The Dutch hypothesis (chronic non-specific lung disease) revisited

Sluiter, Hj; Koëter, Gerard H.; Monchy, J. G. R. De; Postma, Dirkje S.; Vries, Kd; Orie, N. G. M.

doi:10.1183/09031936.93.04040479

Cited by 138 publications

(5 citation statements)

References 66 publications

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“…The extent to which asthma contributes to the genesis of COPD has been much debated (84,85), but it is recognized that patients with severe, uncontrolled asthma can develop chronic airflow limitation without other environmental risk factors (31). In some patients with asthma, detailed physiological and pathological studies demonstrate varying degrees of loss of lung elastic recoil and emphysema (28,86).…”

Section: Copd and Asthma (Copd-a)mentioning

confidence: 99%

Definition and Nomenclature of Chronic Obstructive Pulmonary Disease: Time for Its Revision

Celli

Fabbri

Criner

et al. 2022

Am J Respir Crit Care Med

229

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Attempts to define concepts and things date back to the time of Aristotle, around 2,400 years ago, when he proposed that a definition should state the essential nature or being of something (1). However, this abstract concept (2-4) may not translate well to medical practice, where precise definitions are needed to communicate to colleagues and patients and to conduct epidemiological, clinical, translational, and discovery research in the presence of new evidence brought about by scientific progress. Since Aristotle's initial discussions, the last 24 centuries have witnessed the appearance and evolution of definitions of many things that surround us, including diseases (5). In medicine, accurate and precise definitions (nosology) and classification of diseases (taxonomy) allow thinking, speaking, and writing about observable phenomena in an understandable and unified way.

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Section: Copd and Asthma (Copd-a)mentioning

confidence: 99%

Definition and Nomenclature of Chronic Obstructive Pulmonary Disease: Time for Its Revision

Celli

Fabbri

Criner

et al. 2022

Am J Respir Crit Care Med

229

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“…The DH proposes that the same genetic host factor(s) interact(s) with varying environmental factors in all patients with asthma or COPD [3,5]. The common genetic root is considered to be an innate predisposition to AHR and to allergy.…”

Section: Same Pathogenesis For Asthma and Copd?mentioning

confidence: 99%

“…The widespread Dutch use of CARA, however, results from a hypothesis formulated by 0RIE and eo-workers of Groningen in 1961 [3,4 ], later coined as the Dutch hypothesis (DH), that asthma, chronic bronchitis and emphysema all result from a common genetic root and should be considered as one disease. Elsewhere in this issue [5], the senior investigators of the Groningen group have revisited their hypothesis three decades later, and set out their current views on the need to reinforce the DH and to retain the term CNSLD instead of the other wellestablished terms. Their vigorous defence of the DH should generate interest in view of the frequent reference to the hypothesis in recent literature.…”

mentioning

confidence: 99%

A "splitting" look at chronic nonspecific lung disease (CNSLD): common features but diverse pathogenesis

Vermeire¹,

Pride²

1991

Eur Respir J

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The term chronic nonspecific lung disease (CNSLD) was proposed by the Ciba Symposium in 1959 as an umbrella term grouping chronic bronchitis, asthma, emphysema and irreversible or persistent obstructive lung disease. However, it has only been widely used by proponents of the Dutch Hypothesis, which states that these diseases all result from a common genetic root and should be considered as one disease. A major reason for proposing this hypothesis in 1961 was that these different entities share some common features, especially airway hyperresponsiveness. Although not formally disproven, evidence is accumulating--and reviewed here--against this "one disease concept"; hence, common features should not necessarily imply a common pathogenesis. Overlap features are sufficiently frequent in clinical practice to cause problems for labelling patients within the scope of CNSLD. The term could still be used as a starting point for a "splitting approach", identifying a small number of important basic features in order to allow a more systematic use of established labels for diseases within CNSLD. Our proposal for labelling emphasizes a consistent use of asthma, emphysema and chronic obstructive pulmonary disease (COPD), but restricts the use of chronic bronchitis to those patients with chronic bronchial hypersecretion without chronic airways obstruction.

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“…A recent study reported that the Th2 inflammation-related genetic signature, a typical feature in asthma, co-occurred in COPD (9). "Dutch hypothesis" was proposed by Orie and colleagues that asthma and COPD are two different manifestations of one disease entity called "chronic non-specific lung disease" (CNSLD), which resulted from the interactions between genetic predisposition and exposure to similar environmental factors, further leading to the clinical presentations of the disease (10,11). By contrast, the "British hypothesis" stated that asthma and COPD are two distinct disease entities with different clinical syndromes, inflammatory processes, therapy responses, genetic substrate, and atopy status (4).…”

Section: Introductionmentioning

confidence: 99%

Polymorphisms in the FCER2 gene have associations with asthma and chronic obstructive pulmonary disease

Zheng¹,

Li²,

Liu³

et al. 2023

J Thorac Dis

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Background: Asthma and chronic obstructive pulmonary disease (COPD) are heterogenetic diseases and exhibit many similarities. Dutch hypothesis proposed that these two diseases may have common genetic origins. This study aims to investigate whether asthma and COPD share a common genetic background in Chinese patients. Methods:In this case-control study, single nucleotide polymorphisms (SNPs) were genotyped using SNaPshot. Haplotype disease analysis and haplotype phenotype analysis were applied to assess the relationship between three polymorphisms of the FCER2 gene and the risk of COPD/asthma. Additionally, associations between polymorphisms of the FCER2 gene and phenotypes were analyzed. Results:We detected ten SNPs of seven genes (FCER1A, FCGR2A, FCGR2B, CHI3L1, ADRB2, STAT6, and FCER2) expressed by airway epithelial cells. We detected genotypes and allele distributions in 251 COPD patients, 597 asthma patients, and 632 healthy controls. A significant difference was found in the FCER2 gene (rs28364072) between COPD patients and controls (P=0.009). Significant differences were observed in the genotype and allele distributions of rs1801274 (FCGR2A), rs12368672 (STAT6), and rs2228137 (FCER2) between asthma patients and controls (P=0.004, 0.007 and 0.010, respectively). Notably, polymorphisms of FCER2 gene were associated with the risk of both COPD (P=0.009 for rs28364072) and asthma (P=0.01 for rs2228137). Haplotype analysis revealed that haplotype T-G-T (alleles of rs28364072, rs2228137, and rs3760687, respectively) was significantly associated with a higher risk of asthma [odds ratios (OR) =2.25, 95% confidence interval (CI): 1.26-4.01, P=0.006]. Further analysis showed that the C-A-C haplotype and C-G-T haplotype were associated with increased blood eosinophils in either COPD or asthma patients (P=0.034, and P<0.001, respectively). Moreover, haplotypes C-A-C, C-G-C, and T-G-C showed significant associations with serum IgE levels in asthma patients (P=0.002, 0.041, and 0.004, respectively).Conclusions: Our data suggest that the FCER2 gene might associate with predisposition to asthma and COPD, while FCER2 haplotypes were associated with pulmonary function measurements and blood eosinophils counts in both diseases. Our findings support the common genetic basis for asthma and COPD, suggesting a potential therapeutic target for the two diseases.

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The Dutch hypothesis (chronic non-specific lung disease) revisited

Cited by 138 publications

References 66 publications

Definition and Nomenclature of Chronic Obstructive Pulmonary Disease: Time for Its Revision

Definition and Nomenclature of Chronic Obstructive Pulmonary Disease: Time for Its Revision

A "splitting" look at chronic nonspecific lung disease (CNSLD): common features but diverse pathogenesis

Polymorphisms in the FCER2 gene have associations with asthma and chronic obstructive pulmonary disease

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