The Duration of Stone Disease and the Impact of a Stone Event on Patients' Quality of Life

Raizenne, Brendan; Deyirmendjian, Claudia; Bechis, Seth K.; Sur, Roger L.; Nakada, Stephen Y.; Antonelli, Jodi; Streeper, Nicole; Sivalingam, Sri; Viprakasit, Davis P.; Averch, Timothy D.; Landman, Jaime; Chi, Thomas; Pais, Vernon M.; Chew, Ben H.; Bird, Vincent G.; Andonian, Sero; Canvasser, Noah; Harper, Jonathan D.; Penniston, Kristina L.; Bhojani, Naeem

doi:10.1089/end.2021.0897

Cited by 8 publications

(14 citation statements)

References 19 publications

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“…Interestingly, in subgroup analyses, only RTA showed a trend towards more severe disease, with higher rates of disease recurrence (81% vs 65%, P = 0.04), bilateral KSD (89% vs 60%, P < 0.01) and stone-related symptoms (71% vs 51%, P = 0.1). This could be due to the earlier onset of KSD in the RTA population (29 vs 39 years, P < 0.05), which is also associated with impaired QOL [12,14]. Additionally, the impact of stone-related symptoms on HRQOL was highlighted by significantly higher D3-stonerelated impact scores in the MSK, RTA, and MalA subgroups, which is consistent with previous studies [6,15].…”

Section: Discussionsupporting

confidence: 87%

The impact of kidney stone disease on quality of life in high‐risk stone formers

Assad,

Raizenne,

El Yamani

et al. 2024

BJU International

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ObjectiveTo assess the impact of kidney stone disease (KSD) and its treatment on the health‐related quality of life (HRQOL) of high‐risk stone formers with hyperparathyroidism, renal tubular acidosis, malabsorptive disease, and medullary sponge kidney.Patients and MethodsThe Wisconsin Stone Quality of Life questionnaire was used to evaluate HRQOL in 3301 patients with a history of KSD from 16 institutions in North America between 2014 and 2020. Baseline characteristics and medical history were collected from patients, while active KSD was confirmed through radiological imaging. The high‐risk group was compared to the remaining patients (control group) using the Wilcoxon rank‐sum test.ResultsOf 1499 patients with active KSD included in the study, the high‐risk group included 120 patients. The high‐risk group had significantly lower HRQOL scores compared to the control group (P < 0.01). In the multivariable analyses, medullary sponge kidney disease and renal tubular acidosis were independent predictors of poorer HRQOL, while alkali therapy was an independent predictor of better HRQOL (all P < 0.01).ConclusionsAmong patients with active KSD, high‐risk stone formers had impaired HRQOL with medullary sponge kidney disease and renal tubular acidosis being independent predictors of poorer HRQOL. Clinicians should seek to identify these patients earlier as they would benefit from prompt treatment and prevention.

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Section: Discussionsupporting

confidence: 87%

The impact of kidney stone disease on quality of life in high‐risk stone formers

Assad,

Raizenne,

El Yamani

et al. 2024

BJU International

Self Cite

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“…Their results are consistent with an earlier report by Patel et al which recorded lower HRQoL in patients who had undergone >4 procedures or passed >10 stones [36]. A limitation to these studies is the lack of standardization of when the surveys were administered, as longer time since last intervention or stone event has been shown to be an independent predictor of better HRQoL [34 ▪▪ ]. Tapiero et al also reported HRQoL to be the lowest amongst patients who had experienced a stone event 4 weeks or less prior to taking the survey [21].…”

Section: Recurrencesupporting

confidence: 90%

“…In addition, this age demographic may be accustomed to the disease, and time lost from work would not be an issue amongst the retired [31]. Similar results have been reported in other studies [14,29,33,34 ▪▪ ]. However, in a smaller, single center study, Bensalah et al reported contrasting findings; older patients had lower total HRQoL on both univariate and multivariate analysis.…”

Section: Demographics and Socioeconomical Statussupporting

confidence: 55%

Measuring quality of life in patients with kidney stone disease: is it the future in endourology?

