The Dynamics of Antimicrobial Resistance among Enterobacteriaceae Isolates in Russia: Results of the 2012–2018 INFORM and ATLAS International Program Studies

Kozlov, Roman; Kuzmenkov, Alexey Yu.

doi:10.3390/antibiotics11060790

Cited by 4 publications

(3 citation statements)

References 39 publications

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“…Sulfonamides (mainly sulfamethoxazole trimethoprim) were reported by many researchers among the most common culprit drugs for SJS and TEN among anti-infectives. Our data revealed only one case of SJS associated with sulfanilamide and one case associated with sulfamethoxazole trimethoprim; a possible explanation of such a low prevalence may be related to the fact of a limited prescription of sulfonamides in Russia due to a high rate of antibiotic resistance [ 49 , 50 ].…”

Section: Discussionmentioning

confidence: 99%

Stevens–Johnson Syndrome and Toxic Epidermal Necrolysis: Analysis of the Russian Database of Spontaneous Reports

Zyryanov,

Asetskaya,

Butranova

et al. 2024

Pharmaceuticals

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(1) Background: Stevens–Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are extremely severe cutaneous adverse drug reactions which are relatively rare in routine clinical practice. An analysis of a national pharmacovigilance database may be the most effective method of obtaining information on SJS and TEN. (2) Methods: Design—a retrospective descriptive pharmacoepidemiologic study of spontaneous reports (SRs) with data on SJS and TEN retrieved from the Russian National Pharmacovigilance database for the period from 1 April 2019 to 31 December 2023. Descriptive statistics was used to assess the demographic data of patients and the structure of suspected drugs. (3) Results: A total of 170 SRs on SJS and TEN were identified, of which 32.9% were SJS and 67.1%—TEN. In total, 30% were pediatric SRs, 21.2%—SRs of the elderly. There were 12 lethal cases, and all cases were TEN. The leading culprit drugs were anti-infectives for systemic use and nervous system agents. The top 10 involved drugs are as follows: lamotrigine (23.5%), ibuprofen (12.9%), ceftriaxone (8.8%), amoxicillin and amoxicillin with beta-lactam inhibitors (8.8%), paracetamol (7.6%), carbamazepine (5.9%), azithromycin (4.1%), valproic acid (4.1%), omeprazole (3.5%), and levetiracetam (3.5%). (4) Conclusions: Our study was the first study in Russia aimed at the assessment of the structure of the drugs involved in SJS and TEN on the national level.

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Section: Discussionmentioning

confidence: 99%

Stevens–Johnson Syndrome and Toxic Epidermal Necrolysis: Analysis of the Russian Database of Spontaneous Reports

Zyryanov,

Asetskaya,

Butranova

et al. 2024

Pharmaceuticals

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“…The MDR pathogens deprived from ECMO patients were dominated by MDR-GNB, which were common seen in ICU patients [9]. Some scholars thought that the disruption of gut barrier [10] and translocation of gastrointestinal microbiota [11] were associated with MDR-GNB infections.…”

Section: Discussionmentioning

confidence: 99%

Etiological characteristics and appropriate empiric antibiotic strategies of multidrug-resistant pathogens in patients requiring extracorporeal membrane oxygenation: a retrospective cohort study

Gao

Wang

2023

Preprint

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Background: Delayed treatments of MDR infections in patients receiving extracorporeal membrane oxygenation (ECMO) supports associated with increased mortality. But, there was currently no relevant references available to guide early anti-infective treatments for them. The purpose of our study was to clarify etiological characteristics and empiric antibiotic strategies of MDR pathogens in ECMO patients. Methods: The clinical data of 104 ECMO patients in Tianjin third central hospital were retrospectively collected from January 2014 to December 2022. There were 61 and 29 adult patients supported by veno-arterial (VA)-ECMO or veno-venous (VV)-ECMO for > 24 hours enrolled. Patients were divided into “group R” and “group N” by with or without MDR infections. Clinical characteristics of enrolled patients were collected. The data of MDR pathogens and anti-infection treatments against them were summarized. Results: The rates of MDRinfections were 50.8% and 79.3% in VA-ECMO and VV-ECMO patients respectively. ECMO patients in group R presented poor prognostic indicators as expected. MDR pathogens detected were mainly MDR Gram-negative bacteria (MDR-GNB) (91.6% in VA-ECMO patients and 92.5% in VV-ECMO patients, respectively). Sputum was the main source of MDR. There were 72.9% and 80% of MDR pathogens deprived from sputum in VA-ECMO and VV-ECMO patients respectively. MDR pathogens generally showed high drug-resistant prevalence to routine antibiotics, and anti-infection treatments against them were not optimistic. Cephalosporins, meropenem, linezolid and tigecycline were most selected antibiotics according to antimicrobial susceptibility tests in our study. Conclusion: ECMO patients had high incidence of MDR infection, which mostly induced by MDR-GNB from sputum. Cephalosporins, meropenem, linezolid and tigecycline were appropriate empiric antibiotics against MDR pathogens in ECMO patients according to our study.

