The Double Reflexogenic Action of Lobeline, Acetylcholine and Cyanides on the Carotid Body, Influence of Phentolamine and Sulpiride

Carvalho, Lopo; Bettencourt, J. Moniz De; Esguelha, N.; Marques, Mário C.; Carvalho, J. S.

doi:10.1007/978-94-015-1155-1_38

Cited by 1 publication

(3 citation statements)

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“…The respiratory rate (RespR) was derived from the tracheal pressure before and after the lobeline administration. The following formula was used: ∆ChR = RespRlobeline-RespRbasal [ 24 ].…”

Section: Methodsmentioning

confidence: 99%

“…In addition to the LPBN, the KF nucleus, which is primarily involved in central respiratory control, also participates in cardiovascular control [ 21 , 22 , 23 , 24 ]. Electrical stimulation of the KF causes a pressor effect with mild tachycardia, and a KF blockade changes the cardiovascular responses produced by glutamate injections into the cuneiform nucleus [ 25 ].…”

Section: Introductionmentioning

confidence: 99%

“…The PAG, another autonomic area, also plays a role in cardiovascular control. Activation of the PAG elicits both respiratory and cardiovascular responses [ 24 , 27 , 28 ]. Dorsal PAG electrical stimulation produces a pressor response in rats with tachycardia, vasodilatation in the hindlimb, and hyperpnea, similar to a defence reaction response [ 29 , 30 ].…”

Section: Introductionmentioning

confidence: 99%

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Central Autonomic Network Regions and Hypertension: Unveiling Sympathetic Activation and Genetic Therapeutic Perspectives

Geraldes,

Laranjo,

Nunes

et al. 2023

Biology

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Introduction: Hypertension, a leading cause of death, was investigated in this study to understand the role of specific brain regions in regulating blood pressure. The lateral parabrachial nucleus (LPBN), Kolliker-fuse nucleus (KF), and periductal grey matter (PAG) were examined for their involvement in hypertension. Methods: Lentiviral vectors were used to alter the activity of these brain regions in hypertensive rats. Over a 75-day period, blood pressure, heart rate, reflex responses, and heart rate variability were measured. Results: Decreasing the activity in the LPBN resulted in a reduced sympathetic outflow, lowering the blood pressure and heart rate. In the KF, the sympathetic activity decreased and chemoreflex variation was attenuated, without affecting the blood pressure. Silencing the PAG had no significant impact on blood pressure or sympathetic tone, but decreased cardiac baroreflex gain. Discussion: These findings highlight the significant role of the LPBN in hypertension-related sympathetic activation. Additionally, LPBN and KF neurons appear to activate mechanisms that control respiration and sympathetic outflow during chemoreceptor activation. Conclusions: The study provided insights into the contribution of the midbrain and pontine regions to neurogenic hypertension and offers potential avenues for future genetic interventions and developing novel treatment approaches.

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“…The respiratory rate (RespR) was derived from the tracheal pressure before and after the lobeline administration. The following formula was used: ∆ChR = RespRlobeline-RespRbasal [ 24 ].…”

Section: Methodsmentioning

confidence: 99%