The DNAxs software suite: A three-year retrospective study on the development, architecture, testing and implementation in forensic casework

Slagter, Martin; Kruise, Dennis; Ommen, Larissa van; Hoogenboom, Jerry; Steensma, Kristy; Jong, Jeroen de; Hovers, Pauline; Parag, Raymond; Linden, Jennifer van der; Kneppers, A. L. J.; Benschop, Corina C.G.

doi:10.1016/j.fsir.2021.100212

Cited by 3 publications

(3 citation statements)

References 20 publications

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“…The observed bugs did not have effects on the DNA profile interpretation and/or reported conclusions. Further information on code coverage by testing, bug detection and debugging, but also information on the use of DNAxs (including DNAStatistX and SmartRank) and post-analytical errors in forensic casework can be found in [149]. Further details on the process of software testing can be found in [62], chapter 10.…”

Section: Validation Guidelines For Best Practice and Qualitymentioning

confidence: 99%

A Review of Probabilistic Genotyping Systems: EuroForMix, DNAStatistX and STRmix™

Gill

Benschop

Buckleton

et al. 2021

Genes

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Probabilistic genotyping has become widespread. EuroForMix and DNAStatistX are both based upon maximum likelihood estimation using a γ model, whereas STRmix™ is a Bayesian approach that specifies prior distributions on the unknown model parameters. A general overview is provided of the historical development of probabilistic genotyping. Some general principles of interpretation are described, including: the application to investigative vs. evaluative reporting; detection of contamination events; inter and intra laboratory studies; numbers of contributors; proposition setting and validation of software and its performance. This is followed by details of the evolution, utility, practice and adoption of the software discussed.

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Section: Validation Guidelines For Best Practice and Qualitymentioning

confidence: 99%

A Review of Probabilistic Genotyping Systems: EuroForMix, DNAStatistX and STRmix™

Gill

Benschop

Buckleton

et al. 2021

Genes

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“…This invokes a three-way interpretation: (1) the DNA profile; (2) the cell typing data and 3) the combination aiming to associate donor and cell type. The interpretation of DNA profiles has progressed tremendously through the application of probabilistic software [229][230][231][232][233] that use information on the number of contributors, allele frequencies, peak height, drop-in, dropout, degradation and more to provide a weight of evidence in the form of a likelihood ratio (LR). The LR includes a person of interest under H1 (H2 generally calculates the likelihood for an unknown, unrelated person).…”

Section: Interpretation Of Cell Typing Resultsmentioning

confidence: 99%

On the Identification of Body Fluids and Tissues: A Crucial Link in the Investigation and Solution of Crime

Sijen

Harbison

2021

Genes

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Body fluid and body tissue identification are important in forensic science as they can provide key evidence in a criminal investigation and may assist the court in reaching conclusions. Establishing a link between identifying the fluid or tissue and the DNA profile adds further weight to this evidence. Many forensic laboratories retain techniques for the identification of biological fluids that have been widely used for some time. More recently, many different biomarkers and technologies have been proposed for identification of body fluids and tissues of forensic relevance some of which are now used in forensic casework. Here, we summarize the role of body fluid/ tissue identification in the evaluation of forensic evidence, describe how such evidence is detected at the crime scene and in the laboratory, elaborate different technologies available to do this, and reflect real life experiences. We explain how, by including this information, crucial links can be made to aid in the investigation and solution of crime.

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“…In the past three years, validation studies have been performed with a number of probabilistic genotyping software (PGS) systems including EuroForMix [ 278 ], DNAStatistX [ 279 , 280 ], TrueAllele [ 281 ], STRmix [ 282 ], Statistefix [ 283 ], Mixture Solution [ 284 ], Kongoh [ 285 ], and MaSTR [ 286 , 287 ]. Developers of EuroForMix, DNAStatistX, and STRmix provided a review of these systems [ 288 ].…”

Section: Advancements In Current Practicesmentioning

confidence: 99%

Recent advances in forensic biology and forensic DNA typing: INTERPOL review 2019–2022

Butler

2023

Forensic Science International: Synergy

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The DNAxs software suite: A three-year retrospective study on the development, architecture, testing and implementation in forensic casework

Cited by 3 publications

References 20 publications

A Review of Probabilistic Genotyping Systems: EuroForMix, DNAStatistX and STRmix™

A Review of Probabilistic Genotyping Systems: EuroForMix, DNAStatistX and STRmix™

On the Identification of Body Fluids and Tissues: A Crucial Link in the Investigation and Solution of Crime

Recent advances in forensic biology and forensic DNA typing: INTERPOL review 2019–2022

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