Vo,

Somani,

Ulvik

et al. 2023

Current Opinion in Urology

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Purpose of review Kidney stone disease is recognized to negatively impact quality of life. This pertains to acute episodes, surgical interventions and even during asymptomatic periods. Over time there has been increased attention towards assessing this subjective parameter, including as a determinant of treatment success. Our aim was to evaluate the current status and emerging trends in this field. Recent findings Patient groups most affected appear to be recurrent stone formers, cystine stone formers, women, younger populations, non-Caucasians and low-income populations. Several stone specific patient reported outcome measures are now available of which, WISQol has been implemented the most in clinical research studies. More invasive interventions such as percutaneous nephrolithotomy impede quality of life to greater extent than alternatives such as shockwave lithotripsy. Summary There are certain patient groups who are more vulnerable to the negative impact of kidney stone disease on their quality of life. Urologists can improve patient care by recognizing these particular populations as well as by implemented patient reported outcome measures in their routine clinical practice and when performing research.

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“…3 Additionally, older age at onset and longer disease duration are independent predictors of better HRQOL in kidney stone formers. 4 There is growing recognition that socioeconomic status (SES) and social vulnerability may play a role in the occurrence and progression of kidney stone disease. Lower income, non-White race, and unemployment status have been found to be associated with decreased QoL among urolithiasis patients.…”

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confidence: 99%

“…3 Additionally, older age at onset and longer disease duration are independent predictors of better HRQOL in kidney stone formers. 4…”

mentioning

confidence: 99%

Neighborhood Social Vulnerability Impacts Quality of Life in Kidney Stone Patients

Song,

Ceraolo,

Doersch

et al. 2024

Urology Practice

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Introduction: This study aimed to investigate the association between social vulnerability, as measured by the Centers for Disease Control and Prevention's Social Vulnerability Index (SVI), and the quality of life (QoL) of kidney stone patients using the validated Wisconsin Stone Quality of Life Questionnaire (WISQOL).Methods: A retrospective analysis was conducted on medical records of new urolithiasis patients who completed the WISQOL at the University of Rochester Medical Center kidney stone clinic. The primary outcome was WISQOL score, which was measured across multiple domains. SVI was used to assess social vulnerability. Neighborhoods with high SVI were defined by a threshold greater than or equal to the 75th percentile nationally. Demographic and clinical data were collected. Statistical analyses, including univariate tests and multivariate linear regression, were performed to evaluate the relationships between social vulnerability and disease-specific QoL.Results: A total of 1718 patients were included in the study. One hundred five subjects (6.1%) were from neighborhoods of high social vulnerability. Patients residing in neighborhoods with high social vulnerability (SVI quartile) reported significantly lower QoL scores (69.1 vs 77.2; P ¼ .001) and this persisted across all domains, including social impact (32.6 vs 35.1; P ¼ .002), emotional impact (25.2 vs 27.5; P ¼ .006), disease impact (28.5 vs 31.4; P ¼ .001), and vitality (10.3 vs 11.2; P ¼ .015). Younger age, female sex, and higher number of comorbidities were identified as independent predictors of lower QoL scores. However, non-White race and Latinx ethnicity did not exhibit a significant association with QoL scores.Conclusions: These findings highlight the negative impact of high social vulnerability on QoL, emphasizing the importance of considering socioeconomic factors in patient care. These results emphasize the need for targeted interventions to support vulnerable populations. While this study offers initial insights, further research is essential to corroborate these outcomes across larger and more diverse populations.

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The Duration of Stone Disease and the Impact of a Stone Event on Patients' Quality of Life

Cited by 8 publications

References 19 publications

The impact of kidney stone disease on quality of life in high‐risk stone formers

The impact of kidney stone disease on quality of life in high‐risk stone formers

Measuring quality of life in patients with kidney stone disease: is it the future in endourology?

Neighborhood Social Vulnerability Impacts Quality of Life in Kidney Stone Patients

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