The dual behavior of heat shock protein 70 and asymmetric dimethylarginine in relation to serum CRP levels in type 2 diabetes

Shalchi

et al. 2016

Self Cite

We aimed to study the relation between plasma levels of stress-induced heat shock protein 70 (HSPA1A) with plasminogen activator inhibitor-1 (PAI-1) and highdensity lipoprotein cholesterol (HDL-C), apolipoprotein A1 (Apo-A1), and HDL-C/Apo-A1 ratio. In a matched case-control study on patients with diabetes (40 patients with albuminuria and 40 without albuminuria matched for age, sex, and body mass index), we observed that plasma levels of HSPA1A and PAI-1 are increased in patients with albuminuria (0.55±0.02 vs. 0.77±0.04 ng/ml, p value <0.001 for HSPA1A; 25.9±2 vs. 31.8±2.4 ng/ml, p value <0.05 for PAI-1). There was a significant correlation between HSPA1A and PAI-1 in diabetic patients without albuminuria (r=0.28; p value=0.04), but not in those with albuminuria (r=0.07; p value=0.63). No association was found between HSPA1A and HDL-C, between HSPA1A and Apo-A1, or between HSPA1A and HDL-C/Apo-A1 ratio. We concluded that there is a direct correlation between plasma HSPA1A and PAI-1 levels in patients with diabetes, which is lost when they develop albuminuria.

Section: Discussionsupporting

confidence: 52%

The lost correlation between heat shock protein 70 (HSPA1A) and plasminogen activator inhibitor-1 in patients with type 2 diabetes and albuminuria

Shalchi

et al. 2016

Self Cite

“…In other disease such as pulmonary fibrosis, there is an increased HSP47 induction, which is associated with collagen deposition (Iwashita et al 2000). We have previously shown the duality of HSP70 behavior in low and high inflammatory states (Nakhjavani et al 2012). These observations have questioned the classic role of these molecules as chaperons.…”

Section: Discussionmentioning

confidence: 98%

Heat shock protein 70 and albuminuria in patients with type 2 diabetes: a matched case control study

Morteza

Nakhjavani

Larry

et al. 2013

Self Cite

Here, we aimed to study serum heat shock protein (HSP) 70 levels in diabetic patients with and without albuminuria. We performed a 1:1 matched case control study on 40 diabetic patients with albuminuria as cases and 40 age, sex, body mass index matched diabetic patients without albuminuria (normoalbuminuria) as controls. Normoalbuminuria was defined as urinary albumin excretion rate <15 mg/12 h, and albuminuria was defined as urinary albumin excretion rate between 100-400 mg/12 h. Patients with albuminuria had a higher HSP70 than controls (0.83±0.50 vs. 0.63±0.06; p= 0.02), while they did not differ in any other studied variables. In ten of the studied pairs, the controls had higher HSP70 levels than cases (reverse relationship). Patients in the "direct relationship group" had higher HbA1c values than the patients in the "reverse relationship group" (8.9±0.3 vs. 7.3±0.6, p=0.04). Cases in the reverse pairs had a lower low density lipoprotein cholesterol levels than their controls. The odds ratio of HSP70 in the prediction of albuminuria was (28.69 (3.2-250.1), p=0.002). In conclusion, we have shown an increased HSP70 levels in diabetic patients with albuminuria.

“…A growing number of studies demonstrate that circulating Hsp70 levels are elevated in type 1 and 2 diabetes mellitus (Morteza et al 2013;Nakhjavani et al 2010Nakhjavani et al , 2011Nakhjavani et al , 2012Oglesbee et al 2005). Inflammation and oxidative stress, characteristic features of diabetes mellitus, have been suggested to account for the increase in serum Hsp70 concentrations in these disorders.…”

Section: Discussionmentioning

confidence: 99%

Increased circulating heat shock protein 70 (HSPA1A) levels in gestational diabetes mellitus: a pilot study

Griger

Prohászka

Rigó

et al. 2015

Recent data indicate that serum Hsp70 (HSPA1A) levels are increased in type 1 and 2 diabetes mellitus. However, there is no report in the literature on circulating Hsp70 levels in gestational diabetes mellitus. In this pilot study, we measured serum Hsp70 levels in 11 pregnant women with pregestational diabetes, 38 women with gestational diabetes, and 40 healthy pregnant women with ELISA. Plasma glucose levels, serum insulin concentrations, HbA1c values, and the Homeostatic Model Assessment-Insulin Resistance (HOMA-IR) index were also determined. According to our results, serum Hsp70 concentrations were significantly higher in women with pregestational and gestational diabetes mellitus than in healthy pregnant women. In addition, pregestational diabetic women had significantly higher Hsp70 levels than those with gestational diabetes. Furthermore, in the group of women with gestational diabetes mellitus, serum Hsp70 levels showed a significant positive correlation with HbA1c values. However, there was no other relationship between clinical features and metabolic parameters of the study subjects and their serum Hsp70 levels in either study group. In conclusion, we demonstrated for the first time in the literature that serum Hsp70 levels are increased and correlate with HbA1c values in women with gestational diabetes mellitus. Nevertheless, further studies are needed to determine whether circulating Hsp70 plays a causative role in the pathogenesis of gestational diabetes or elevated serum Hsp70 levels are only consequences of the disease.