Abstract. Recently, we used the Sinc collocation method with the double exponential transformation to compute eigenvalues for singular Sturm-Liouville problems. In this work, we show that the computation complexity of the eigenvalues of such a differential eigenvalue problem can be considerably reduced when its operator commutes with the parity operator. In this case, the matrices resulting from the Sinc collocation method are centrosymmetric. Utilizing well known properties of centrosymmetric matrices, we transform the problem of solving one large eigensystem into solving two smaller eigensystems. We show that only 1 N+1 of all components need to be computed and stored in order to obtain all eigenvalues, where 2N + 1 corresponds to the dimension of the eigensystem. We applied our result to the Schrödinger equation with the anharmonic potential and the numerical results section clearly illustrates the substantial gain in efficiency and accuracy when using the proposed algorithm.