The Dose-Effect Relationship of Chromosome Aberrations to α and γ Irradiation in a Population Subjected to an Increased Burden of Natural Radioactivity

Fischer, Patricia; Pohl-Rüling, J.

doi:10.2307/3575116

Cited by 51 publications

(9 citation statements)

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“…An increase of chromosome breaks was identified in blood lymphocytes of subjects who had a local residency of at least eight-years when compared to a control group of 147 individuals from a region of similar socio-economic status but with normal background levels of radiation. A similar study of individuals from an Austrian population exposed to high levels of background radiation from radon [174] found results in agreement with this previous study, including evidence for a dose-response effect above low exposures, although they did observe a decrease in two-event aberrations in a select group of miners exposed to particularly high levels of radon.…”

Section: Chromosome Aberrationssupporting

confidence: 87%

The Cellular and Molecular Carcinogenic Effects of Radon Exposure: A Review

Robertson

Allen

Laney

et al. 2013

IJMS

124

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Radon-222 is a naturally occurring radioactive gas that is responsible for approximately half of the human annual background radiation exposure globally. Chronic exposure to radon and its decay products is estimated to be the second leading cause of lung cancer behind smoking, and links to other forms of neoplasms have been postulated. Ionizing radiation emitted during the radioactive decay of radon and its progeny can induce a variety of cytogenetic effects that can be biologically damaging and result in an increased risk of carcinogenesis. Suggested effects produced as a result of alpha particle exposure from radon include mutations, chromosome aberrations, generation of reactive oxygen species, modification of the cell cycle, up or down regulation of cytokines and the increased production of proteins associated with cell-cycle regulation and carcinogenesis. A number of potential biomarkers of exposure, including translocations at codon 249 of TP53 in addition to HPRT mutations, have been suggested although, in conclusion, the evidence for such hotspots is insufficient. There is also substantial evidence of bystander effects, which may provide complications when calculating risk estimates as a result of exposure, particularly at low doses where cellular responses often appear to deviate from the linear, no-threshold hypothesis. At low doses, effects may also be dependent on cellular conditions as opposed to dose. The cellular and molecular carcinogenic effects of radon exposure have been observed to be both numerous and complex and the elevated chronic exposure of man may therefore pose a significant public health risk that may extend beyond the association with lung carcinogenesis.

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Section: Chromosome Aberrationssupporting

confidence: 87%

The Cellular and Molecular Carcinogenic Effects of Radon Exposure: A Review

Robertson

Allen

Laney

et al. 2013

IJMS

124

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“…The major effect observed in this study [see also (18)] was that radiation from incorporated isotopes seems to trigger a response that is analogous to the adaptive response to alkylating agents reported by Samson and Schwartz (4). In their experiments, cells chronically exposed to small doses of an alkylating agent were resistant to subsequent exposures to large acute doses of the same chemical.…”

supporting

confidence: 68%

Identification of an Erythrocyte Component Carrying the Duffy Blood Group Fy ^a Antigen

Hadley

David

McGinniss

et al. 1984

Science

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The erythrocyte component carrying the Duffy blood group antigen Fya has been identified as a 35- to 43-kilodalton protein. The protein is degraded by proteases, chymotrypsin, and Pronase, which destroy its antigenicity on intact erythrocytes. Its unusual property of aggregating on being boiled in 5 percent sodium dodecyl sulfate with 5 percent 2-mercaptoethanol distinguishes it from other erythrocyte membrane proteins described to date.

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“…In support of the SET, they cited data on unexpected effects from studies by Luning et al (1963aLuning et al ( , 1963b, Frolen (1970), Nilsson et al (1980) and Pohl-Ruling et al (1979. On the other hand, the other members of the Committee were supportive of the conclusions of the commissioned review.…”

mentioning

confidence: 83%