The diversity and utility of arylthiazoline and aryloxazoline siderophores: Challenges of coordination chemistry, biological activity and selected applications

Mular, Andrzej; Piasta, Karolina; Jedyńczuk, Aleksandra; Kamińska, Karolina; Olshvang, Evgenia; Nolte, Nils Metzler; Wojaczyńska, Elżbieta; Kozłowski, Henryk; Gumienna-Kontecka, Elżbieta

doi:10.1016/j.ccr.2023.215551

Cited by 5 publications

(1 citation statement)

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“…Interestingly, though there are several reports where chelating ligands are presented as siderophore mimics, − there are no such reports available where the system picks up iron(III) selectively from an aqueous solution with a mixture of different metal ions and self-separates from the system. On the other hand, in soft materials, only a few examples are reported as siderophore-mimicking gels in terms of binding Fe(III) ions − In this work, we have purposefully designed and synthesized a compound N 2 , N 4 , N 6 -(1,3,5-triazine-2,4,6-triyl)tris(benzene-1,3,5-tricarbohydrazide) CBTC for mimicking the hydroxamate type siderophore.…”

Section: Introductionmentioning

confidence: 99%

A Siderophore Mimicking Gelation Component for Capturing and Self-Separation of Fe(III) from an Aqueous Solution of Mixture of Metal Ions

Munjal,

Kyarikwal,

Sarkar

et al. 2024

Inorg. Chem.

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The carbohydrazide-based gelation component N 2 ,N 4 ,N 6 -(1,3,5-triazine-2,4,6-triyl)tris(benzene-1,3,5-tricarbohydrazide) (CBTC) was synthesized and characterized using various spectroscopic tools. CBTC and trimesic acid (TMA) get selfassembled to form metallogel with Fe 3+ , specifically through various noncovalent interactions in a DMSO and H 2 O mixture. The self-assembly shows remarkable specificity toward Fe(III) among different transition metal salts. It is pertinent to point out that the binding specificity for Fe 3+ can also be found in nature in the form of siderophores, as they are mainly involved in scavenging iron selectively from the surroundings. DFT studies have been used to investigate the possible interaction between the different components of the iron metallogel. To determine the selectivity of CBTC for iron, CBTC, along with trimesic acid, is used to interact with other metal ions, including Fe(III) ions, in a single system. The gelation components CBTC and TMA selectively bind with iron(III), which leads to the formation of metallogel and gets separated as a discrete layer, leaving the other metal ions in the solution. Therefore, CBTC and TMA together show iron-scavenging properties. This selective scavenging property is explored through FE-SEM, XPS, PXRD, IR, and ICP-AES analysis. The FE-SEM analysis shows a flower-petal-like morphology for the Fe(III) metallogel. The resemblance in the CBTC-TMA-Fe metallogel and metallogel obtained from the mixture of different metal salts is established through FE-SEM images and XPS analysis. The release of iron from the metallogel is achieved with the help of ascorbic acid, which converts Fe 3+ to Fe 2+ . In biological systems, iron also gets released similarly from siderophores. This is the first report where the synthesized gelation component CBTC molecule is capable of scavenging out iron in the form of metallogel and self-separating from the aqueous mixture in the presence of various other metal ions.

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