The dose-effect association between acupuncture sessions and its effects on major depressive disorder: A meta-regression of randomized controlled trials

Xu, Guixing; Lei, Hanzhou; Huang, Liuyang; Xiao, Qiwei; Huang, Biqing; Zhou, Zhuo; Tian, Hao; Huang, Fengyuan; Liu, Yilin; Zhao, Ling; Li, Xiang; Liang, Fanrong

doi:10.1016/j.jad.2022.04.155

Cited by 26 publications

(16 citation statements)

References 32 publications

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“…The subgroup analysis of the treatment course indicated a possible cumulative benefit of the combined therapy, with the prolongation of treatment duration, this suggested the dose-effect relationship of acupuncture combined with balloon dilation, and consistent with the previous study (Peng et al, 2018 ; Li et al, 2022 ; Xu et al, 2022 ). However, we cannot judge the best treatment course because of the limited literature.…”

Section: Discussionsupporting

confidence: 89%

Acupuncture combined with balloon dilation for post-stroke cricopharyngeal achalasia: A meta-analysis of randomized controlled trials

et al. 2023

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BackgroundThe purpose of this study was to systematically evaluate the effectiveness of acupuncture combined with balloon dilatation in patients with post-stroke cricopharyngeal achalasia (CPA) according to the effective rate, videofluoroscopy swallowing study (VFSS) score and standardized swallowing function assessment scale (SSA) score through Meta-analysis.MethodsEnglish and Chinese language literature published before July 24,2022 were searched in ten electronic databases. The identified articles were screened, data were extracted, and the methodological quality of the included trials was assessed. Using RevMan 5.4.1 software to perform Meta-analysis.Results10 studies with 517 patients with post-stroke CPA were included. Meta-analysis showed that the effective rate of the experience group was higher than that of the control group [OR = 0.62; 95% CI (2.32, 13.05); I2 = 0%; p = 0.0001]. Compared to the control group, the SSA score was lower in the experience group [MD = −4.22; 95% CI (−4.57, −3.87); I2 = 42%; p < 0.00001]. In terms of VFSS scores, the experience group showed greater efficacy differences than control group [MD = 1.53; 95% CI (1.32, 1.75); I2 = 0%; p < 0.00001]. The subgroup analysis of VFSS score based on the average course of disease (<1 month vs. ≥1 month) showed no significant difference. The subgroup analysis based on average age (>60 years vs. ≤60 years) showed the VFSS score of the experience group was significantly higher than that of the control group, and the effect may be better in the subgroup older than 60 years. The subgroup analysis based on the treatment course (>30 days vs. ≤30 days) showed the VFSS score of the experience group was significantly higher than that of the control group, and the effect may be better in the subgroup the treatment course>30 days.ConclusionAcupuncture combined with balloon dilatation may be an effective method for treating post-stroke CPA. Compared with balloon dilatation, acupuncture combined with balloon can significantly improve the swallowing function of patients, and it is also effective for patients of different courses, ages, and treatment course, while patients over 60 years old and the treatment course over 30 days may have better clinical outcomes.

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Section: Discussionsupporting

confidence: 89%

Acupuncture combined with balloon dilation for post-stroke cricopharyngeal achalasia: A meta-analysis of randomized controlled trials

et al. 2023

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“…In the measured graph, if the waveform latency exceeded (

\bar x

+ 2s), the amplitude was lower than (

\bar x

+ 2s), or the waveform was missing, it was considered abnormal, whereas other cases were considered normal. (4) Hamilton Anxiety Scale (HAMA) and Hamilton Depression Scale (HAMD) scores (Wang et al., 2021; Xu et al., 2022): The psychological status of anxiety and depression in all patients was evaluated using the HAMA and the HAMD. HAMA consists of 14 items, with each item scored on a 0–4 point 5‐level scale.…”

Section: Methodsmentioning

confidence: 99%

Correlation analysis between cerebral microangiopathy and autonomic nervous dysfunction

