The dual nature of the reaction between porcine elastase and human plasma α1 proteinase inhibitor

Satoh, Shinobu; Kurecki, T; Kress, Lawrence F.; Laskowski, M.

doi:10.1016/0006-291x(79)90391-7

Cited by 41 publications

(16 citation statements)

References 19 publications

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confidence: 99%

“…One such example is a-l-proteinase inhibitor (a-i-PI), the major serum proteinase inhibitor (4)(5)(6)(7)(8). This protein has been postulated to play a critical role in modulating the activity of the neutral proteinase, elastase, in lung (4)(5)(6)(7)(8)(9)(10)(11). Inactivation ofa-I-PI has been implicated in the excessive destruction of lung tissue seen in emphysema, and there is evidence that limited exposure of a-I-PI to oxidizing agents results in oxidation of methionine residues to Met(O) and inactivation ofthe protein's function (4)(5)(6)(7)(8)(9)(10)(11)(12).…”

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confidence: 99%

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Enzymatic reduction of oxidized alpha-1-proteinase inhibitor restores biological activity.

Abrams¹,

Weinbaum²,

Weissbach³

et al. 1981

Proc. Natl. Acad. Sci. U.S.A.

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confidence: 99%

mentioning

confidence: 99%

Enzymatic reduction of oxidized alpha-1-proteinase inhibitor restores biological activity.

Abrams¹,

Weinbaum²,

Weissbach³

et al. 1981

Proc. Natl. Acad. Sci. U.S.A.

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“…The in vivo effects on the EIC of serum are similar to that seen when CT is added to isolated a-i-PI or serum in vitro ( 11,12,14). That is, there is a preferential decrease in the EIC compared with the TIC.…”

Section: Discussionmentioning

confidence: 52%

“…a-i-PI measured immunologically during the course of treatment was unchanged, which indicates that the protein was inactivated, but that the inactive a-l-PI was cleared in a normal fashion. The EIC did not return to normal concentrations until 14 d after the termination of treatment. This observation is comparable with previous observations, which suggested that a-l-PI has a turnover rate in man and monkey of about 4 d (12,(36)(37)(38)(39).…”

Section: Discussionmentioning

confidence: 90%

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A model of decreased functional alpha-1-proteinase inhibitor. Pulmonary pathology of dogs exposed to chloramine T.

Abrams¹,

Cohen²,

Damiano³

et al. 1981

J. Clin. Invest.

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A B S T R A C T The objective of this study was to develop an animal model representative of chronic human a-1-proteinase inhibitor deficiency. Eight dogs were treated with a mild oxidizing agent, chloramine T, with varying regimens for 3-27 wk. The capacity of the serum to inhibit both trypsin and elastase was examined and found to respond differently. Although immunologically determined levels of protease inhibitor did not change, the ability of serum to inhibit elastase in an in vitro assay decreased in direct response to chloramine T treatment. The trypsin inhibitory capacity was less affected. Emphysemalike alterations in lung morphology were observable when histologic sections were evaluated both subjectively and objectively by mean linear intercept measurements. The data suggest that this model parallels the emphysema associated with the genetic a-l-proteinase inhibitor deficiency in man.

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REVIEW: Methionine Sulfoxide and the Oxidative Regulation of Plasma Proteinase Inhibitors

Swaim

Pizzo

1988

Journal of Leukocyte Biology

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The sensitivity of methionine residues to oxidation is a mechanism by which many proteins, including plasma proteinase inhibitors, may be oxidatively inactivated. Much evidence suggests that methionine oxidation and concurrent losses of protein activity not only occur widely in living systems but are physiologic, homeostatic processes. Neutrophils, macrophages and other leukocytes secrete large quantities of powerful oxidants at sites of inflammation and may readily bring about methionine oxidative inactivation of proteins. In particular, oxidation of proteinase inhibitors may favorably alter the proteinase-antiproteinase balance to facilitate tissue remodeling and protection from invading organisms. Leukocyte-mediated inhibitor oxidation also appears to regulate local immunosuppressive activity. Pathophysiologic processes such as emphysema and rheumatoidal disease involve derangements of these homeostatic mechanisms.

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The dual nature of the reaction between porcine elastase and human plasma α1 proteinase inhibitor

Cited by 41 publications

References 19 publications

Enzymatic reduction of oxidized alpha-1-proteinase inhibitor restores biological activity.

Enzymatic reduction of oxidized alpha-1-proteinase inhibitor restores biological activity.

A model of decreased functional alpha-1-proteinase inhibitor. Pulmonary pathology of dogs exposed to chloramine T.

REVIEW: Methionine Sulfoxide and the Oxidative Regulation of Plasma Proteinase Inhibitors

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