The Drake Health Registry Study: Cause‐specific mortality experience of workers potentially exposed to beta‐naphthylamine

Cassidy, Laura D.; Youk, Ada O.; Marsh, Gary M.

doi:10.1002/ajim.10268

Cited by 16 publications

(8 citation statements)

References 24 publications

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“…Bladder cancer (49,216,217,218,219) Bladder carcinomas in rats, angiosarcoma, hepatocellular tumors and bladder carcinoma in mice; intestinal tumors, liver sarcoma, mammary tumors, uterus in rats; bronchioalveolar adenoma in mice; uterus carcinomas in rat; bladder carcinomas in rabbits bladder papilloma and bladder carcinoma in dogs (193,220,222,223,224,225,226,227) 2-Naphthylamine Bladder cancer (41,63,156,162,165,169,174,209,228,229,230,231,232,233,234,235,236,237) Liver cholangioma, hepatomas in mice, bladder papilloma in rats, bladder carcinoma and hepatoma in hamster, papilloma and carcinoma of bladder in dog (108, 192, 236. 237, 238, 239, 240, 241,242, 243, 244, 245, 246, 247, 248) o-Toluidine Bladder cancer (160,239,240,249,20,251) Hepatocellular adenoma, carcinomas in mice, fibromas of the skin, spleen mammary fibroadenoma, and sarcoma of rat, fibrosarcoma or osteosarcoma of multiple organs of rat (76,252,253) 4-Chloro-o-Toluidine Bladder cancer (254) Haemangiosma and haemangiosarcoma...…”

Section: -Aminobiphenylmentioning

confidence: 99%

Occurrence uses and carcinogenicity of arylamines

Chung¹

2015

Front Biosci

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Arylamines are chemically synthesized and contained in oxidants, epoxy polymers, explosives, fungicides, pesticides, colorants, polyurethanes, and used in rubber, pharmacology, cosmetics, and other chemical industries. Many arylamines are ubiquitously present in cigarette smoke, cooking fume hoods, foods, automobile exhaust, industrial sites, etc. Some arylamines can be generated through azo reduction by intestinal, skin, and environmental microorganisms from azo dyes that are widely used. Arylamines can also be generated by reduction of the nitro-group containing polyhydrated hydrocarbons including muntions. Some arylamines are released by burning nitrogen containing organic materials at high temperatures. Some medical drugs are also arylamines. Furthermore, many arylamines are essential constituents of normal metabolism or the result of abnormal metabolism or dietary sources. Some arylamines are mutagenic, carcinogenic or the cause of other kinds of maladies. Some arylamine are considered the major etiological agents of bladder tumors in humans and animals but may also induce other types of cancers in various organs. The organ, tissue, and species specificity of the arylamine-inducing carcinogenesis may be determined by their availability, distribution, and the presence of metabolic activation/detoxicification enzymes of each organ or tissue of different species. The ubiquitous arylamines, therefore, pose serious hazards to human health and environment. This article will address the occurrence, uses, carcinogenicity, and other arylamines-induced diseases.

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Section: -Aminobiphenylmentioning

confidence: 99%

Occurrence uses and carcinogenicity of arylamines

Chung¹

2015

Front Biosci

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“…65 Although four studies obtained information on cigarette smoking, two of them calculated smoking-adjusted risk only for bladder cancer, 36 , 38 and one of them had incomplete tobacco smoking data (lacking in about one third of cohort members). 10 Only one study 11 presented an effect estimate for lung cancer risk from a multivariate model; the relative risk for lung cancer incidence after adjustment for age at first exposure, smoking status, and other occupational co-exposure was 3.02 (95% CI, 0.84–10.93) for long duration of employment compared with the short duration group. Lack of adjustment for smoking might lead to overestimation of the association between lung cancer and exposure to BZ/BNA.…”

Section: Discussionmentioning

confidence: 99%

“…8 – 11 However, most studies 8 – 10 failed to confirm a positive dose-response relationship between BZ/BNA exposure and the risk for lung cancer due to an insufficient number of cases. The inadequate statistical evidence of those individual studies would not allow for a proper interpretation of the effect of BZ and/or BNA in regards to lung cancer.…”

Section: Introductionmentioning

confidence: 99%

Risk of Lung Cancer in Workers Exposed to Benzidine and/or Beta-Naphthylamine: A Systematic Review and Meta-Analysis

