The drying rates of spray freeze drying systems increase through the use of stratified packed bed structures

Bruttini, Roberto; Liapis, Athanasios I.

doi:10.1016/j.ijheatmasstransfer.2015.06.081

Cited by 21 publications

(8 citation statements)

References 19 publications

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“…Various examples of stratified packings have already been shown to have beneficial properties. 9,[11][12][13][14]17,18,23,42,43 Model-based methods are ideally suited to make optimal use of those benefits.…”

Section: Discussionmentioning

confidence: 99%

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Model‐based design of stratified packings for enhanced mass transfer using optimal control theory

Eppink,

Kuhn,

Briesen

2023

AIChE Journal

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Various examples show that stratified columns can improve the transport performance of particle packings. However, to date, there is no universal strategy to design these packings to yield optimal performance. This study proposes a model‐based approach for designing particle packings in which mass transfer occurs between a liquid phase and a stationary phase using optimal control theory. The primary objective is to provide a general design strategy that is applicable across different unit operations in chemical, pharmaceutical, and food applications. Optimal control is utilized to determine the optimal particle diameter as a function of the axial position within the column. We demonstrate the approach using two case studies and three different optimization criteria. Numerical results indicate that the proposed method is highly effective, for example, the solvent demand is reduced by up to . Moreover, the optimally graded packing yields a significantly sharper breakthrough curve of an adsorption column.

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Section: Discussionmentioning

confidence: 99%

“…We are convinced that methods like those presented in this contribution will become increasingly important. Various examples of stratified packings have already been shown to have beneficial properties 9,11–14,17,18,23,42,43 . Model‐based methods are ideally suited to make optimal use of those benefits.…”

Section: Discussionmentioning

confidence: 99%

Model‐based design of stratified packings for enhanced mass transfer using optimal control theory

Eppink,

Kuhn,

Briesen

2023

AIChE Journal

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“…This SFD technology has been used to produce high activity probiotics, coffee powder with volatile compounds, high-quality milk powder, and other powdered foods. Future research tends to focus on the development and simulation of new spray freeze-drying devices [35,47], the optimization of process parameters, the online measurement of temperature and humidity distribution, and the control of multi-level continuous drying in order to realize its compact, automatic, and energy-saving properties [48]. In recent years, new spray freeze-drying devices and methods have also been reported.…”

Section: Integrated Spray Freeze Coating Equipment and Its Engineerin...mentioning

confidence: 99%

Spray Freezing Coating on the Carrier Particles for Powder Preparation

Wang

Zhang

et al. 2022

Coatings

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Carrier particle spray freeze-drying is a new technology with high added value for thermosensitive powder spray freeze-drying. The technology includes the following steps: atomization, coating, freezing, and drying. Due to the action of carrier particles, the condensation of frozen droplets in the conventional spray freeze-drying process is overcome. However, there are many influencing factors involved in the process of freezing coating. The mechanism of the complex droplet collision freezing process still needs to be studied. In this paper, from the perspective of spray freezing coating after atomized droplets collide with low-temperature carrier particles, the coating process and freezing process of single droplets impacting the sphere are analyzed microscopically. The freezing coating processes of static and dynamic carrier particles are reviewed. Moreover, the surface evaluation of powder and equipment development for creating powder products is discussed.

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“…Bruttini and Liapis [89] suggested that the use of a layered packed bed structure where the smallest particles are at the bottom in contact with heating plate while the largest particles are placed on the upper part of the bed in the SFD process may result in higher average total heat and mass transfer rates than those obtained by using a single packed bed with the same particle size and, thus, may speed up both primary and secondary drying. In another study, the impact of using inert particles on drying time was investigated by Zhang et al [18] to reduce the poor heat transfer through the large particle-to-particle voids within a packed bed.…”

Section: Vacuum Freeze-dryingmentioning

confidence: 99%

Spray Freeze-Drying as a Solution to Continuous Manufacturing of Pharmaceutical Products in Bulk

et al. 2020

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Pharmaceutical manufacturing is evolving from traditional batch processes to continuous ones. The new global competition focused on throughput and quality of drug products is certainly the driving force behind this transition which, thus, represents the new challenge of pharmaceutical manufacturing and hence of lyophilization as a downstream operation. In this direction, the present review deals with the most recent technologies, based on spray freeze-drying, that can achieve this objective. It provides a comprehensive overview of the physics behind this process and of the most recent equipment design.

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The drying rates of spray freeze drying systems increase through the use of stratified packed bed structures

Cited by 21 publications

References 19 publications

Model‐based design of stratified packings for enhanced mass transfer using optimal control theory

Model‐based design of stratified packings for enhanced mass transfer using optimal control theory

Spray Freezing Coating on the Carrier Particles for Powder Preparation

Spray Freeze-Drying as a Solution to Continuous Manufacturing of Pharmaceutical Products in Bulk

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