The Drosophila learning and memory gene <i>linotte</i> encodes a putative receptor tyrosine kinase homologous to the human RYK gene product

Dura, Jean-Maurice; Taillebourg, Emmanuel; Préat, Thomas

doi:10.1016/0014-5793(95)00847-3

Cited by 62 publications

(43 citation statements)

References 42 publications

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“…Ryk is important for establishing planar polarity during neural tube formation [13][14][15], differentiation of mouse cortical and dopaminergic midbrain progenitors [16,17], and specification and migration of GABAergic interneurons during cortical development [18,19]. Derailed is also required for mushroom body development, glomerular patterning, neuromuscular junction formation, synaptogenesis and memory and learning in the fly [20][21][22][23]. These other facets of Ryk function have been comprehensively covered in several recent reviews [24][25][26].…”

Section: Ryk a Novel Wnt Receptormentioning

confidence: 99%

The Yin and Yang of Wnt/Ryk axon guidance in development and regeneration

Clark

Liu

Cooper

2014

Sci. China Life Sci.

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In the developing embryo, nascent axons navigate towards their specific targets to establish the intricate network of axonal connections linking neurons within the mature nervous system. Molecular navigational systems comprising repulsive and attractive guidance cues form chemotactic gradients along the pathway of the exploring growth cone. Axon-bound receptors detect these gradients and determine the trajectory of the migrating growth cone. In contrast to their benevolent role in the developing nervous system, repulsive guidance receptors are detrimental to the axon's ability to regenerate after injury in the adult. In this review we explore the essential and beneficial role played by the chemorepulsive Wnt receptor, Ryk/Derailed in axon navigation in the embryonic nervous system (the Yin function). Specifically, we focus on the role of Wnt5a/Rykmediated guidance in the establishment of two major axon tracts in the mammalian central nervous system, the corticospinal tract and the corpus callosum. Recent studies have also identified Ryk as a major suppressor of axonal regeneration after spinal cord injury. Thus, we also discuss this opposing aspect of Ryk function in axonal regeneration where its activity is a major impediment to axon regrowth (the Yang function).Ryk, Derailed, Wnt, Wnt signalling, axon guidance, axonal regeneration, spinal cord injury Citation:Clark CEJ, Liu YB, Cooper HM. The Yin and Yang of Wnt/Ryk axon guidance in development and regeneration.

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Section: Ryk a Novel Wnt Receptormentioning

confidence: 99%

The Yin and Yang of Wnt/Ryk axon guidance in development and regeneration

Clark

Liu

Cooper

2014

Sci. China Life Sci.

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“…The fact that Drk is a SH2/SH3 adaptor protein that directly binds to activated receptor tyrosine kinase (RTK) strongly implicates the involvement of a yet-unknown RTK in modulation of OA neuronal activity. At least 14 RTK genes have been identified in the Drosophila genome (28)(29)(30)(31)(32)(33)(34). To identify which RTK(s) are involved, we performed dsRNA-mediated knockdown of the 14 known RTK genes in tdc2-Gal4 neurons (Table S2).…”

Section: Mb04794mentioning

confidence: 99%

Octopamine-mediated circuit mechanism underlying controlled appetite for palatable food in Drosophila

Zhang

Branch

Shen

2013

Proc. Natl. Acad. Sci. U.S.A.

