The duodenal mucosa associated microbiome, visceral sensory function, immune activation and psychological comorbidities in functional gastrointestinal disorders with and without self-reported non-celiac wheat sensitivity

Shah, Ayesha; Kang, Seungha; Talley, Nick; Do, Anh; Walker, Marjorie M.; Shanahan, Erin R.; Koloski, Natasha A.; Jones, Michael; Keely, Simon; Morrison, Mark; Holtmann, Gerald

doi:10.1080/19490976.2022.2132078

Cited by 11 publications

(6 citation statements)

References 79 publications

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“…The extant studies revealed that factors, such as genetics, environment, psychosocial factors, diet, and gastrointestinal in ammation, contribute to the development of gastrointestinal symptoms through mechanisms, such as disrupted gastrointestinal motility, dysbiosis of the gut microbiota, visceral hypersensitivity, and brain-gut axis dysfunction[18, 45,47,48]. Numerous clinical studies have demonstrated the association between gastrointestinal symptoms and psychological factors that can affect patients' digestive systems by in uencing visceral sensory and gastric motor functions [49,50]. The limbic system of the central nervous system participates in bidirectional communication for visceral pain and perception, where external emotional stimuli can in uence gastric sensory processing, gastric motility, and secretion functions, and vice versa [51][52][53].…”

Section: Discussionmentioning

confidence: 99%

Chronic constipation and diarrhea are associated with depression in the elderly: Insights from a large cross-sectional study

陈,

Dai,

Tong

2024

Preprint

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Background: This study was to investigate the relationship between chronic constipation, diarrhea, and depression among the elderly, as the extent of their association remains elusive despite the well-established impact of gastrointestinal symptoms on depression. Methods: Cross-sectional analyses were conducted using data from the 2005-2010 U.S. National Health and Nutrition Examination Surveys (NHANES), focusing on adults aged 60 and above with a sample size of 4878. Depressive symptoms were measured using Patient Health Questionnaire 9 (PHQ-9) scale. Information about chronic diarrhea or constipation was retrieved from the bowel health questionnaire. Multivariable weighted logistic regression analysis models were employed to estimate the relationship between gut health and depression status, adjusting for potential confounders (e.g., age, gender, race, education, marital status, education level, smoking status, drinking habits, and medical history). Results: Probable depression (PHQ-9≥10) and depressive symptoms (PHQ-9≥5) were more prevalent among elderly individuals with diarrhea or constipation than among those without them (P <0.05). After adjusting for all-cause, the elderly with chronic diarrhea were more likely to have significant increases in their scores for several subtypes of depressive symptoms (P <0.05, six out of nine depressive symptoms). We observed a significantly positive correlation between patients with chronic constipation and the depressive symptoms for low mood/despair, appetite, and lack of concentration (P <0.05). Conclusion: The elderly with depressive symptoms (PHQ-9 ≥5) may be associated with chronic constipation and diarrhea based on a nationally representative sample of the elderly in the U.S. from 2005 to 2010. These findings suggest that elderly individuals experiencing chronic diarrhea and constipation may have a higher prevalence of psychological depression symptoms.

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Section: Discussionmentioning

confidence: 99%

Chronic constipation and diarrhea are associated with depression in the elderly: Insights from a large cross-sectional study

陈,

Dai,

Tong

2024

Preprint

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“…Recent work has shown that patients with DGBI who report WS have both a distinct mucosal microbiota and increased circulating gut-homing T cells when compared with non-WS and controls ( 24 ). Given that localized rectal immune responses to food (including wheat) have been observed in IBS ( 30 ), we aimed to determine whether gluten or gliadin provoked responses in FD-derived LPMCs.…”

Section: Discussionmentioning

confidence: 99%

“…TRAV26-2 is 1 variant that has been associated with biased gliadin processing ( 23 ), but the impact of TCR variants on the response to wheat in the absence of celiac-permissive MHC variants is unknown. Our recent work has demonstrated that patients with DGBI reporting WS have a higher proportion of circulating gut-homing T cells, compared with non-WS patients and controls ( 24 ). In this study, we collected duodenal biopsies to determine whether mucosal cells from patients with FD respond to stimulation with gluten or gliadin proteins ex vivo .…”

