The Domestic Coalition: The Command and Control Relationship Between Active Component and National Guard Forces in Defense Support of Civil Authorities Operations

Abstract

Public reporting burden for this collection of information is estimated to average 1 hour per response, including the time for reviewing instructions, searching existing data sources, gathering and maintaining the data needed, and completing and reviewing this collection of information. Send comments regarding this burden estimate or any other aspect of this collection of information, including suggestions for reducing this burden to Department of Defense, Washington Headquarters Services, Directorate for Information Operations and Reports (0704-0188), 1215 Jefferson Davis Highway, Suite 1204, Arlington, VA 22202-4302. Respondents should be aware that notwithstanding any other provision of law, no person shall be subject to any penalty for failing to comply with a collection of information if it does not display a currently valid OMB control number. PLEASE DO NOT RETURN YOUR FORM TO THE ABOVE ADDRESS. REPORT DATE 01-09-20072. REPORT TYPE Annual DATES COVERED PERFORMING ORGANIZATION NAME(S) AND ADDRESS(ES) 8. PERFORMING ORGANIZATION REPORT NUMBERUniversity Of California, San Francisco San Francisco, Ca 94143-0962 SPONSORING / MONITORING AGENCY NAME(S) AND ADDRESS(ES) 10. SPONSOR/MONITOR'S ACRONYM(S) U.S. Army Medical Research and Materiel Command Fort Detrick, Maryland 21702-5012 SPONSOR/MONITOR'S REPORT NUMBER(S) DISTRIBUTION / AVAILABILITY STATEMENTApproved for Public Release; Distribution Unlimited SUPPLEMENTARY NOTES ABSTRACTStudies from this grant led to discovery of a new interaction site on the androgen receptor for binding proteins that regulate the function of the receptor. The protein binders have not been identified, but we showed that the site has the characteristics of functioning in repression. We used X-ray crystallography to discover the binding mode of four compounds that bind to this site. Their binding is accompanied by weakening the interaction of the androgen receptor with coactivators as shown by disorder or representative peptides that were well ordered before adding the compounds. Thus, atomic level imaging of these interactions fit with the notion that the site functions in repression, as suggested by analysis of mutations of amino acid residues found in humans in cell and biochemical assays. This work suggests that compounds may be designed to target this site and weaken activity of the androgen receptor. Such compounds could form a new class of chemical therapeutics for treatment of prostate cancer. SUBJECT TERMSX-ray crystallography, high throughput screening, medicinal chemistry (LBD). Unfortunately, in tumor progression secondary events (including AR mutations or modifications and alteration in AR and cofactor levels) sensitize AR action to low androgen or antiandrogen environments, thereby reactivating AR dependent gene expression programs and leading to proliferation of tumors. Eventually these evolve resistance to existing chemotherapeutics that inhibit by competition for the hormone binding pocket. An alternative class of inhibitors, which bind to NR surfaces that mediate ...

Command and Control: Challenging Fallacies of the ‘Military Model’ in Research and Practice

“…During the response to Hurricane Katrina, many viewed support efforts by the Department of Defense and Department of Homeland Security unfavorably. Frequently cited reasons detailing the challenges of the federal response include a lack of communication, failures of coordination, and the legal divide between state and federal chains of command (Apte and Heath 2011;Bentley 2012;Bowman, Kapp, and Belasco 2005;Burke 2016;Burke and McNeil 2015;Burkett 2008;Blum and McIntyre 2012;Dunphy and Radel 2009;Government Accountability Office 2012;Gereski 2006;Ginter et al 2006;Hall 2009;Jensen 2007;McHale 2012;Milliman, Grosskopf, and Paez 2006;Osterholzer 2008;Porter 2010;Prendergast 2011;Prosch 2011;Schwabel 2007;Schumacher 2011;Teague 2007;Tierney, Bevc, and Kuligowski 2006;Topp 2006;Tussing 2011). As a result of the perceived rigidity, according to researchers the military was unable to establish a collaborative environment with state and local responders.…”