The dual therapeutic effect of metformin nuclei‐based drugs modified with one of Tulbaghia violacea extract compounds

Hassan, Safaa S.; Bedir, Elaria A; Hamza, Abd El-Rahman M; Ahmed, Ahmed M.; Ibrahim, Nouran Mahmoud; El‐Ghany, Mahmoud S. Abd; Khattab, Nada N.; Emeira, Bassant M.; Salama, Mabrook M.; Mohamed, Eman F.; Fayed, Dalia B.

doi:10.1002/aoc.6804

Cited by 11 publications

(2 citation statements)

References 61 publications

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“…28 4-(dimethylamino) benzaldehyde is one of the aromatic aldehydes that were shown to have biological activity. 29,30 This makes Schiff bases derived from aromatic aldehydes such as: 4-N,N-dimethylaminobenzaldehyde have a wide variety of applications and characteristics including antibacterial activity against several human pathogenic bacteria. 31 The synthetic Schiff bases were modified by their coordination with metal ions that were found to have an improved antibacterial activity and credibility than the parent Schiff bases.…”

Section: Introductionmentioning

confidence: 99%

“…Aromatic aldehydes have an effective conjugation system, and therefore are more stable than aliphatic ones 28 . 4‐(dimethylamino)benzaldehyde is one of the aromatic aldehydes that were shown to have biological activity 29,30 . This makes Schiff bases derived from aromatic aldehydes such as: 4‐ N , N ‐dimethylaminobenzaldehyde have a wide variety of applications and characteristics including antibacterial activity against several human pathogenic bacteria 31 .…”

Section: Introductionmentioning

confidence: 99%

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Antimicrobial screening involving Helicobacter pylori of nano‐therapeutic compounds based on the amoxicillin antibiotic drug

Hassan,

Nader,

Nagy

et al. 2023

Helicobacter

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Nano‐structure Cu(II) complex [Cu(AMAB)2]Cl2 with Schiff base (AMAB) derived from the condensation between 4‐(dimethylamino)benzaldehyde and amoxicillin trihydrate was prepared. (AMAB) Schiff base and its Cu(II) complex were identified and confirmed by different physicochemical techniques. The Schiff base (AMAB) was coordinated to copper ion through carbonyl oxygen and imine nitrogen donor sites. X‐ray powder diffraction shows a cubic crystal system of the Cu(II) complex. The density functional theory was used to optimize the structure geometries of the investigated compounds. The molecular docking of the active amino acids of the investigated proteins' interactions with the tested compounds was evaluated. The bactericidal or bacteriostatic effect of the compounds was screened against some bacterial strains. The activity of Cu‐chelate against Gram‐negative bacteria was mainly more effective than its (AMAB) ligand and vice versa in the case of Gram‐positive bacteria. The biological activity of the prepared compounds with biomolecules calf thymus DNA (CT‐DNA) was determined by electronic absorption spectra and DNA gel electrophoresis technique. All studies revealed that the Cu‐chelate derivative exhibited better binding affinity to both CT‐DNA than the AMAB and amoxicillin itself. The anti‐inflammatory effect of the designed compounds was determined by testing their protein denaturation inhibitory activity spectrophotometrically. All obtained data supported that the designed nano‐Cu(II) complex with Schiff base (AMAB) is a potent bactericide against H. pylori, and exhibits anti‐inflammatory activity. The dual inhibition effects of the designed compound represent a modern therapeutic approach with extended spectrum of action. Therefore, it can act as good drug target in antimicrobial and anti‐inflammtory therapies. Finally, H. pylori resistance to amoxicillin is absent or rare in many countries, thus amoxicillin nanoparticles may be beneficial for countries where amoxicillin resistance is reported.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Antimicrobial screening involving Helicobacter pylori of nano‐therapeutic compounds based on the amoxicillin antibiotic drug

Hassan,

Nader,

Nagy

et al. 2023

Helicobacter

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The double‐edged sword of the amoxicillin antibiotic against prostate cancer in nano palladium form and its electrochemical detection of dopamine

Hassan

Hanna

Medany

2023

Applied Organom Chemis

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Pd (II) complex was prepared from the interaction with Schiff base based on the condensation amoxicillin trihydrate drug and 4-N,N-dimethylaminobenzaldehyde. The complex was prepared on the nanoscale that was investigated using transmission electron microscopy (TEM). The chemical structure of the synthesized Schiff base and its Pd (II) chelate was proved through several techniques. Assays using MTT and lactate dehydrogenase verified the Pd (II) complex ability to inhibit human prostate cancer cells (PC3). According to the findings, the inhibition of PC3 cell growth was directly proportional to the dose of Pd (II) complex. Its highest IC 50 value was attained after 48 h of incubation reached to 22.6 μg/mL. As a measure of DNA damage in PC3 cells, this IC50 value demonstrated a significant increase in early and late apoptotic cells with an intense comet nucleus. Given that the concentration of reactive oxygen species (ROS) in treated PC3 cells was much higher than in control ones. These results contributed to the notion that ROS-mediated cell death, which may have taken place via the mitochondrial pathway, was the mechanism by which the Pd (II) complex inhibited the proliferation of PC3 cancer cells. The prepared Pd (II) complex was fabricated and casted onto GC electrode for investigate the dopamine concentration in human serum. The limit of detection and limit of quantization were found to be 0.0127 and 0.0424 μM, respectively, which were in a good agreement with literature and were found to be an improvement to that present in the literature.

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Molecular studies regarding colon cancer cell line (HCT116) treated by new ruthenium and palladium complexes

Mohamed,

Kashmiry,

Hassan

2023

Applied Organom Chemis

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Ru(H2dtpa) (H2O) and Pd (DME)Cl2 were prepared, and their structures were confirmed by different structural tools. [Ru(H4dtpa) (cysteine)] Cl was separated as a model for the interaction of Ru (III) complex containing DTPA ligand with its corresponding most active amino acid and the geometrical parameters for the ternary complex and their constituent ligands are evaluated. Cytotoxicity was examined for both complexes against different cancer cell lines (HCT116, A549 and Mcf7). They were tested against a normal human lung cell line (W138). In addition, both complexes ensured cytocidal, not cytostatic effect. Several molecular tools were utilized in order to figure out the mechanism of action that two complexes followed to inhibit human colon cancer (HCT116) cell line. Gene expression analysis, cell cycle assay, genomic DNA analysis, and apoptosis were a molecular techniques that proved both Ru(H2dtpa) (H2O) and Pd (DME)Cl2 complexes were promising and effective chemotherapeutic agents against colon carcinoma in this current study. So, authors recommended more in vivo future studies should be done to make sure of complexes bioactivity and safety before they would be used commercially.

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The dual therapeutic effect of metformin nuclei‐based drugs modified with one of Tulbaghia violacea extract compounds

Cited by 11 publications

References 61 publications

Antimicrobial screening involving Helicobacter pylori of nano‐therapeutic compounds based on the amoxicillin antibiotic drug

Antimicrobial screening involving Helicobacter pylori of nano‐therapeutic compounds based on the amoxicillin antibiotic drug

The double‐edged sword of the amoxicillin antibiotic against prostate cancer in nano palladium form and its electrochemical detection of dopamine

Molecular studies regarding colon cancer cell line (HCT116) treated by new ruthenium and palladium complexes

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