The double‐edged role of neutrophil heterogeneity in inflammatory diseases and cancers

Abstract

Neutrophils are important immune cells act as the body's first line of defense against infection and respond to diverse inflammatory cues. Many studies have demonstrated that neutrophils display plasticity in inflammatory diseases and cancers. Clarifying the role of neutrophil heterogeneity in inflammatory diseases and cancers will contribute to the development of novel treatment strategies. In this review, we have presented a review on the development of the understanding on neutrophil heterogeneity from the traditional perspective and a high‐resolution viewpoint. A growing body of evidence has confirmed the double‐edged role of neutrophils in inflammatory diseases and tumors. This may be due to a lack of precise understanding of the role of specific neutrophil subsets in the disease. Thus, elucidating specific neutrophil subsets involved in diseases would benefit the development of precision medicine. Thusly, we have summarized the relevance and actions of neutrophil heterogeneity in inflammatory diseases and cancers comprehensively. Meanwhile, we also discussed the potential intervention strategy for neutrophils. This review is intended to deepen our understanding of neutrophil heterogeneity in inflammatory diseases and cancers, while hold promise for precise treatment of neutrophil‐related diseases.

Neutrophil extracellular traps in cancer

“…Moreover, it is postulated that NETs may exert an anticancer effect via direct cytotoxic effects against cancer cells or by inducing an immune response against the tumor. 196 , 197 MPO, an essential component, is capable of destroying melanoma cells. 198 Another crucial component of NETs, histones, have the ability to harm ECs of the blood vessels that supply the tumor.…”