The dom project for the early detection of breast cancer, Utrecht, The Netherlands

Waard, F. de; Collette, H. J. A.; Rombach, J.J.; Halewijn, E.A. Baanders-van; Honing, C.

doi:10.1016/0021-9681(84)90123-1

Cited by 156 publications

(57 citation statements)

References 26 publications

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“…In the main part of this study we used 69 frozen urine samples from women who had participated in the DOM cohort (8). For the DOM study, overnight urine samples were collected, immediately frozen at intake, and questionnaires were filled in between 1974 and 1986.…”

Section: Methodsmentioning

confidence: 99%

Quality and Quantity of DNA Isolated from Frozen Urine in Population-Based Research

Hel

Luijt

Mesquita

et al. 2002

Analytical Biochemistry

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In several population-based studies in the past urine samples were collected and stored for future research. We set out to determine the reliability of using such samples for genotyping DNA markers in epidemiologic research. A source of DNA extracted from exfoliated nucleated cells in urine is provided by the DOM cohort, in which specimens were collected 15-25 years ago. We have examined the quality of the DNA in 48 of these samples by measuring the amount of DNA isolated and its ability to provide an adequate PCR template for amplicons of different lengths. MTHFR polymorphism was analyzed in 644 specimens to determine the inter-and intraobserver reproducibility. Although the DNA amount was variable, 26 to 89% of the samples, depending both on the length of the PCR amplicon and on PCR conditions, yielded a visible PCR product. The intra-and interobserver agreements were comparable ( 0.86 and 0.88, respectively). Our results demonstrate that frozen urine samples can be used for DNA typing studies in women after prolonged periods of storage, but with sometimes unpredictable results. Ultimately, the genotype success rate was 89.3%. Urine collection can be considered as a useful method of obtaining DNA in large cohort studies and other circumstances when blood samples cannot be obtained or have not been stored. © 2002 Elsevier Science (USA)

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Section: Methodsmentioning

confidence: 99%

Quality and Quantity of DNA Isolated from Frozen Urine in Population-Based Research

Hel

Luijt

Mesquita

et al. 2002

Analytical Biochemistry

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“…Estimates of the number and type of these procedures used in the situation without screening were based on the following sources: general practitioners' registry (Trouw, 1986); the radioactivity and radiation application division of the Ministry of Welfare, Health and Cultural Affairs; the Central Office for the Administration of Specialists' Fees (De Waard et al, 1986); and the Steering Committee on Future Health Scenarios (1988).…”

Section: Assessment and Excision Biopsymentioning

confidence: 99%

“…The policy for this treatment was based on a reported file study of 52 patients with breast cancer metastases (De Waard et al, 1986).…”

Section: Assessment and Excision Biopsymentioning

confidence: 99%

Breast cancer screening: its impact on clinical medicine

Koning

Oortmarssen²,

Ineveld³

et al. 1990

Br J Cancer

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Summary Breast cancer screening is generally accepted as an effective means of reducing breast cancer mortality in post-menopausal women. In this analysis the impact of nationwide screening on clinical medicine and the effects for the women involved are quantified. Effect estimates are based on results from screening trials in Utrecht (DOM-project) and Nijmegen, and on bi-annual screening of women aged 50-70. The consequences for health care are based on generally accepted assessment and treatment policies. The number of assessment procedures for non-palpable lesions will increase by 12% per year in the build-up period, and will remain slightly higher. The total number of biopsies in a real population is expected to decrease. Screening will lead to a shift in primary treatment modalities, as 15% of mastectomies will be replaced by breast conserving therapy. The temporary increase in the demand for primary treatment in the first years will be followed by a decrease in the demand for treating women with advanced disease. Favourable effects outweigh the inevitable unfavourable effects, with high quality screening and an appropriate invitation system. Breast cancer screening can also be recommended after considering other consequences than mortality reduction.Several trials have shown that mammographic screening of post-menopausal women reduces breast cancer mortality (Shapiro et al., 1982;Verbeek et al., 1984;Collette et al., 1984;Tabar et al., 1985;UK Trial 1988;Andersson et al., 1988). The introduction of a national programme in the United Kingdom, offering tri-annual screening to women aged 50-65, would result in a mortality reduction of 8% (Knox, 1988). In the Netherlands with bi-annual screening of women aged 50-70, this figure would be 12% (van der Maas et al., 1989).Although mortality reduction is the fundamental effect (Day et al., 1989), there is much debate about other desirable and undesirable consequences of breast cancer screening (Warren, 1988;Skrabanek, 1988). However, publications which quantify these consequences are lacking. Starting to screen will result in a temporary increase in the number of women with newly diagnosed breast cancer. Detecting these cancers at an earlier stage will affect the type of assessment and treatment. Mass screening will also generate referrals of women, who appear to have no breast cancer (false positives) (Forrest, 1986 Assessment and excision biopsyIn assessing breast abnormalities, at least three successive steps were distinguished: physical examination, clinical mammography and excision biopsy (with possible specimen radiography). Additional possibilities which were taken into account for palpable lesions only were fine needle aspiration (cytology) and ultrasound.Estimates of the number and type of these procedures used in the situation without screening were based on the following sources: general practitioners' registry (Trouw, 1986); the radioactivity and radiation application division of the Ministry of Welfare, Health and Cultural Affairs; the Central Office ...

