The drugs that mostly frequently induce acute kidney injury: a case − noncase study of a pharmacovigilance database

Pierson-Marchandise, Marion; Gras, Valérie; Moragny, Julien; Micallef, Joëlle; Gaboriau, Louise; Picard, Sylvie; Choukroun, Gabriel; Masmoudi, Kamel; Liabeuf, Sophie

doi:10.1111/bcp.13216

Cited by 87 publications

(73 citation statements)

References 40 publications

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“…The lists of medications and medication combinations have been reviewed by a nephrologist to validate the results. Most of these medications are already known to be nephrotoxic in the existing literature, which confirms the accuracy of our findings through VISA_M3R3 [87][88][89][90][91][92].…”

Section: Discussionsupporting

confidence: 90%

Multiple Regression Analysis and Frequent Itemset Mining of Electronic Medical Records: A Visual Analytics Approach Using VISA_M3R3

Abdullah

Rostamzadeh

Sedig

et al. 2020

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Medication-induced acute kidney injury (AKI) is a well-known problem in clinical medicine. This paper reports the first development of a visual analytics (VA) system that examines how different medications associate with AKI. In this paper, we introduce and describe VISA_M3R3, a VA system designed to assist healthcare researchers in identifying medications and medication combinations that associate with a higher risk of AKI using electronic medical records (EMRs). By integrating multiple regression models, frequent itemset mining, data visualization, and human-data interaction mechanisms, VISA_M3R3 allows users to explore complex relationships between medications and AKI in such a way that would be difficult or sometimes even impossible without the help of a VA system. Through an analysis of 595 medications using VISA_M3R3, we have identified 55 AKI-inducing medications, 24,212 frequent medication groups, and 78 medication groups that are associated with AKI. The purpose of this paper is to demonstrate the usefulness of VISA_M3R3 in the investigation of medication-induced AKI in particular and other clinical problems in general. Furthermore, this research highlights what needs to be considered in the future when designing VA systems that are intended to support gaining novel and deep insights into massive existing EMRs.

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Section: Discussionsupporting

confidence: 90%

Multiple Regression Analysis and Frequent Itemset Mining of Electronic Medical Records: A Visual Analytics Approach Using VISA_M3R3

Abdullah

Rostamzadeh

Sedig

et al. 2020

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“…Cisplatin-induced severe tubular necrosis with significant deterioration of kidney function as demonstrated by elevated urea and creatinine in group treated with cisplatin compared to control group. It was reported that cisplatin is one of the drugs that induced AKI with higher odds ratio >10 [ 31 ]. Many reports of animal models demonstrated same kidney structural damage [ 32 , 33 ].…”

Section: Discussionmentioning

confidence: 99%

Effect of combination sildenafil and gemfibrozil on cisplatin-induced nephrotoxicity; role of heme oxygenase-1

et al. 2018

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Background/aim: Cisplatin-induced nephrotoxicity in large proportion of patients. The aim of this work is to clarify the effect of combination of sildenafil and gemfibrozil on cisplatin-induced nephrotoxicity either before or after cisplatin treatment and determination of nephrotoxicity predictors among the measured tissue markers.Methods: Thirty two adult male albino rats were divided into four equal groups (G) GI control, GII received cisplatin, GIII received sildenafil and gemfibrozil before cisplatin, GIV received sildenafil and gemfibrozil after cisplatin. Creatinine and urea were measured and animals were sacrificed and kidney was taken for histopathology. The following tissue markers were measured, heme oxygenase-1 (HO-1) activity, reduced glutathione, quantitative (real-time polymerase chain reaction) RT-PCR for gene expression of tumor necrosis factor alpha (TNF-α) and endothelial nitric oxide synthase (ENOS) level.Results: GII developed AKI demonstrated by significantly high urea and creatinine and severe diffuse (80–90%) tubular necrosis. TNF-α was highly and significantly elevated while the rest of tissue markers were significantly reduced in GI1 compared to other groups. GIV showed better results compared to GIII. There was a significant positive correlation between creatinine and TNF-α when combining GI and GII while there were significant negative correlation between creatinine and other tissue markers in same groups. Linear regression analysis demonstrated that HO-1 was the independent predictor of AKI demonstrated by elevated creatinine among GI and GII.Conclusions: Combination of sildenafil and gemfibrozil can be used in treatment of cisplatin-induced nephrotoxicity. HO-1 is a promising target for prevention and/or treatment of cisplatin-induced nephrotoxicity.