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“…MDR-GNB were the most common bacteria in ECMO patients in our study, and also dominated in overall ICU patients. 13 The disruption of the gut barrier and translocation of gastrointestinal microbiota have been associated with MDR-GNB infections in critically ill patients. 14,15 The gut barrier is damaged by hypoperfusion and hyperoxia-induced oxidative stress in ECMO patients as well.…”

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confidence: 99%

The Etiological and Drug Resistance Characteristics of Multidrug-Resistant Pathogens in Patients Requiring Extracorporeal Membrane Oxygenation: A Retrospective Cohort Study

Gao¹,

Wang²

2023

IDR

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Infections induced by multidrug-resistant (MDR) pathogens are one of the most common and serious complications in extracorporeal membrane oxygenation (ECMO) patients. However, there is currently little research about "ECMO and MDR bacteria". The purpose of our study was to clarify the epidemiological characteristics of MDR bacteria and provide references for empiric antibiotic treatments according to the drug susceptibility tests for ECMO patients. Patients and Methods: There were 104 patients admitted to our department and receiving ECMO treatments between January 2014 and December 2022. Altogether, 61 veno-arterial ECMO (VA-ECMO) and 29 veno-venous ECMO (VV-ECMO) patients enrolled. The data on other intensive care unit (ICU) patients in our department in the same period are summarized. Results: A total of 82 MDR bacteria were detected from ECMO patients, and most of these were MDR Gram-negative bacteria (MDR-GNB). There were also 5559 MDR-GNB collected from other patients in our department in the same period. We found that the distribution of MDR-GNB in ECMO patients was different from other critical patients. The proportion of Klebsiella pneumoniae (MDR-KP) in VV-ECMO patients was higher than other critical patients (35.1% and 21.3%, respectively). Moreover, the proportions of MDR Acinetobacter baumannii (MDR-AB) of VA-ECMO and VV-ECMO were higher than other critical patients (54.6%, 43.2% and 30.5%, respectively). In addition, MDR-AB and MDR-KP in ECMO patients exhibited higher percentages of drug resistance to possibly appropriate antibiotics for other critical patients, but showed better sensitivity to colistin. Conclusion: Infections induced by MDR-GNB in ECMO patients were serious and exhibited higher degrees of drug resistance compared with other ICU patients. Colistin might be an option to consider if there is no medical contraindication. However, widespread use of broad spectrum antibiotics is something that should be discouraged, and alternative options are being explored.

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The Dynamics of Antimicrobial Resistance among Enterobacteriaceae Isolates in Russia: Results of the 2012–2018 INFORM and ATLAS International Program Studies

Cited by 4 publications

References 39 publications

Stevens–Johnson Syndrome and Toxic Epidermal Necrolysis: Analysis of the Russian Database of Spontaneous Reports

Stevens–Johnson Syndrome and Toxic Epidermal Necrolysis: Analysis of the Russian Database of Spontaneous Reports

Etiological characteristics and appropriate empiric antibiotic strategies of multidrug-resistant pathogens in patients requiring extracorporeal membrane oxygenation: a retrospective cohort study

The Etiological and Drug Resistance Characteristics of Multidrug-Resistant Pathogens in Patients Requiring Extracorporeal Membrane Oxygenation: A Retrospective Cohort Study

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