2020
DOI: 10.1016/j.ajog.2020.05.056
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The duration of intrapartum supplemental oxygen administration and umbilical cord oxygen content

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Cited by 11 publications
(10 citation statements)
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“…In a study of liberal versus indicated oxygen use, the average time was approximately 90 minutes. 8 Use for longer than 176 minutes was associated with lower oxygen levels in fetal blood. A proposed mechanism for this response is placental vasoconstriction thought to protect the fetus from free radical damage.…”
Section: Maternal and Fetal Oxidative Stressmentioning
confidence: 97%
“…In a study of liberal versus indicated oxygen use, the average time was approximately 90 minutes. 8 Use for longer than 176 minutes was associated with lower oxygen levels in fetal blood. A proposed mechanism for this response is placental vasoconstriction thought to protect the fetus from free radical damage.…”
Section: Maternal and Fetal Oxidative Stressmentioning
confidence: 97%
“…Most studies focused on the theoretical concern of free radical production secondary to fetal hyperoxygenation, with its potential sequential damage (18,19,20,21,22,23,24,25). A recent study demonstrated a negative association between the duration of oxygen exposure and neonatal oxygen partial pressure, suggesting impaired placental transfer of oxygen after prolonged fetal exposure (26).…”
Section: Clinical and Research Implicationsmentioning
confidence: 99%
“…[18][19][20][21][22][23][24][25] A recent study demonstrated a negative association between the duration of oxygen exposure and neonatal oxygen partial pressure, suggesting impaired placental transfer of oxygen after prolonged fetal exposure. 26 An additional proposed mechanism is the subsequent increased maternal cardiac parasympathetic activity following oxygen administration, leading to reduced cardiac output and increased systemic vascular resistance, which may attenuate blood and oxygen flow to the fetus. 27 Several review articles have been published in recent years, addressing the potentially harmful effect of intrapartum hyperoxygenation.…”
Section: Clinical and Research Implicationsmentioning
confidence: 99%
“…A planned secondary analysis of the previously described trial by Raghuraman and colleagues was also conducted to investigate cord blood oxygenation and acid–base values after different durations of O 2 exposure (cutoff: 75th percentile, 176 min) [ 28 ]. The authors concluded that newborns with longer durations of O 2 exposure had a lower partial pressure of O 2 in the UV (25.5 mmHg in the 12 patients receiving oxygen for >176 min vs. 32.5 mmHg in the 36 patients receiving oxygen for <176 min) [ 28 ]. This finding again suggested that impaired placental O 2 transfer occurs after prolonged O 2 exposure [ 28 ].…”
Section: Timing Of Oxygen Administrationmentioning
confidence: 99%