covers works conducted that use specific sensors for oxygen, and various metabolites to characterize cellular behavior and response in real-time. Together, the outline of these works gives a thorough analysis of the design methodology and sophistication of the current sensor integrated organ-on-chips.

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The Diverse Range of Possible Cell Membrane Interactions with Substrates: Drug Delivery, Interfaces and Mobility

Cited by 13 publications

References 122 publications

Understanding the synergistic effect of physicochemical properties of nanoparticles and their cellular entry pathways

Understanding the synergistic effect of physicochemical properties of nanoparticles and their cellular entry pathways

In Vitro, In Vivo, and In Silico Activities of Ginkgolic Acid C15:1 against Streptococcus agalactiae Clinical Isolates

Advancement of Sensor Integrated Organ-on-Chip Devices

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