The dynamics of blood biochemical parameters in an experiment with seven-day immersion

Маркин, А. А.; Моруков, Б. В.; Журавлева, О. А.; Zabolotskaya, I. V.; Вострикова, Л. В.; Lyapunova, N. A.; Tsvetkova, T. G.

doi:10.1134/s0362119710070200

Cited by 3 publications

(6 citation statements)

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“…At the same time, we could observe higher blood levels of both insulin and IGF1. These results suggest an activation of hepatic metabolism via the stimulation of growth hormone as such findings were already reported in previous DI studies [ 20 , 31 ]. This favors the hypothesis that insulin resistance develops during DI, similarly to that observed after 6 days of head-down bed rest [ 32 ].…”

Section: Discussionsupporting

confidence: 89%

“…Markers of bone tissue resorption such as TRAP and CTx were shown to slightly increase during Russian DI for 7 days [ 19 ]. However, Markin et al [ 20 ] did not find any changes in the activity of total acid phosphatase during a similar period of immersion. From urinary NTx and Deoxypyridinoline (Dpyr) as bone turnover markers, previous reports have shown that already 24 hours of bed rest induce a significant rise in resorption activity in healthy subjects [ 3 , 4 ].…”

Section: Discussionmentioning

confidence: 94%

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Effects of short-term dry immersion on bone remodeling markers, insulin and adipokines

et al. 2017

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BackgroundDry immersion (DI), a ground-based model of microgravity previously used in Russia, has been recently implemented in France. The aim of this study was to analyze early events in a short-term DI model in which all conditions are met to investigate who is first challenged from osteo- or adipo-kines and to what extent they are associated to insulin-regulating hormones.MethodsTwelve healthy men were submitted to a 3-day DI. Fasting blood was collected during pre-immersion phase for the determination of the baseline data collection (BDC), daily during DI (DI24h, DI48H and DI72h), then after recovery (R+3h and R+24h). Markers of bone turnover, phosphocalcic metabolism, adipokines and associated factors were measured.ResultsBone resorption as assessed by tartrate-resistant acid phosphatase isoform 5b and N-terminal crosslinked telopeptide of type I collagen levels increased as early as DI24h. At the same time, total procollagen type I N- and C-terminal propeptides and osteoprotegerin, representing bone formation markers, decreased. Total osteocalcin [OC] was unaffected, but its undercarboxylated form [Glu-OC] increased from DI24h to R+3h. The early and progressive increase in bone alkaline phosphatase activities suggested an increased mineralization. Dickkopf-1 and sclerostin, as negative regulators of the Wnt-β catenin pathway, were unaltered. No change was observed either in phosphocalcic homeostasis (calcium and phosphate serum levels, 25-hydroxyvitamin D, fibroblast growth factor 23 [FGF23]) or in inflammatory response. Adiponectemia was unchanged, whereas circulating leptin concentrations increased. Neutrophil gelatinase-associated lipocalin [lipocalin-2], a potential regulator of bone homeostasis, was found elevated by 16% at R+3h compared to DI24h. The secretory form of nicotinamide phosphoribosyl-transferase [visfatin] concentrations almost doubled after one day of DI and remained elevated. Serum insulin-like growth factor 1 levels progressively increased. Fasting insulin concentrations increased during the entire DI, whereas fasting glucose levels tended to be higher only at DI24h and then returned to BDC values. Changes in bone resorption parameters negatively correlated with changes in bone formation parameters. Percent changes of ultra-sensitive C-reactive protein positively correlated with changes in osteopontin, lipocalin-2 and fasting glucose. Furthermore, a positive correlation was found between changes in FGF23 and Glu-OC, the two main osteoblast-/osteocyte-derived hormones.ConclusionOur results demonstrated that DI induced an unbalanced remodeling activity and the onset of insulin resistance. This metabolic adaptation was concomitant with higher levels of Glu-OC. This finding confirms the role of bone as an endocrine organ in humans. Furthermore, visfatin for which a great responsiveness was observed could represent an early and sensitive marker of unloading in humans.

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Section: Discussionsupporting

confidence: 89%

Section: Discussionmentioning

confidence: 94%

Effects of short-term dry immersion on bone remodeling markers, insulin and adipokines

et al. 2017

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“…This might indicate that mechanical unloading of bones leads to the activation of osteoclastic processes. However, Markin et al (2008) did not find any changes in the activity of total acid phosphatase during the 7 days of dry immersion.…”

Section: Bone Resorption Markerscontrasting

confidence: 46%

“…2. More recently, Markin et al (2008) also found a tendency for the concentrations of total plasma cholesterol and low density lipoprotein to increase, and an increase in triglycerides, although within normal limits. Pakharukova et al (2009a), in a serum proteome study, reported an increase in apolipoproteins C1 and C3 on day 7 of dry immersion, which suggested complex changes in lipid metabolism.…”

Section: Lipid Profilementioning

confidence: 93%

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Long-term dry immersion: review and prospects

et al. 2010

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Dry immersion, which is a ground-based model of prolonged conditions of microgravity, is widely used in Russia but is less well known elsewhere. Dry immersion involves immersing the subject in thermoneutral water covered with an elastic waterproof fabric. As a result, the immersed subject, who is freely suspended in the water mass, remains dry. For a relatively short duration, the model can faithfully reproduce most physiological effects of actual microgravity, including centralization of body fluids, support unloading, and hypokinesia. Unlike bed rest, dry immersion provides a unique opportunity to study the physiological effects of the lack of a supporting structure for the body (a phenomenon we call 'supportlessness'). In this review, we attempt to provide a detailed description of dry immersion. The main sections of the paper discuss the changes induced by long-term dry immersion in the neuromuscular and sensorimotor systems, fluid-electrolyte regulation, the cardiovascular system, metabolism, blood and immunity, respiration, and thermoregulation. The long-term effects of dry immersion are compared with those of bed rest and actual space flight. The actual and potential uses of dry immersion are discussed in the context of fundamental studies and applications for medical support during space flight and terrestrial health care.

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Dry Immersion as a Ground-Based Model of Microgravity Physiological Effects

et al. 2019

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Dry immersion (DI) is one of the most widely used ground models of microgravity. DI accurately and rapidly reproduces most of physiological effects of short-term space flights. The model simulates such factors of space flight as lack of support, mechanical and axial unloading as well as physical inactivity. The current manuscript gathers the results of physiological studies performed from the time of the model’s development. This review describes the changes induced by DI of different duration (from few hours to 56 days) in the neuromuscular, sensory-motor, cardiorespiratory, digestive and excretory, and immune systems, as well as in the metabolism and hemodynamics. DI reproduces practically the full spectrum of changes in the body systems during the exposure to microgravity. The numerous publications from Russian researchers, which until present were mostly inaccessible for scientists from other countries are summarized in this work. These data demonstrated and validated DI as a ground-based model for simulation of physiological effects of weightlessness. The magnitude and rate of physiological changes during DI makes this method advantageous as compared with other ground-based microgravity models. The actual and potential uses of the model are discussed in the context of fundamental studies and applications for Earth medicine.

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The dynamics of blood biochemical parameters in an experiment with seven-day immersion

Cited by 3 publications

References 2 publications

Effects of short-term dry immersion on bone remodeling markers, insulin and adipokines

Effects of short-term dry immersion on bone remodeling markers, insulin and adipokines

Long-term dry immersion: review and prospects

Dry Immersion as a Ground-Based Model of Microgravity Physiological Effects

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