The duality of macrophage function in chronic lymphocytic leukaemia

Chen, Yu-Chen Enya; Mapp, Sally; Blumenthal, Antje; Burgess, Melinda; Mazzieri, Roberta; Mattarollo, Stephen R.; Mollee, Peter; Gill, Devinder; Saunders, Nicholas A.

doi:10.1016/j.bbcan.2017.03.006

Cited by 14 publications

(20 citation statements)

References 91 publications

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“…They may present the pro-inflammatory properties of an M1-like phenotype in the initial stages of tumor growth, then convert to an M2-like phenotype when the tumor cells begin to invade and metastasize. Based on these findings, therapeutic approaches that target the switch of macrophages from an M2 to an M1 phenotype could be effective in inhibiting tumor growth [21]. …”

Section: Role Of Macrophages In Cancermentioning

confidence: 99%

The Role of Tumor-Associated Macrophages in Colorectal Carcinoma Progression

Zhong¹,

Chen²,

Yang³

2018

Cell Physiol Biochem

109

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Tumor-associated macrophages (TAMs) are one of the most abundant immune cells in the tumor microenvironment, and they play a pivotal role in prompting the various tumor growth. However, the role of TAMs in colorectal carcinoma (CRC) is controversial, because a few papers report that TAMs is beneficial to CRC patients. In this review, we discuss the good or bad roles of TAMs in CRC progression. Interestingly, recent studies provide strong evidence that TAMs facilitate CRC growth, but do not exert tumor suppressive activities. TAMs can stimulate CRC growth by altering extracellular matrix remodeling, tumor metabolism, angiogenesis, as well as the tumor microenvironment. Therefore, TAMs could serve as a target for CRC therapeutic treatment.

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Section: Role Of Macrophages In Cancermentioning

confidence: 99%

The Role of Tumor-Associated Macrophages in Colorectal Carcinoma Progression

Zhong¹,

Chen²,

Yang³

2018

Cell Physiol Biochem

109

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“…One theory explains the differentiation of monocytes by the process of maturation and differentiation of these cells into the peripheral blood macrophages [8]. The differences in the percentage of each subpopulation of monocytes observed in CLL patients, compared to the proportion observed in healthy subjects may be due to the fact that classical monocytes may differentiate into tissue macrophages TAMs (Tumor Associated Macrophages) [25,26].…”

Section: Discussionmentioning

confidence: 99%

Expression of CD163 and HLA-DR molecules on the monocytes in chronic lymphocytic leukemia patients

Kowalska

2020

Folia Histochem Cytobiol.

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Introduction. Human peripheral blood monocytes are the part of the leukemia microenvironment. We examined three monocyte subgroups: classical (CD14 ++ CD16 -), intermediate (CD14 ++ CD16 + ) and non-classical (CD14 + CD16 ++ ) monocytes. As these subpopulations can be also characterized by different levels of HLA-DR and CD163, we evaluated their expression on monocyte subpopulations of patients with chronic lymphocytic leukemia (CLL) and healthy individuals. Material and methods. The monocyte subsets in peripheral blood of CLL patients (n = 40) and healthy controls (n = 10) were evaluated by flow cytometry. The monoclonal antibodies: anti-CD14 FITC, anti-CD16 PE-Cy5, anti-CD163 PE, anti-HLA-DR PE were used. Results. The percentage of CD16-positive monocytes was significantly higher in CLL patients than in healthy donors. The highest percentage of CD163 + monocytes is in the 'classical' (CD14 ++ CD16 -) population. In turn, the non-classical monocytes constituted the majority of cells lacking HLA-DR expression. In CLL patients, there was no statistically significant relationship between the percentage of each monocyte subpopulation and the stage according to Rai Staging of CLL. Conclusions. The presence of CD163 on classical monocytes suggests that these cells have anti-inflammatory properties. Besides, the low expression of HLA-DR on non-classical monocytes may result in impaired ability to stimulate the immune system.

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“…Macrophage and dendritic cell progenitor cells (MDPs) give rise to monocytes which in turn differentiate into dendritic cells (DCs) and macrophages after recruitment to peripheral tissue sites. (Chen et al, 2017).…”

Section: The Role Of Macrophages In Cll Pathogenesismentioning

confidence: 99%

“…The NLCs then secrete cytokines and chemokines which in turn provide pro-survival signals for CLLs and hence the cycle continues. (Chen et al, 2017).…”

Section: Tams/nlcs As a Therapeutic Targetmentioning

confidence: 99%

“…FcγR signalling pathway in NLCs/TAMs.Diagram illustrates the FcγR activating pathway (ITAM) and the opposing inhibitory (ITIM) pathway present in NLCs derived from CLL patients. Signalling through ITAM is favoured in patients with stable disease whereas patients with progressive diseasedisplay reduced ITAM signalling resulting in increasing dominance of FcγRIIb-dependent ITIM signalling (Chen et al, 2017)…”

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confidence: 99%

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Regulation of responses to therapeutic antibodies by macrophages derived from chronic lymphocytic leukaemia patients

Chen¹

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Breakpoint cluster region protein BTK Bruton's tyrosine kinase CAV-1 Caveolin-1 CAV-2 Caveolin-2 CCL2 CC motif chemokine ligand 2 CCL3 CC motif chemokine ligand 3 CCL4 CC motif chemokine ligand 4 CCR1 CC chemokine receptor type 1 CCR2 CC chemokine receptor type 2 CCR4 CC chemokine receptor type 4 CCR5 CC chemokine receptor type 5 CD14 Cluster of differentiation 14 CD163 Cluster of differentiation 163 CD20 B-lymphocyte antigen CD20 CD4 Cluster of differentiation 4 CD47 Leukocyte surface antigen CD47 CD52 CAMPATH-1 antigen CD62L L-selectin CD68 Cluster of differentiation 68 CDK1 Cyclin-dependent kinase 1 CDK9 Cyclin-dependent kinase 9 CLL Chronic lymphocytic leukaemia COVID19 Coronavirus disease 2019 CSF1R Colony stimulating factor 1 receptor CSK C-terminal Src kinase CXCL12 C-X-C motif chemokine 12 CXCL13 C-X-C motif chemokine ligand 13 CXCL19 Chemokine (C-X-C motif) ligand 19 CXCL20 Chemokine (C-X-C motif) ligand 20 DC Dendritic cell Goat anti-mouse Alexa Fluor 488

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The duality of macrophage function in chronic lymphocytic leukaemia

Cited by 14 publications

References 91 publications

The Role of Tumor-Associated Macrophages in Colorectal Carcinoma Progression

The Role of Tumor-Associated Macrophages in Colorectal Carcinoma Progression

Expression of CD163 and HLA-DR molecules on the monocytes in chronic lymphocytic leukemia patients

Regulation of responses to therapeutic antibodies by macrophages derived from chronic lymphocytic leukaemia patients

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