Section: Introductionmentioning

confidence: 99%

TRAV26-2 T-Cell Receptor Expression Is Associated With Mucosal Lymphocyte Response to Wheat Proteins in Patients With Functional Dyspepsia

Burns,

Potter,

Mathe

et al. 2023

Clin Transl Gastroenterol

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Introduction: An association between functional dyspepsia (FD) and wheat-containing foods has been reported in observational studies, however, an adaptive response has not been demonstrated. We examined whether antigens present in wheat could provoke a response from FD duodenal lymphocytes. Methods: Lamina propria mononuclear cells (LPMCs) were isolated from duodenal biopsies from 50 FD patients and 23 controls. LPMCs were exposed to gluten (0.2mg/mL) or gliadin (0.2mg/mL) for 24 hours. Flow cytometry was performed to phenotype lymphocytes. qPCR was used to measure expression of gliadin-associated T-cell receptor alpha variant (TRAV)26-2. Results: In response to gliadin (but not gluten) stimulation, the effector Th2-like population was increased in FD LPMCs compared to controls and unstimulated FD LPMCs. Duodenal gene expression of TRAV26-2 was decreased in FD compared to controls. We identified a positive association between gene expression of this T cell receptor variant and LPMC effector Th17-like cell populations in FD patients, but not controls following exposure to gluten, but not gliadin. Conclusion: Our findings suggest that gliadin exposure provokes a duodenal effector Th2-like response in FD patients, supporting the notion that food antigens drive responses in some patients. Further, these findings suggest that altered lymphocyte responses to wheat proteins play a role in FD pathogenesis.

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“…Currently, few data are available on the key role of the duodenal microbiota in the pathogenesis of GP and its link to duodenal microinflammation [ 67 , 68 ]. However, it seems highly probable that the complex duodenal bacterial environment may hold several not-yet-elucidated secrets regarding duodenogastric motility [ 69 ].…”

Section: Microbiota and Gastroparesismentioning

confidence: 99%

Gastroparesis: The Complex Interplay with Microbiota and the Role of Exogenous Infections in the Pathogenesis of the Disease

et al. 2023

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Gastroparesis (GP) is a disorder of gastric functions that is defined by objective delayed gastric emptying in the absence of mechanical obstruction. This disease is characterized by symptoms such as nausea, post-prandial fullness, and early satiety. GP significantly impacts patients’ quality of life and contributes to substantial healthcare expenses for families and society. However, the epidemiological burden of GP is difficult to evaluate, mainly due its significant overlap with functional dyspepsia (FD). GP and FD represent two similar diseases. The pathophysiology of both disorders involves abnormal gastric motility, visceral hypersensitivity, and mucosal inflammation. Moreover, both conditions share similar symptoms, such as epigastric pain, bloating, and early satiety. The latest evidence reveals that dysbiosis is directly or indirectly connected to gut–brain axis alterations, which are the basis of pathogenesis in both FD and GP. Furthermore, the role of microbiota in the development of gastroparesis was demonstrated by some clinical studies, which found that the use of probiotics is correlated with improvements in the gastric emptying time (GET). Infections (with viruses, bacteria, and protozoa) represent a proven etiology for GP but have not been sufficiently considered in current clinical practice. Previous viral infections can be found in about 20% of idiopathic GP cases. Moreover, delayed gastric emptying during systemic protozoal infections represents a huge concern for compromised patients, and few data exist on the topic. This comprehensive narrative review analyzes the relationship between microorganisms and GP. We explore, on the one hand, the correlation between gut microbiota dysbiosis and GP pathogenesis, including treatment implications, and, on the other hand, the association between exogenous infections and the etiology of the disease.

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The duodenal mucosa associated microbiome, visceral sensory function, immune activation and psychological comorbidities in functional gastrointestinal disorders with and without self-reported non-celiac wheat sensitivity

Cited by 11 publications

References 79 publications

Chronic constipation and diarrhea are associated with depression in the elderly: Insights from a large cross-sectional study

Chronic constipation and diarrhea are associated with depression in the elderly: Insights from a large cross-sectional study

TRAV26-2 T-Cell Receptor Expression Is Associated With Mucosal Lymphocyte Response to Wheat Proteins in Patients With Functional Dyspepsia

Gastroparesis: The Complex Interplay with Microbiota and the Role of Exogenous Infections in the Pathogenesis of the Disease

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