The dramatic increase in the rate of methylisothiazolinone contact allergy in <scp>B</scp>elgium: a multicentre study

Aerts, Olivier; Baeck, Marie; Constandt, L.; Dezfoulian, Bita; Jacobs, Marie-Claude; Kerre, Stefan; Lapeere, Hilde; Pierret, L.; Wouters, Kristien; Goossens, An

doi:10.1111/cod.12249

Cited by 110 publications

(159 citation statements)

References 39 publications

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“…Only in a very few cases was the product found to be not in compliance with the legislation. In some cases, the companies have taken voluntary measures to substitute a substance, e.g., such as the preservative MI with a known high sensitisation prevalence [11,12] with substances with a lower sensitising potential.…”

Section: Discussionmentioning

confidence: 99%

Experiences and Statistical Evaluation of Serious Undesirable Effects of Cosmetic Products in the EU

et al. 2016

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The Council of Europe created an outline for a vigilant system of undesirable effects of cosmetic products in 2006. In 2013, some of those aspects were included in the European Cosmetics Regulation (EC) 1223/2009. Since then, serious undesirable effects (SUEs), which are the tip of the iceberg of all undesirable effects of cosmetic products, have to be reported to competent authorities. Neglecting the first phase of establishing the system, we have about two years of experience regarding the notification of SUEs. This notification system is based on a huge amount of cases that allow us to identify occurring problems at an early stage through a signal of increased reported cases for a certain product. It has already been shown that the system is able to identify products that have the potential to cause health risks even if they seem to comply with the legal requirements and the safeguard clause was applied. Until May 2016, 680 cases of SUEs were shared in the EU. The statistics of SUEs indicate that hair dyes and skin care products are the product types that cause the most SUEs. Almost 80% of all SUEs occurred in the head area, especially the skin of the face was affected.

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Section: Discussionmentioning

confidence: 99%

Experiences and Statistical Evaluation of Serious Undesirable Effects of Cosmetic Products in the EU

et al. 2016

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“…This has clearly been exemplified by the introduction of MI into the European cosmetic market in 2005 where MI was given a positive opinion by the SCCS and entered onto Annex V as a preservative allowed for use in cosmetic products. The rapid increase of MI contact allergy has greatly contributed to the overall burden of contact allergy to preservatives, and thousands of European citizens most likely experience allergic contact dermatitis when being in skin contact with cosmetic products preserved with MI or when being exposed to evaporated MI from newly painted rooms [17][18][19].…”

Section: Temporal Trend Of Contact Allergy To Preservativesmentioning

confidence: 99%

“…Several retrospective observational studies from European countries have shown increasing prevalence rates of MI contact allergy from 1.5%-2.5% in 2010 to 6%-12% in 2014 in European contact dermatitis patients [7,17,[35][36][37][41][42][43]. No decline has yet been observed in surveillance data of European patients with contact dermatitis, and the relevance of the MI contact allergy exceeds 70%-80% [7].…”

Section: Contact Allergy To Methylisothiazolinonementioning

confidence: 99%

“…MI contact allergy has been associated with female sex, hand dermatitis, facial dermatitis and work as a painter [7,17,35,36,[41][42][43][44][45][46]. Additionally, it has been shown that MI contact allergy attributes greatly to the increasing prevalence of facial dermatitis observed in patients with preservative contact allergy [7].…”

Section: Contact Allergy To Methylisothiazolinonementioning

confidence: 99%

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Contact Allergy to Preservatives—Is the European Commission a Commendable Risk Manager?

Schwensen

Thyssen

2016

Cosmetics

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Abstract:Although preservatives are necessary to prevent deterioration by microbial growth in cosmetic products, daily skin contact with preserved cosmetic products may cause a preservative contact allergy. Only preservatives with sufficient pre-market risk assessment, presumably being safe for the consumer from a public health point of view, are permitted for use in cosmetic products in the European Union. Notwithstanding the efforts by the European Commission (EC) to avoid epidemics of contact allergy, the former epidemic of contact allergy to methyldibromo glutaronitrile and the unprecedented epidemic of contact allergy to methylisothiazolinone show the procrastination of the European Union risk management process for cosmetic ingredients. Timely risk management is of the utmost importance to avoid rapidly increasing numbers of contact allergy to turn into full-blown epidemics. It is therefore proposed that in order to avoid future epidemics of contact allergy to preservatives, the allowed preservatives in cosmetic products should be entered onto Annex V on a time-limited basis only, and they must be re-evaluated in order to stay on Annex V.

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“…Methylisothiazolinone (MI) is frequently used in personal care products marketed for children, such as wet wipes, moisturizers, and body washes; this increased lately to epidemic proportions due to the massive increase in the use of cosmetic and other exposures [35]. Furthermore, oat and wheat have been described as contact allergens in personal care products, which can lead to protein contact dermatitis [36].…”

Section: Clinical Pictures and Patch Testing In Ad Childrenmentioning

confidence: 99%

Contact Allergy in Atopic Patients: What We Suspected and What We Know

Nardelli

Consigli

Berčík

et al. 2015

Curr Treat Options Allergy

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The dramatic increase in the rate of methylisothiazolinone contact allergy in Belgium: a multicentre study

Cited by 110 publications

References 39 publications

Experiences and Statistical Evaluation of Serious Undesirable Effects of Cosmetic Products in the EU

Experiences and Statistical Evaluation of Serious Undesirable Effects of Cosmetic Products in the EU

Contact Allergy to Preservatives—Is the European Commission a Commendable Risk Manager?

Contact Allergy in Atopic Patients: What We Suspected and What We Know

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