Regional development planning systems contain multiple uncertainties which come from economic restructuring, resource management, carbon peak action, environmental protection, and other factors, it is difficulty to handle all of these uncertainties in one method. In order to solve this problem, a new model developed in this study combines an interval fuzzy program with an environmental quality model for regional development planning in order to provide optimal solutions. The interval fuzzy program is put forward based on interval parameter programming (IPP) and fuzzy programing (FP). The environmental quality model is used to calculate water environmental capacity and atmospheric capacity, which are set as constraint conditions in the model. In order to meet the requirements of carbon peak action, a low carbon development constraint is added to the model. In this model, decision makers can choose the satisfaction level of constraints based on their preferences. The results suggest that the methodology is applicable for the regional development planning system within the planning period. The developed model can be used to generate a series of optimization schema under multiple credibility levels, ensuring that the regional development planning system can meet both societal demands and environmental quality requirements, considering a proper balance between the expected system benefits and risks of violating the resource constraint and low carbon development constraint.