The dynamic receptive fields of retinal ganglion cells

Wienbar, Sophia; Schwartz, Greg

doi:10.1016/j.preteyeres.2018.06.003

Cited by 71 publications

(62 citation statements)

References 224 publications

(307 reference statements)

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“…This time shift resulted from loss of SAC center and enhancement of its surround activation following RVS. Center-surround receptive fields can dynamically change with the visual input (Rivlin-Etzion et al, 2018;Wienbar and Schwartz, 2018), and such deviations in the receptive field organization of retinal ganglion cells were also detected in vivo (Sagdullaev and Mccall, 2005).…”

Section: Discussionmentioning

confidence: 91%

Antagonistic center-surround mechanisms for direction selectivity in the retina

Ankri

Tsur

Maimon

et al. 2019

Preprint

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SummaryA key feature in sensory processing is center-surround receptive field antagonism. Retinal direction-selectivity (DS) relies on asymmetric inhibition from starburst amacrine cells (SAC) to direction selective ganglion cells (DSGC). SAC exhibit antagonistic center-surround, depolarizing to light increments and decrements in their center and surround, respectively, but the role of this property in DS remains elusive. We found that a repetitive stimulation exhausts SAC center and enhances its surround and used it to distinguish center-from surround-mediated responses. Center, but not surround stimulation, induced direction-selective responses in SAC, as predicted by an elementary spatiotemporal model. Nevertheless, both SAC center and surround elicited direction-selective responses in DSGCs, but to opposite directions. Physiological and morphology-based modeling data show that the opposed responses resulted from inverted DSGC’s excitatory-inhibitory temporal balance, indicating that SAC response time rules DS. Our findings reveal antagonistic center-surround mechanisms for DS, and demonstrate how context-dependent center-surround reorganization enables flexible computations.

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Section: Discussionmentioning

confidence: 91%

Antagonistic center-surround mechanisms for direction selectivity in the retina

Ankri

Tsur

Maimon

et al. 2019

Preprint

View full text Add to dashboard Cite

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“…Similarly, malleable stimulus selectivity has been observed in other sensory systems. For example, in the retina, although it is widely accepted that retinal ganglion cells consist of dedicated cell types with selectivity for a particular visual feature, recent work challenges this view (Rivlin-Etzion et al, 2018; Wienbar and Schwartz, 2018). Identified ON or OFF retinal ganglion cells can change their polarity based on stimulation outside the receptive field (Geffen et al, 2007) and ambient light levels (Tikidji-Hamburyan et al, 2015).…”

Section: Discussionmentioning

confidence: 99%

Odor Concentration Change Coding in the Olfactory Bulb

Parabucki

Bizer

Morris

et al. 2019

eNeuro

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Dynamical changes in the environment strongly impact our perception. Likewise, sensory systems preferentially represent stimulus changes, enhancing temporal contrast. In olfaction, odor concentration changes across consecutive inhalations ( ΔC t ) can guide odor source localization, yet the neural representation of ΔC t has not been studied in vertebrates. We have found that, in the mouse olfactory bulb, a subset of mitral/tufted (M/T) cells represents ΔC t , enhancing the contrast between different concentrations. These concentration change responses are direction selective: they respond either to increments or decrements of concentration, reminiscent of ON and OFF selectivity in the retina. This contrast enhancement scales with the magnitude, but not the duration of the concentration step. Further, ΔC t can be read out from the total spike count per sniff, unlike odor identity and intensity, which are represented by fast temporal spike patterns. Our results demonstrate that a subset of M/T cells represents ΔC t , providing a signal that may instruct navigational decisions in downstream olfactory circuits.

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“…RGCs constitute the innermost layer of the retina. They integrate visual information from photoreceptors and project these signals (firing spikes) to the brain via the optic nerve (Wienbar & Schwartz, 2018 ). RGCs project their 1.2 million axons, composing the optic nerve, to the brain, transmitting the visual signals gathered by the retina, ultimately leading to formed vision in the visual cortex (Maresca et al., 2013 ; Carelli et al., 2017 ).…”

Section: Discussionmentioning

confidence: 99%

Intravitreous delivery of melatonin affects the retinal neuron survival and visual signal transmission: in vivo and ex vivo study

Tao

et al. 2020

Drug Delivery

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Intravitreal delivery can maximize the intensity of therapeutic agents and extend their residence time within ocular tissue. Melatonin is a lipophilic molecule that crosses freely biological barriers and cell membranes. This study intends to investigate the effects of intravitreally delivered melatonin on mouse retina. The visual function of administered mice is assessed by electrophysiological and behavior examinations three weeks after intravitreal delivery. Moreover, multi-electrode array (MEA) was used to assess the electrical activities of retinal ganglion cells (RGCs). We found that intravitreal delivery of high dosage melatonin (400–500 µg/kg) destroyed the retinal architecture and impaired the visual function of mice. Conversely, the melatonin administration at low dose (100–300 µg/kg) did not have any significant effects on the photoreceptor survival or visual function. As shown in the MEA recording, the photoreceptors activity of the central region was more severely disturbed by the high dose melatonin. A pronounced augment of the spontaneous firing frequency was recorded in these mice received high dosage melatonin, indicating that intravitreal delivery of high dosage melatonin would affect the electrical activity of RGCs. Immunostaining assay showed that the vitality of cone photoreceptor was impaired by high dose melatonin. These findings suggest that intravitreal melatonin is not always beneficial for ocular tissues, especially when it is administered at high dosage. These data add new perspectives to current knowledge about melatonin delivery at the ocular level. Further therapeutic strategies should take into consideration of these risks that caused by delivery approach.

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The dynamic receptive fields of retinal ganglion cells

Cited by 71 publications

References 224 publications

Antagonistic center-surround mechanisms for direction selectivity in the retina

Antagonistic center-surround mechanisms for direction selectivity in the retina

Odor Concentration Change Coding in the Olfactory Bulb

Intravitreous delivery of melatonin affects the retinal neuron survival and visual signal transmission: in vivo and ex vivo study

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