The dynamics of accumulation of PCBs in cultured adipocytes vary with the cell lipid content and the lipophilicity of the congener

Bourez, Sophie; Daelen, Carine Van den; Lay, Soazig Le; Poupaert, Jacques H.; Larondelle, Yvan; Thomé, Jean-Pierre; Schneider, Yves‐Jacques; Dugail, Isabelle; Debier, Cathy

doi:10.1016/j.toxlet.2012.09.027

Cited by 42 publications

(36 citation statements)

References 20 publications

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“…However, even within a toxicant class, structural determinants dictate physico-chemical properties that determine AT accumulation. For example, different PCB congeners can display distinct uptake and storage dynamics into adipocytes (54) (250) (249). One study compared the accumulation potential in AT of three PCB congeners: PCB −28, −153, and −118 based on each of the congeners physico-chemical features.…”

Section: Physico-chemical Properties and Lipids Influence At Pop Bioamentioning

confidence: 99%

“…One study compared the accumulation potential in AT of three PCB congeners: PCB −28, −153, and −118 based on each of the congeners physico-chemical features. Results indicated that the dynamics of accumulation varied between the congeners due to molecular size, molecular volume, and lipophilicity (54). Specifically, the degree of halogenation, or number and position of chlorine substituents on the PCBs, influenced their uptake and accumulation in adipocytes.…”

Section: Physico-chemical Properties and Lipids Influence At Pop Bioamentioning

confidence: 99%

“…Specifically, the degree of halogenation, or number and position of chlorine substituents on the PCBs, influenced their uptake and accumulation in adipocytes. PCB-28 entered adipocytes more rapidly than the other two congeners likely due to its smaller molecular weight, size, and lipophilicity, while PCBs −153 and −118 remained trapped in the lipophilic cell membrane and diffused more slowly into the intracellular, hydrophobic cytoplasm of the adipocyte (54). …”

Section: Physico-chemical Properties and Lipids Influence At Pop Bioamentioning

confidence: 99%

“…preadipocytes, fibroblasts, macrophages, etc. ), storage of POPs is believed to primarily occur in adipocytes (54) whose cytoplasm is composed mainly of triglyceride droplets (341). There are reports indicating that TCDD and DDT are transported out of the gut into the triglyceride component of chylomicrons, which are responsible for delivering lipids absorbed from the intestine to AT (416) (205).…”

Section: Physico-chemical Properties and Lipids Influence At Pop Bioamentioning

confidence: 99%

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Adipose Tissue as a Site of Toxin Accumulation

Jackson

Shoemaker

Larian

et al. 2017

Comprehensive Physiology

142

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We examine the role of adipose tissue, typically considered an energy storage site, as a potential site of toxicant accumulation. Although the production of most persistent organic pollutants (POPs) was banned years ago, these toxicants persist in the environment due to their resistance to biodegradation and widespread distribution in various environmental forms (e.g., vapor, sediment, water). As a result, human exposure to these toxicants is inevitable. Largely due to their lipophilicity, POPs bioaccumulate in adipose tissue, resulting in greater body burdens of these environmental toxicants with obesity. POPs of major concern include polychlorinated biphenyls (PCBs), polychlorinated dibenzo-p-dioxins and furans (PCDDs/PCDFs), and polybrominated biphenyls and diphenyl ethers (PBBs/PBDEs), among other organic compounds. In this review, we 1) highlight the physical characteristics of toxicants that enable them to partition into and remain stored in adipose tissue, 2) discuss the specific mechanisms of action by which these toxicants act to influence adipocyte function, and 3) review associations between POP exposures and the development of obesity and diabetes. An area of controversy relates to the relative potential beneficial versus hazardous health effects of toxicant sequestration in adipose tissue.

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Section: Physico-chemical Properties and Lipids Influence At Pop Bioamentioning

confidence: 99%

Section: Physico-chemical Properties and Lipids Influence At Pop Bioamentioning

confidence: 99%

Section: Physico-chemical Properties and Lipids Influence At Pop Bioamentioning

confidence: 99%

Section: Physico-chemical Properties and Lipids Influence At Pop Bioamentioning

confidence: 99%

See 2 more Smart Citations

Adipose Tissue as a Site of Toxin Accumulation

Jackson

Shoemaker

Larian

et al. 2017

Comprehensive Physiology

142

View full text Add to dashboard Cite

show abstract

“…These limits are fixed to protect consumer health from exposure to foods containing PCBs. Experimental studies have been mainly performed to evaluate the accumulation dynamics, storage and release in/from adipose cells of NDL-PCBs (Bourez et al, 2012(Bourez et al, , 2013Gallenberg and Vodicnik, 1987).…”

Section: Contents Lists Available At Sciencedirectmentioning

confidence: 99%