2024
DOI: 10.3390/ijms25063327
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The DUX4–HIF1α Axis in Murine and Human Muscle Cells: A Link More Complex Than Expected

Thuy-Hang Nguyen,
Maelle Limpens,
Sihame Bouhmidi
et al.

Abstract: FacioScapuloHumeral muscular Dystrophy (FSHD) is one of the most prevalent inherited muscle disorders and is linked to the inappropriate expression of the DUX4 transcription factor in skeletal muscles. The deregulated molecular network causing FSHD muscle dysfunction and pathology is not well understood. It has been shown that the hypoxia response factor HIF1α is critically disturbed in FSHD and has a major role in DUX4-induced cell death. In this study, we further explored the relationship between DUX4 and HI… Show more

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