The dynamic changes of dominant clones of Staphylococcus aureus causing bloodstream infections in the European region: Results of a second structured survey

Grundmann, Hajo; Schouls, Leo M.; Aanensen, David M.; Pluister, Gerlinde N.; Tami, Adriana; Chlebowicz, Monika A.; Glasner, Corinna; Sabat, Artur J.; Weist, Klaus; Heuer, Ole Eske; Friedrich, Alex

doi:10.2807/1560-7917.es2014.19.49.20987

Cited by 101 publications

(90 citation statements)

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“…For example with additional testing, which is likely to have occurred due to an increased awareness of the possibility of antibiotic resistance, the number of detected and reported cases is likely to increase [18]. A biological factor possibly contributing to the decrease of MRSA in Germany is the reduction of epidemic clones throughout central Europe [19], as well as shifts of epidemic strains found within Germany [20].…”

Section: Discussionmentioning

confidence: 99%

“…Despite the decrease in 2014, the incidence of 4.8 invasive MRSA infections per 100,000 persons in Germany is still higher than that in some neighbouring countries, such as Denmark (1 case of MRSA bacteraemia per 100,000 in 2014) [22] (7) 245 (7) 285 (7) 304 (7) 279 (6) 279 (7) 50 to 59 2,159 (10) 400 (11) 458 (11) 485 (11) 445 (10) 371 (10) 60 to 69 3,877 (19) 731 (19) 788 (19) 803 (18) 809 (19) 748 (19) Baden-Württemberg 1,234 (6) 292 (8) 248 (6) 253 (6) 255 (6) 186 (5) < 0.001 Bavaria 1,730 (8) 378 (10) 385 (9) 358 (8) 356 (8) 253 (7) Berlin 1,486 (7) 285 (8) 304 (7) 306 (7) 321 (7) 270 (7) Brandenburg 772 (4) 152 (4) 173 (4) 139 (3) 153 (4) 155 (4) Bremen 101 (0) 22 (1) 22 (1) 24 (1) 15 (0) 18 (0) Hamburg 214 (1) 0 (0) 57 (1) 26 (1) 67 (2) 64 (2) Hesse 1,274 (6) 302 (8) 266 …”

Section: Discussionmentioning

confidence: 99%

“…44 (1) 493 (14) 494 (12) 457 (12) 325 (9) < 0.001 Pneumonia 3,494 (19) 588 (18) 681 (19) 778 (20) 760 (20) 687 (20) 0.15 Endocarditis 428 (2) 67 (2) 79 (2) 99 (2) 89 (2) 94 (3) 0.35…”

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Incidence of invasive meticillin-resistant Staphylococcus aureus infections in Germany, 2010 to 2014

et al. 2015

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Voluntary surveillance systems in Germany suggest a recent decline in the incidence of infections (subsequent to at least 2010) with meticillin-resistant Staphylococcus aureus (MRSA) from various types of specimens and settings. We asked whether this decline is reflected by data from the mandatory national surveillance system for invasive MRSA infections. Our analysis is based on the population in Germany in 2010 to 2014. Cases were identified from passive reporting by microbiological laboratories of the diagnosis of MRSA from blood culture or cerebrospinal fluid. Respective clinical data were subsequently added to the notification. We calculated risk ratios (RR) between consecutive years, stratifying cases by sex, age and federal state of residence. The national incidence increased from 4.6 episodes per 100,000 persons in 2010 to 5.6 in 2012 (2011 vs 2010: RR: 1.13, 95% confidence interval (CI): 1.08–1.18; 2012 vs 2011: RR: 1.08, 95% CI: 1.04–1.13). It stagnated at 5.4 per 100,000 in 2013 (RR: 0.97, 95% CI: 0.93–1.01) before declining to 4.8 in 2014 (RR: 0.88, 95% CI: 0.84–0.91). This trend was observed in most, but not all federal states and strata of sex and age groups. Only 204 of 20,679 (1%) episodes of infection were notified as belonging to an outbreak. Our analysis corroborates previous findings that the incidence of invasive MRSA infections in Germany may be declining.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Incidence of invasive meticillin-resistant Staphylococcus aureus infections in Germany, 2010 to 2014

et al. 2015

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“…Community-acquired Methicillin-Resistant Staphylococcus aureus (CA-MRSA) emerged in the community in the 1990s, and is now the leading cause of skin and soft tissue infections (SSTIs) in out-patient settings in the United States of America [2]. Nonetheless, methicillin-susceptible S. aureus (MSSA) still remains an important cause of S. aureus infections [3,4]. …”