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“…These cancers surface among negative screenees before the next scheduled examination would have taken place. Of all breast cancers in a screened population about 20-35% are diagnosed within 2 years after the last screening examination (Verbeek, 1985;Tabar et al, 1987;Moskowitz, 1986;de Waard et al, 1984; Lundgren, 1979). The survival of patients with interval cancers turned out to be just as bad as the survival of patients diagnosed outside screening programmes (Holmberg et al, 1986;Shapiro et al, 1982).…”

mentioning

confidence: 99%

The occurrence of interval cancers in the Nijmegen screening programme

Peeters

Verbeek²,

Hendriks³

et al. 1989

Br J Cancer

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Summary Since January 1975 a population-based screening programme for the early detection of breast cancer has been carried out in the city of Nijmegen. During five interscreening periods of 2 years each a total of 158 so-called interval cancers were diagnosed. Careful revision of all screening and diagnostic mammograms was executed. Of all interval cancers 26% were 'missed' at the previous screening examination (due to technical or observer error), 16% were radiographically occult at the time of diagnosis and 58% were 'true' interval cancers. Interval cancers were regarded as 'true' when an obvious lesion was observed on the diagnostic mammogram while no suspect signs were seen on the previous screening mammogram. The prevalence of 'missed' cancers did not decline in the course of the screening programme. Radiographically occult tumours were localised, mostly in Wolfe's P2/DY breast parenchyma (83%), 33% were lobular invasive and 25% ductal non-invasive. 'True' interval cancer cases (58%) showed the same overall survival as control breast cancer patients, diagnosed in a non-screening situation. Shortening the screening interval would reduce interval cancer rates and probably further decrease breast cancer mortality in a screened population. However, from the present series of interval cancers 63% would not have been prevented by an annual screening examination. As regards women under age 50 annual screening would still leave 66% of all interval cancers in this age group undetected. Probably more benefit will be gained by searching for new imaging techniques to reduce numbers of 'missed' cancers and to detect lobular invasive and ductal non-invasive cancers in dense breast parenchyma.Within any screening programme for the early detection of breast cancer, women are diagnosed as having so-called interval cancer. These cancers surface among negative screenees before the next scheduled examination would have taken place. Of all breast cancers in a screened population about 20-35% are diagnosed within 2 years after the last screening examination (Verbeek, 1985;Tabar et al., 1987;Moskowitz, 1986;de Waard et al., 1984;Lundgren, 1979). The survival of patients with interval cancers turned out to be just as bad as the survival of patients diagnosed outside screening programmes (Holmberg et al., 1986;Shapiro et al., 1982). This finding would seem to suggest that shortening the screening interval to, say, one year might further decrease breast cancer mortality in a population offered a screening programme. The aim of the present study was to search for more evidence validating such recommendations. It was evaluated whether the number of 'missed' cancers decreased during the 12-year observation period. Interval cancers were compared with breast cancers, detected at one of the five screening rounds, in terms of such radiological and prognostic aspects as Wolfe classification, mammographical tumour size, age at the previous examination, quetelet index, oestrogen receptor positivity and axillary lymph node involvement. To eva...

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The dom project for the early detection of breast cancer, Utrecht, The Netherlands

Cited by 156 publications

References 26 publications

Quality and Quantity of DNA Isolated from Frozen Urine in Population-Based Research

Quality and Quantity of DNA Isolated from Frozen Urine in Population-Based Research

Breast cancer screening: its impact on clinical medicine

The occurrence of interval cancers in the Nijmegen screening programme

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