Tomioka

Saeki

Obayashi

et al. 2016

Journal of Epidemiology

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Benzidine (BZ) and beta-naphthylamine (BNA) have been classified as definite human carcinogens for bladder cancer by the International Agency for Research on Cancer. However, the epidemiological evidence for an association between exposure to BZ and/or BNA and lung cancer has been inconclusive. We conducted a systematic review and meta-analysis to determine the risk for lung cancer among workers exposed to BZ/BNA. A systematic literature search was conducted to identify studies that had reported occupational BZ/BNA exposure and the outcome of interest (lung cancer death and/or incidence). Meta-analyses were performed using random effects models to combine standardized mortality ratios (SMRs) or standardized incidence ratios (SIRs). We identified 23 retrospective cohort studies including 1745 cases of lung cancer; only one study reported smoking-adjusted lung cancer risk. A significantly increased lung cancer risk (pooled SMR/SIR 1.28; 95% CI, 1.14–1.43) was observed by combining all studies, with significant heterogeneity among studies (I2 = 64.1%, P < 0.001). Effect estimates were higher for studies with direct BZ/BNA exposure (ie, dyestuff and manufacturing industries) (pooled SMR/SIR 1.58; 95% CI, 1.31–1.89), and studies that identified BZ/BNA-associated bladder cancer with SMR/SIR ≥4.7 (pooled SMR/SIR 1.68; 95% CI, 1.35–2.09). Effect estimates were similar for studies with and without concomitant occupational exposure to chromium, asbestos, arsenic, or bis(chloromethyl) ether. The cumulative meta-analysis showed that the evidence of association between occupational BZ/BNA exposure and lung cancer has been stable since 1995. Although the results of this meta-analysis have the potential for confounding by smoking and heterogeneity, our findings suggest that a finding of lung cancer following occupational BZ/BNA exposure should be considered to be a potential occupational disease.

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“…Eastern European countries tended to be geographically clustered in this study. Pisani et al (1999), Ginter (2000), Levi et al (1999) and Karimian-Teherani et al (2001) Lei et al, 1996;Zaridze et al, 2000;Jedrychowski et al, 1999;Chow et al, 1999), but also occupational factors (Bulbulyan et al, 1995(Bulbulyan et al, , 1996Gustavsson et al, 1998;Cassidy et al, 2003;Golka et al, 2003) and environmental pollution (Sandor et al, 2001;Gulis et al, 2002;Perera et al, 1992;Shields et al, 1995;Engholm et al, 1996;Choi et al, 1997;Simonato et al, 2000;Franceschi et al, 2003) were found to be possible risk factors for malignant neoplasms. The wide health gap found was due to these unhealthy risk factors (Nanda et al, 1993).…”

Section: Social and Environmentalmentioning

confidence: 99%

The international mortality pattern for 15 sites of malignant neoplasm using factor analysis

Kinoshita

2004

Jpn. J. Health Hum. Ecol

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Many geographical studies relating to malignant neoplasm were carried out in the '70s. The mechanism of gene mutation with respect to malignant neoplasm has been clarified since the '90s. Understanding the geographical distribution of the mortality pattern may be helpful for the exploration of unknown factors concerning the onset of malignant neoplasms, since geographical factors are thought to influence gene mutation. To seek clues for the potential existence of these unknown factors, I examined the relationship between site-specific mortality from malignant neoplasms and geographical distribution for 46 countries. In addition, I tried to understand the characteristics of the Japanese mortality pattern in comparison to other countries. The numbers of deaths categorized by cause, sex and age, and the numbers of populations were obtained from the World Health Organization (WHO) database. Factor analysis was employed for age-adjusted death rates to explore latent factors. Three factors were extracted for each sex. Males' Factor 1, characterized by leukaemia and neoplasms of the lung, colon, bladder, oral cavity, rectum and oesophagus, indicated a pattern similar to females' Factor 2. Eastern European countries may be mainly influenced by males' Factor 1. Females' Factor 1, characterized by neoplasms of the cervix uteri, liver, uterus and stomach, indicated a pattern that is comparatively similar to males' Factor 3. Central and southern American countries and Eastern Europe may be mainly influenced by females' Factor 1. The characteristics of the Japanese mortality pattern could be seen as intermediate between those for Westernized developed areas and less developed areas.

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The Drake Health Registry Study: Cause‐specific mortality experience of workers potentially exposed to beta‐naphthylamine

Cited by 16 publications

References 24 publications

Occurrence uses and carcinogenicity of arylamines

Occurrence uses and carcinogenicity of arylamines

Risk of Lung Cancer in Workers Exposed to Benzidine and/or Beta-Naphthylamine: A Systematic Review and Meta-Analysis

The international mortality pattern for 15 sites of malignant neoplasm using factor analysis

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