Section: Introductionmentioning

confidence: 99%

Differences in prevalence of community-associated MRSA and MSSA among U.S. and non-U.S. born populations in six New York Community Health Centers

Jenks

Gándara

D’Orazio

et al. 2016

Travel Medicine and Infectious Disease

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Background Staphylococcus aureus is the most common cause of Skin and Soft Tissue Infections (SSTIs) in the community in the United States of America. Community Health Centers (CHC) serve as primary care providers for thousands of immigrants in New York. Methods As part of a research collaborative, 6 New York City-area CHCs recruited patients with SSTIs. Characterization was performed in all S. aureus isolates from wounds and nasal swabs collected from patients. Statistical analysis examined the differences in wound and nasal cultures among immigrant compared to native-born patients. Results Wound and nasal specimens were recovered from 129 patients and tested for antibiotic susceptibility. 40 patients were immigrants from 15 different countries. Although not statistically significant, immigrants had lower rates of MRSA infections (n=15) than did native-born participants, and immigrants showed significantly higher rates of MSSA wound cultures (n=11) (OR=3.5, 95% CI: 1.3, 9.7). Conclusions In our study, immigrants were more likely to present with SSTIs caused by MSSA than US-born patients. This suggests that antibiotic resistance may vary regionally and that immigrants presenting with SSTIs may benefit from a broader range of antibiotics. Immigrants also reported lower frequencies of antibiotic prescription or consumption in the months prior to SSTI infection.

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“…Hospital-acquired MRSA (HA-MRSA) isolates traditionally carry SCC mec types II and III, while type IV is often found in community-acquired MRSA [3]. However, these boundaries have become blurred with epidemiological studies showing a change in circulating lineages within hospitals [3], [4]. …”

Section: Introductionmentioning

confidence: 99%

Clinical and Microbiological Characteristics of Heteroresistant and Vancomycin-Intermediate Staphylococcus aureus from Bloodstream Infections in a Brazilian Teaching Hospital

et al. 2016

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This study analyzed clinical and microbiological characteristics of heteroresistant (hVISA) and vancomycin-intermediate Staphylococcus aureus (VISA) from bloodstream infections (BSI) in a Brazilian teaching hospital, between 2011 and 2013. Minimum inhibitory concentrations (MIC) of antimicrobials were determined by broth microdilution method and SCCmec was detected by PCR. Isolates with a vancomycin MIC ≥ 2mg/L were cultured on BHI agar with 3, 4 or 6 mg/L (BHIa3, BHIa4 or BHIa6) of vancomycin and BHIa4 with casein (BHIa4ca). Macromethod Etest® and Etest® Glicopeptides Resistance Detection were also used. VISA and hVISA isolates were confirmed by the population analysis profile then typed by pulsed-field gel electrophoresis (PFGE) and multilocus sequence typing. Medical data from the patients were obtained from their medical records. Among 110 consecutive isolates, 31 (28%) were MRSA and carried the SCCmec type II (15 isolates) or IV (16 isolates). Vancomycin MIC50 and MIC90 were 1 and 2 mg/L, respectively. MRSA isolates had increased non-susceptibility to daptomycin (p = 0.0003). Six (5%) isolates were VISA, four of which were MRSA, three SCCmec type II/USA100/ST5 and one type IV/USA800/ST3192. One MRSA SCCmec II isolate grew on agar BHIa3, BHIa4 and BHIa4ca, and it was confirmed as hVISA. Among the six VISA isolates, five (83%) grew on BHIa3 and three (50%) on BHI4ca. Four of the six VISA isolates and the one hVISA isolate were from patients who had undergone dialysis. Thus, a possible dissemination of the SCCmec II/USA100/ST5 lineage may have occurred in the hospital comprising the VISA, hVISA and daptomycin non-susceptible S. aureus Brazilian isolates from health care associated bloodstream infections.

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The dynamic changes of dominant clones of Staphylococcus aureus causing bloodstream infections in the European region: Results of a second structured survey

Cited by 101 publications

References 20 publications

Incidence of invasive meticillin-resistant Staphylococcus aureus infections in Germany, 2010 to 2014

Incidence of invasive meticillin-resistant Staphylococcus aureus infections in Germany, 2010 to 2014

Differences in prevalence of community-associated MRSA and MSSA among U.S. and non-U.S. born populations in six New York Community Health Centers

Clinical and Microbiological Characteristics of Heteroresistant and Vancomycin-Intermediate Staphylococcus aureus from Bloodstream Infections in a Brazilian Teaching Hospital

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