Liu,

Wang,

Han

et al. 2024

Brain and Behavior

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ObjectiveOur study was conducted aimed at investigating the potential correlation between cerebral microangiopathy and autonomic nervous dysfunction.MethodsWe initially included 164 hospitalized patients with cerebral microangiopathy at our hospital from November 2019 to January 2021. Based on the inclusion and exclusion criteria, a final total of 162 patients with cerebral microangiopathy were selected. According to the patient's Autonomic Symptom Profile (ASP) score, patients with a score greater than 22 were categorized into a group with concomitant autonomic dysfunction (71 cases, combined group), while those with a score below 22 were categorized into a group of isolated cerebral microangiopathy (83 cases, cerebral microangiopathy group). The general data and laboratory examination results of the two groups were analyzed, and Pearson correlation analysis was performed to evaluate the correlation between cerebral microangiopathy and autonomic dysfunction, as well as the influencing factors of cerebral microangiopathy patients combined with autonomic dysfunction.ResultsThere were no significant differences between the two groups in terms of sex, BMI, smoking, drinking, family dementia history, diabetes, hypothyroidism, carotid atherosclerosis, obstructive sleep apnea hypopnea syndrome, hyperuricemia, hyperlipidemia, chronic obstructive pulmonary disease, Hamilton Anxiety Scale score, Hamilton Depression Scale score, 24‐h mean systolic blood pressure (SBP), 24‐h mean diastolic blood pressure DBP, daytime mean systolic blood pressure (dSBP), daytime mean diastolic blood pressure, nighttime mean systolic blood pressure (nSBP), nighttime mean diastolic blood pressure, 24‐h systolic blood pressure standard deviation (SBPSD), 24‐h diastolic blood pressure standard deviation, daytime diastolic blood pressure standard deviation, nighttime diastolic blood pressure standard deviation (nDBPSD), nDBPSD (p > .05). However, significant differences were observed between the two groups regarding age, history of coronary heart disease, hypertension, leukoaraiosis, cognitive function, ASP score, SSR, 24‐h SBPSD, daytime systolic blood pressure standard deviation (dSBPSD), nighttime systolic blood pressure standard deviation (nSBPSD), standard deviation of RR interval (SDNN), root mean square value of successive RR interval difference (RMSSD), high‐frequency component (HF), and low‐frequency component (LF) (p < .05). Moreover, the levels of TG, TC, HDL‐C, and LDL‐C did not show significant differences between the two groups (p > .05), but there were significant differences in blood uric acid and homocysteine (Hcy) levels (p < .05). Age, history of leukoaraiosis, cognitive function assessment, blood uric acid, Hcy levels, 24‐h SBPSD, dSBPSD, and nSBPSD showed positive correlations with ASP scores and SSR in patients with cerebral microangiopathy (p < .001). In contrast, hypertension, SDNN, RMSSD, HF, and LF showed negative correlations with ASP scores and SSR (p < .001). Moreover, coronary heart disease was negatively correlated with ASP scores but positively correlated with SSR (p < .001). The independent variables included age, history of leukoaraiosis, cognitive function assessment, ASP score, SSR, blood uric acid, Hcy, bradykinin, coronary heart disease, hypertension, 24‐h SBPSD, dSBPSD, nSBPSD, SDNN, RMSSD, HF, and LF, which were indicators with differences in general data and laboratory indicators. The dependent variable was patients with cerebral microangiopathy combined with autonomic nervous dysfunction. The analysis results showed that age, history of leukoaraiosis, ASP score, SSR, 24‐h SBPSD, dSBPSD, nSBPSD, SDNN, RMSSD, HF, and LF were the influencing factors of patients with cerebral microangiopathy complicated with autonomic nervous dysfunction.ConclusionWe demonstrates that age, history of leukoaraiosis, cognitive function assessment, blood uric acid, Hcy level, 24‐h SBPSD, dSBPSD, nSBPSD, blood pressure, SDNN, RMSSD, HF, LF, and coronary heart disease were highly associated with cerebral microangiopathy with autonomic dysfunction. Furthermore, the influencing factors of cerebral microangiopathy with autonomic dysfunction are age, history of leukoaraiosis, ASP score, SSR, blood pressure variability, and HRV.

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“…Research examining an adequate dose of acupuncture therapy with optimal intervention parameters and time table has also long been neglected and is now urgent (Ma, 2020 ). Recently, a dose-response meta-analysis on major depressive disorder have shown that acupuncture sessions were strongly correlated with its efficacy (Xu et al, 2022 ). On acupuncture for PD, to date, there is no systematic review of the dose-response relationship between acupuncture sessions and its efficacy on PD, but some RCTs have confirmed that the increase of acupuncture sessions may be related to the degree of remission in motor symptoms (Lei et al, 2016 ).…”

Section: Introductionmentioning

confidence: 99%

Qualitative and quantitative meta-analysis of acupuncture effects on the motor function of Parkinson's disease patients

Lei,

Fan,

Liu

et al. 2023

Front. Neurosci.

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ObjectiveTo explore the association between acupuncture sessions and its effects on the motor function of Parkinson's Disease (PD).MethodsEight databases and two clinical trials registries were searched from inception to August 2022. Randomized controlled trials (RCTs) that compared acupuncture with sham acupuncture, or antiparkinsonian drugs, were included. After qualitative meta-analysis, a non-linear meta regression approach with restricted cubic spline was used to investigate the dose-response relationship between acupuncture sessions and their efficacy on the Unified Parkinson's Disease Rating Scale Part III (UPDRS-III) score. Subgroup meta-analysis was performed of the included studies according to the weekly acupuncture frequency. And finally, the included studies containing the determination of intermediate efficacy were compared.ResultsOf the 268 citations screened, 16 studies (462 patients of PD) were included. The qualitative meta-analysis showed that the acupuncture group had better effect on UPDRS-III scores than the control group. And the quantitative meta-analysis suggested that acupuncture dose was correlated with the reduction of UPDRS-III score in PD patients with motor symptoms. In subgroup analysis, on the one hand, when the frequency of acupuncture was no more than 3 times a week, with the increase of acupuncture session, the changes of UPDRS-III score decreased and then increased (P = 0.000). On the other hand, when acupuncture for more than 3 times a week and the dose of acupuncture treatment was <60 times, the changes of UPDRS-III score increased with the increase of acupuncture dose, but the score stopped to decrease if the dose continued to increase (P = 0.020). The comparative analysis of two quantitative RCTs found that the score improvement was more significant at the higher weekly acupuncture frequency.InterpretationThis study found that when treating PD patients with motor symptoms, acupuncture treatment may need to reach a certain dose to obtain better therapeutic effect and excessive acupuncture stimulation may cause the body to develop a certain tolerance. However, the above results still need to be verified by more high-quality clinical studies. The protocol was registered on PROSPERO International Prospective Register of Systematic Reviews (CRD42022351428).

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The dose-effect association between acupuncture sessions and its effects on major depressive disorder: A meta-regression of randomized controlled trials

Cited by 26 publications

References 32 publications

Acupuncture combined with balloon dilation for post-stroke cricopharyngeal achalasia: A meta-analysis of randomized controlled trials

Acupuncture combined with balloon dilation for post-stroke cricopharyngeal achalasia: A meta-analysis of randomized controlled trials

Correlation analysis between cerebral microangiopathy and autonomic nervous dysfunction

Qualitative and quantitative meta-analysis of acupuncture effects on the motor function of Parkinson's disease patients

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