The diverse role of corticotropin-releasing factor (CRF) and its CRF1 and CRF2 receptors under pathophysiological conditions: Insights into stress/anxiety, depression, and brain injury processes

Domin, Helena; Śmiałowska, Maria

doi:10.1016/j.neubiorev.2024.105748

Neuroscience & Biobehavioral Reviews

2024

DOI: 10.1016/j.neubiorev.2024.105748

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The diverse role of corticotropin-releasing factor (CRF) and its CRF1 and CRF2 receptors under pathophysiological conditions: Insights into stress/anxiety, depression, and brain injury processes

Helena Domin,

Maria Śmiałowska

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Cited by 2 publications

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Anxiety and depressive disorders in patients with primary painful bladder syndrome. Part 1: Symptoms and clinical progression

Karavaeva,

Vasileva,

Kuzmin

et al. 2024

Urology reports (St. - Petersburg)

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The article is dedicated to affective disorders developing in patients with primary painful bladder syndrome. The causes of their development and influence on the quality of patients’ life are considered. An overview of the etiopathogenic links between anxiety and depressive disorders and bladder pain is presented. it should be noted that common comorbidity with depressive and anxiety disorders is a risk factor for the unfavorable course and chronicity of pain conditions that requires to involve a psychotherapist or psychiatrist for examination and treatment of patients with primary painful bladder syndrome, and, if the somatoform nature of primary painful bladder syndrome is found, for prescribing relevant drug and non-drug treatment.

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Anxiety and depressive disorders in patients with primary painful bladder syndrome. Part 1: Symptoms and clinical progression

Karavaeva,

Vasileva,

Kuzmin

et al. 2024

Urology reports (St. - Petersburg)

View full text Add to dashboard Cite

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A systematic scoping review of the multifaceted role of phoenixin in metabolism: insights from in vitro and in vivo studies

Muzammil,

Barathan,

Yazid

et al. 2024

Front. Endocrinol.

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Phoenixin (PNX) is an emerging neuropeptide that plays a significant role in regulating metabolism and reproduction. This comprehensive review examines findings from human, in vivo, and in vitro studies to elucidate the functions of PNX in metabolic processes. PNX has been identified as a key player in essential metabolic pathways, including energy homeostasis, glucose, lipid and electrolyte metabolism, and mitochondrial dynamics. It modulates food and fluid intake, influences glucose and lipid profiles, and affects mitochondrial biogenesis and function. PNX is abundantly expressed in the hypothalamus, where it plays a crucial role in regulating reproductive hormone secretion and maintaining energy balance. Furthermore, PNX is also expressed in peripheral tissues such as the heart, spleen, and pancreas, indicating its involvement in the regulation of metabolism across central and peripheral systems. PNX is a therapeutic peptide that operates through the G protein-coupled receptor 173 (GPR173) at the molecular level. It activates signaling pathways such as cAMP-protein kinase A (PKA) and Epac-ERK, which are crucial for metabolic regulation. Research suggests that PNX may be effective in managing metabolic disorders like obesity and type 2 diabetes, as well as reproductive health issues like infertility. Since metabolic processes are closely linked to reproduction, further understanding of PNX’s role in these areas is necessary to develop effective management/treatments. This review aims to highlight PNX’s involvement in metabolism and identify gaps in current knowledge regarding its impact on human health. Understanding the mechanisms of PNX’s action is crucial for the development of novel therapeutic strategies for the treatment of metabolic disorders and reproductive health issues, which are significant public health concerns globally.

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The diverse role of corticotropin-releasing factor (CRF) and its CRF1 and CRF2 receptors under pathophysiological conditions: Insights into stress/anxiety, depression, and brain injury processes

Cited by 2 publications

References 149 publications

Anxiety and depressive disorders in patients with primary painful bladder syndrome. Part 1: Symptoms and clinical progression

Anxiety and depressive disorders in patients with primary painful bladder syndrome. Part 1: Symptoms and clinical progression

A systematic scoping review of the multifaceted role of phoenixin in metabolism: insights from in vitro and in vivo studies

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