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The easy accessibility of energy-rich palatable food makes it difficult to resist food temptation. Drosophila larvae are surrounded by sugar-rich food most of their lives, raising the question of how these animals modulate food-seeking behaviors in tune with physiological needs. Here we describe a circuit mechanism defined by neurons expressing tdc2-Gal4 (a tyrosine decarboxylase 2 promoter-directed driver) that selectively drives a distinct foraging strategy in food-deprived larvae. Stimulation of this otherwise functionally latent circuit in tdc2-Gal4 neurons was sufficient to induce exuberant feeding of liquid food in fed animals, whereas targeted lesions in a small subset of tdc2-Gal4 neurons in the subesophageal ganglion blocked hunger-driven increases in the feeding response. Furthermore, regulation of feeding rate enhancement by tdc2-Gal4 neurons requires a novel signaling mechanism involving the VEGF2-like receptor, octopamine, and its receptor. Our findings provide fresh insight for the neurobiology and evolution of appetitive motivation. T he adaptive control of foraging decisions is crucial to survival and reproduction and is mediated by complex brain mechanisms. For example, in hungry animals, feeding behaviors can be modulated by diverse neural systems including those responsible for receiving and processing sensory properties and assigning reward and motivational significance of food stimuli (1-3). At present, elucidation of molecular and circuit mechanisms underlying the adaptive control of feeding behavior remains highly challenging.Our previous studies have shown that Drosophila larvae, like mammals, display diverse adaptive foraging strategies in response to appetizing odors or satiety state and food quality (4-6). For example, larvae fed for ad libitum intake tend to prefer soft, liquid sugar media that contain readily ingestible sugar solution but decline solid media in which sugar solution is embedded in gelled agar and is less accessible (5). However, as food deprivation is prolonged, larvae will become increasingly persistent in extracting the sugar solution from solid media (7). We have also shown that an evolutionarily conserved signaling cascade, involving neuropeptide F (NPF, the fly homolog of neuropeptide Y, or NPY) and insulin-like peptides (dILPs), selectively integrates motivational state (hunger) with persistence to pulverize solid food (5, 7).The observation that the conserved NPY-like system selectively promotes food acquisition behaviors that require high energetic cost has led us to postulate that fly larvae may use other conserved neural mechanisms to regulate acquisition of readily accessible palatable food. In this work, we provide evidence which supports this hypothesis. We show that an octopamine (OA)/β-adrenergic-like receptor (Octß3R)-dependent circuit mechanism selectively regulates appetite for soft sugar media. This circuit mechanism seems to involve two subsets of tdc2-Gal4 neurons in the subesophogeal ganglia (SOG). One of them mediates the hunger-driven increase ...

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“…The drl (lio) mutants were lio 2 (Dura et al, 1995;Moreau-Fauvarque et al, 2002), drl R343 and drl Red2 (Callahan et al, 1996;. The Wnt5 null allele used was Wnt5 400 (Fradkin et al, 2004).…”

Section: Drosophila Stocksmentioning

confidence: 99%

“…The DRL protein was subsequently shown to be a receptor tyrosine kinase (RTK) (Dura et al, 1995;Callahan et al, 1995) belonging to the RYK subfamily of RTKs (Halford et al, 1999;Hovens et al, 1992). drl mutants present structural brain defects in the MBs (Moreau-Fauvarque et al, 1998;MoreauFauvarque et al, 2002;Simon et al, 1998).…”

Section: Introductionmentioning

confidence: 99%

Respective roles of the DRL receptor and its ligand WNT5 inDrosophilamushroom body development

et al. 2007

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In recent decades, Drosophila mushroom bodies (MBs) have become a powerful model for elucidating the molecular mechanisms underlying brain development and function. We have previously characterized the derailed (drl; also known as linotte) receptor tyrosine kinase as an essential component of adult MB development. Here we show, using MARCM clones, a non-cell-autonomous requirement for the DRL receptor in MB development. This result is in accordance with the pattern of DRL expression, which occurs throughout development close to, but not inside, MB cells. While DRL expression can be detected within both interhemispheric glial and commissural neuronal cells, rescue of the drl MB defects appears to involve the latter cellular type. The WNT5 protein has been shown to act as a repulsive ligand for the DRL receptor in the embryonic central nervous system. We show here that WNT5 is required intrinsically within MB neurons for proper MB axonal growth and probably interacts with the extrinsic DRL receptor in order to stop axonal growth. We therefore propose that the neuronal requirement for both proteins defines an interacting network acting during MB development.

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The Drosophila learning and memory gene linotte encodes a putative receptor tyrosine kinase homologous to the human RYK gene product

Cited by 62 publications

References 42 publications

The Yin and Yang of Wnt/Ryk axon guidance in development and regeneration

The Yin and Yang of Wnt/Ryk axon guidance in development and regeneration

Octopamine-mediated circuit mechanism underlying controlled appetite for palatable food in Drosophila

Respective roles of the DRL receptor and its ligand WNT5 inDrosophilamushroom body development

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