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“…It is known that the most important mechanism of gentamicin nephrotoxicity is the hyperproduction of reactive oxygen species, causing damage to proteins, DNA and peroxidation of lipids, with an alteration of the integrity of cellular membranes and development of morphofunctional disorders [1,17]. This fact conditions numerous research on the effectiveness of prevention of the gentamicin nephropathy, using known and new antioxidants [1,2,4,[8][9][10][11][12]20].…”

Section: Discussionmentioning

confidence: 99%

“…Aminoglycoside antibiotic gentamicin is widely used for the treatment and prophylaxis of Gram negative bacterial infections, though development of nephrotoxicity in 20-30% of patients significantly limits its use [2,17,20,23].…”

Section: Introductionmentioning

confidence: 99%

Morphofunctional Changes in Kidneys of Rats With Gentamicin-Induced Acute Kidney Injury and Use of Melatonin

et al. 2018

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Aminoglycosides are effective antibiotics, but their accumulation in kidney cortex causes nephrotoxic effects in 20-30% of patients, which significantly limits their use. For this reason, search for the new therapies aimed at prevention of gentamicin-induced acute kidney injury (AKI) is highly relevant. Thus, the objective of our research was to study the functional and histopathological changes in kidneys of rats with gentamicin-induced AKI, and estimate the renoprotective potential of pineal hormone melatonin, which possesses antioxidant, anti-inflammatory and immunomodulatory effects. The study was conducted on 24 non-linear male rats. Gentamicin-induced AKI was modeled by daily administration of 4% gentamicin sulphate (80 mg/kg) for 6 days. Melatonin (Sigma Aldrich, USA) was injected daily at a dose of 5 mg/kg. Functional state of kidneys was assessed by diuresis, creatinine clearance, urine protein excretion, fractional excretion of sodium, and plasma potassium level. Documentation of the pathological processes was performed by the computer morphometry of objects in histological preparations. Statistical analysis of the data was performed using SPSS 17.0 software. Administration of gentamicin resulted in a significant impairment of renal function of experimental animals. A decrease in creatinine clearance by 3.1 times along with a reduction of diuresis by 1.9 times, and an increase in plasma creatinine concentration by 2.6 times was observed. There also was an increase in urine protein level by 5.2 times, an elevation of fractional sodium excretion and a reduction of plasma potassium level. Use of melatonin caused a significant improvement of renal function comparing to model pathology group. Functional disturbances were accompanied with the significant histopathological changes in kidney tissue: necrosis of the 27±5.2% epithelial cells of proximal tubules with the signs of hydropic vacuolization (7±2.1%) or reversible hydropic swelling (76±1.5%) in the rest of cells; swelling or deformation of some glomeruli. In the medulla tubular lumen were dilated and partially filled with hyaline casts, tubular cells had signs of dystrophy. Use of melatonin contributed to the restraint of the histopathological changes, confirmed by the decrease of the prevalence and severity of tubular necrosis (1.2%), dystrophy (64±2.3%), and injury of glomeruli. Obtained results verify the significant nephroprotective effect of pineal hormone melatonin, providing a background for the further in-depth study of its renal effects as well as its prospects as a nephroprotector.

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The drugs that mostly frequently induce acute kidney injury: a case − noncase study of a pharmacovigilance database

Cited by 87 publications

References 40 publications

Multiple Regression Analysis and Frequent Itemset Mining of Electronic Medical Records: A Visual Analytics Approach Using VISA_M3R3

Multiple Regression Analysis and Frequent Itemset Mining of Electronic Medical Records: A Visual Analytics Approach Using VISA_M3R3

Effect of combination sildenafil and gemfibrozil on cisplatin-induced nephrotoxicity; role of heme oxygenase-1

Morphofunctional Changes in Kidneys of Rats With Gentamicin-Induced Acute Kidney Injury and Use of Melatonin

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