The Dopamine Receptor D2 C957T Polymorphism Modulates Early Components of Event-Related Potentials in Visual Word Recognition Task

Abstract

Background: Visual word recognition is one of the central topics in cognitive psychology and cognitive neuroscience. Genetic factors are known to contribute to the visual word recognition, but no genes associated with this process have been identified so far. We studied the impact of the DRD2 C957T polymorphism on the efficiency of visual word recognition by measuring its neuronal correlates and behavioral parameters. Early (~200 ms) components of event-related potentials (ERP) were recorded during a lexical decision task. The DRD2 C957T polymorphism is thought to be associated with D2 receptor’s availability and binding potential. Earlier studies have demonstrated the influence of this variation on perception and processing of verbal stimuli. The DRD2 C957T is also associated with schizophrenia, with the C allele being the risk allele. Methods: Electroencephalogram, genetic, and behavioral data were collected from 96 healthy individuals (53.1% men). ERPs were recorded for words and pseudowords in implicit and explicit tasks. Two regions of interests in the left ventral temporal cortex, whose role in early visual word processing is well established, were selected for analysis. Results: The results showed the main effect of the DRD2 C957T polymorphism on P200 amplitude. Carriers of the TT genotype had higher P200 amplitudes compared to subjects with schizophrenia risk C allele. Within-group comparisons demonstrated a better ability to adjust attention to orthographic stimuli depending on task demands and lexicality in the TT group. Conclusion: The results of the study suggest that the DRD2 C957T polymorphism modulates early stages of visual word recognition.

A review of current research on genetic factors associated with the functioning of the perceptual and emotional systems of the brain

“…Carriers of T/T genotype had higher amplitudes of P200 compared with carriers of the risk allele of schizophrenia C. Intragroup comparisons showed better ability to regulate attention to orthographic stimuli depending on job requirements and lexicality in the T/T group. The results of the study show that the C957T polymorphism of the DRD2 gene modulates the early stages of visual word recognition [1].…”

Psychological and genetic characteristics and strategies of students’ digital behavior in the context of the formation of the digital ecosystem

“…Behavioral genetics has linked specific gene polymorphisms to various behaviors and traits, as well as skills development, emotional responses, and Internet addiction [6,7,8]. For example, the COMT gene's A (Met) allele is associated with increased dopamine levels, stress vulnerability, and effective information processing.…”

Genetic predictors of destructive and constructive types of digital behavior among young people

“…В отношении степени биологической де терминации тех или иных видов активности личности, в том числе информационного по ведения, одним из наиболее информативных является применение молекулярногенетиче ского метода с использованием полимераз ной цепной реакции. Так, известно, что ген COMT содержит множественные однонуклео тидные полиморфизмы, некоторые из кото рых представлены в литературе как имеющие клиническое значение [2,8]. Ген СОМТ также ассоциирован с активностью стриопалли дарной системы и префронтальных отделов, агрессивностью [13], мотивацией, успешно стью распознавания отрицательных эмоций [7].…”

“…Проводилась реги страция ранних (примерно 200 мс) компонент, связанных с событиями потенциалов во вре мя лексического решения задачи. Результаты исследования показывают, что полиморфизм DRD 2 C 957T модулирует ранние стадии визу ального распознавания слов [8].…”