The Dopaminergic Control of Movement-Evolutionary Considerations

Pérez‐Fernández, Juan; Barandela, Marta; Jiménez-López, Cecilia

doi:10.3390/ijms222011284

Cited by 11 publications

(7 citation statements)

References 135 publications

(249 reference statements)

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“…Across the animal kingdom, the dopaminergic system is closely associated with locomotion and the generation of movement [57,58]. In humans, the progressive death of dopaminergic neurons is widely accepted as a cause of Parkinson's disease, which results in difficulties in initiating movement [59][60][61].…”

Section: Activation Of Dopamine Neurons Makes Larvae Stop and Turnmentioning

confidence: 99%

High-resolution analysis of individual Drosophila melanogaster larvae uncovers individual variability in locomotion and its neurogenetic modulation

et al. 2023

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Neuronally orchestrated muscular movement and locomotion are defining faculties of multicellular animals. Due to its simple brain and genetic accessibility, the larva of the fruit fly Drosophila melanogaster allows one to study these processes at tractable levels of complexity. However, although the faculty of locomotion clearly pertains to the individual, most studies of locomotion in larvae use measurements aggregated across animals, or animals tested one by one, an extravagance for larger-scale analyses. This prevents grasping the inter- and intra-individual variability in locomotion and its neurogenetic determinants. Here, we present the IMBA (individual maggot behaviour analyser) for analysing the behaviour of individual larvae within groups, reliably resolving individual identity across collisions. We use the IMBA to systematically describe the inter- and intra-individual variability in locomotion of wild-type animals, and how the variability is reduced by associative learning. We then report a novel locomotion phenotype of an adhesion GPCR mutant. We further investigated the modulation of locomotion across repeated activations of dopamine neurons in individual animals, and the transient backward locomotion induced by brief optogenetic activation of the brain-descending ‘mooncrawler’ neurons. In summary, the IMBA is an easy-to-use toolbox allowing an unprecedentedly rich view of the behaviour and its variability of individual larvae, with utility in multiple biomedical research contexts.

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Section: Activation Of Dopamine Neurons Makes Larvae Stop and Turnmentioning

confidence: 99%

High-resolution analysis of individual Drosophila melanogaster larvae uncovers individual variability in locomotion and its neurogenetic modulation

et al. 2023

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show abstract

“…Across the animal kingdom, the dopaminergic system is closely associated with locomotion and the generation of movement [49,50]. In humans, the progressive death of dopaminergic neurons is widely accepted as a cause of Parkinson's disease, which results in difficulties in initiating movement [51][52][53].…”

Section: Activation Of Dopamine Neurons Makes Larvae Stop and Turnmentioning

confidence: 99%

High-resolution analysis of individualDrosophila melanogasterlarvae within groups uncovers inter- and intra-individual variability in locomotion and its neurogenetic modulation

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Paisios

Stöter

et al. 2022

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Neuronally orchestrated muscular movement and locomotion are defining faculties of multicellular animals. Due to its numerically simple brain and neuromuscular system and its genetic accessibility, the larva of the fruit fly Drosophila melanogaster is an established model to study these processes at tractable levels of complexity. However, although the faculty of locomotion clearly pertains to the individual animal, present studies of locomotion in larval Drosophila mostly use group assays and measurements aggregated across individual animals. The alternative is to measure animals one at a time, an extravagance for larger-scale analyses. In principle or in practice, this in particular rules out grasping the inter- and intra-individual variability in locomotion and its genetic and neuronal determinants. Here we present the IMBA (Individual Maggot Behaviour Analyser) for tracking and analysing the behaviour of individual larvae within groups. Using a combination of computational modelling and statistical approaches, the IMBA reliably resolves individual identity across collisions. It does not require specific hardware and can therefore be used in non-expert labs. We take advantage of the IMBA first to systematically describe the inter- and intra-individual variability in free, unconstrained locomotion in wild-type animals. We then report the discovery of a novel, complex locomotion phenotype of a mutant lacking an adhesion-type GPCR. The IMBA further allows us to determine, at the level of individual animals, the modulation of locomotion across repeated activations of dopamine neurons. Strikingly, IMBA can also be used to analyse 'silly walks', that is patterns of locomotion it was not originally designed to investigate. This is shown for the transient backward locomotion induced by brief optogenetic activation of the brain-descending 'mooncrawler' neurons, and the variability in this behaviour. Thus, the IMBA is an easy-to-use toolbox allowing an unprecedentedly rich view of the behaviour and behavioural variability of individual Drosophila larvae, with utility in multiple biomedical research contexts.

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“…Dopaminergic neurons are involved in a wide range of functions in the central nervous system (CNS), including movement, memory, arousal, and cognition [ 6 , 7 , 8 , 9 ]. Dopamine (DA) is a major neurotransmitter that exerts biological functions by binding to dopamine receptors [ 10 ].…”

Section: Introductionmentioning

confidence: 99%

Dopaminergic System in Promoting Recovery from General Anesthesia

et al. 2023

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Dopamine is an important neurotransmitter that plays a biological role by binding to dopamine receptors. The dopaminergic system regulates neural activities, such as reward and punishment, memory, motor control, emotion, and sleep–wake. Numerous studies have confirmed that the dopaminergic system has the function of maintaining wakefulness in the body. In recent years, there has been increasing evidence that the sleep–wake cycle in the brain has similar neurobrain network mechanisms to those associated with the loss and recovery of consciousness induced by general anesthesia. With the continuous development and innovation of neurobiological techniques, the dopaminergic system has now been proved to be involved in the emergence from general anesthesia through the modulation of neuronal activity. This article is an overview of the dopaminergic system and the research progress into its role in wakefulness and general anesthesia recovery. It provides a theoretical basis for interpreting the mechanisms regulating consciousness during general anesthesia.

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The Dopaminergic Control of Movement-Evolutionary Considerations

Cited by 11 publications

References 135 publications

High-resolution analysis of individual Drosophila melanogaster larvae uncovers individual variability in locomotion and its neurogenetic modulation

High-resolution analysis of individual Drosophila melanogaster larvae uncovers individual variability in locomotion and its neurogenetic modulation

High-resolution analysis of individualDrosophila melanogasterlarvae within groups uncovers inter- and intra-individual variability in locomotion and its neurogenetic modulation

Dopaminergic System in Promoting Recovery from General Anesthesia

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