The dynamics of the coronary venous system in the dog

Wong, Alan Y.K.; Armour, J. A.; Klassen, Gerald A.; Lee, B.

doi:10.1016/0021-9290(84)90008-3

Cited by 16 publications

(2 citation statements)

References 23 publications

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“…With vessels embedded in tissue as intramyocardial vessels, transmural pressure at volumes less than unstressed volume may be negative (Rothe, 1983). To return the vessel from a flat to cylindrical configuration requires only a small change in the inside pressure (Katz et al, 1969;Wong et al, 1984). This characteristic of the vein may contribute to the 482 unstressed volume.…”

Section: Discussionmentioning

confidence: 99%

Functional characteristics of intramyocardial capacitance vessels during diastole in the dog.

Kajiya¹,

Tsujioka²,

Goto³

et al. 1986

Circulation Research

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In order to evaluate the functional characteristics of the intramyocardial capacitance vessels during prolonged diastole, we analyzed the response of coronary vein flow after stepwise changes of coronary artery pressure in anesthetized open-chest dogs by using our newly developed laser Doppler velocimeter with an optical fiber. The peripheral portion of the great cardiac vein was isolated and the optical fiber tip was inserted into the vessel. The left anterior descending coronary artery was cannulated and connected to a reservoir to regulate coronary perfusion pressure. Intracoronary adenosine administration was carried out to avoid any change in coronary vasomotor tone. After 15 seconds of occlusion of the perfusion route, the heart was arrested by pacing-off. Two seconds later, coronary perfusion pressure was increased stepwise to a preset target pressure. This procedure was repeated by changing target pressure at 4 (or 5) different pressure levels (31-105 mm Hg). The great cardiac vein flow became zero due to the cardiac arrest and remained at zero for a moment (dead time) after the initiation of reperfusion. Then the flow reappeared and increased with first order time delay. The presence of dead time indicates the existence of unstressed volume, and the first order time delay represents the product of resistance and capacitance. The unstressed volume with a minimal vasomotor tone for perfusion pressure of 60-90 mm Hg was 5.2 +/- 2.2 ml per 100 g left ventricle, which is comparable to coronary blood flow for several beats. The capacitance at perfusion pressure of 60-90 mm Hg was 0.08 +/- 0.04 ml/mm Hg per 100 g left ventricle, while that at low perfusion pressure (30-50 mm Hg) was 0.14 +/- 0.09 ml/mm Hg per 100 g left ventricle. These results indicate that the intramyocardial capacitance vessels have two functional components, and that the phasic nature of coronary vein flow is solely the result of the myocardial squeezing of the blood in the capacitance vessels.

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Section: Discussionmentioning

confidence: 99%

Functional characteristics of intramyocardial capacitance vessels during diastole in the dog.

Kajiya¹,

Tsujioka²,

Goto³

et al. 1986

Circulation Research

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“…The results found that the WSS is much higher in systole than during diastole [30]. Mori The BAV geometries were constructed from a previously published model of a bioprosthetic heart valve as shown in Figure 3 BAV Types I and II root geometry For this simulation the coronary arteries were not included since it was assumed that majority of the flow in the coronaries occur during diastole while this simulation is during systole [34]. The arterial bifurcations at the arch were also not included as our region of interest was confined to the ascending aortic segment.…”

Section: Computational Fluid Dynamic Studiesmentioning

confidence: 99%

Determining the effect of congenital bicuspid aortic valves on aortic dissection using computational fluid dynamics

Burken¹

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providing me with their expertise. Thanks also goes out to Paul and Vijay who helped create and problem solve the geometries. I would like to express my thanks to the BME secretaries April and Angie for their help with the paperwork. I am grateful or my sister Kim for her proofreading skills. I am forever indebted to my parents, Deb and Pat, who have always encouraged me to strive, and given me their unwavering support in whatever I attempt. I would also like to thank my grandparents and the rest of family for their support. Finally I would like to thank Ben who helped proofread , and who put up with me when I was stressed out.

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The promise and limitations of coronary venous retroperfusion: lessons from the past and new directions

Meerbaum¹

1986

CSI — A New Approach to Interventional Cardiology

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The dynamics of the coronary venous system in the dog

Cited by 16 publications

References 23 publications

Functional characteristics of intramyocardial capacitance vessels during diastole in the dog.

Functional characteristics of intramyocardial capacitance vessels during diastole in the dog.

Determining the effect of congenital bicuspid aortic valves on aortic dissection using computational fluid dynamics

The promise and limitations of coronary venous retroperfusion: lessons from the past and new directions

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