The dynamics of the main biliary duct and the mechanism of the biliopancreatic reflux

Pinotti, H W; Sousa, Odorico Machado de; Parolari, João Baptista; Conte, Vinício Páride; A, Raia; Netto, A. Correa

doi:10.1007/bf02236446

Cited by 7 publications

(1 citation statement)

References 9 publications

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“…A biliopancreatic reflux study reported BA reflux in the pancreas in six patients. They found that the reflux could be extensive enough to reach the tail of the pancreas [83]. Furthermore, bile duct ligation and pancreatic duct ligation resulted in the increased severity of pancreatitis, suggesting that systemically circulating BAs interact with the pancreas and can exacerbate the condition [84].…”

Section: Bile Acids and Pancreasmentioning

confidence: 99%

Bile Acids and Microbiota Interplay in Pancreatic Cancer

Malhotra

Palanisamy

Caparrós-Martín

et al. 2023

Cancers

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Evidence suggests the involvement of the microbiota, including oral, intra-tumoral and gut, in pancreatic cancer progression and response to therapy. The gut microbiota modulates the bile acid pool and is associated with maintaining host physiology. Studies have shown that the bile acid/gut microbiota axis is dysregulated in pancreatic cancer. Bile acid receptor expression and bile acid levels are dysregulated in pancreatic cancer as well. Studies have also shown that bile acids can cause pancreatic cell injury and facilitate cancer cell proliferation. The microbiota and its metabolites, including bile acids, are also altered in other conditions considered risk factors for pancreatic cancer development and can alter responses to chemotherapeutic treatments, thus affecting patient outcomes. Altogether, these findings suggest that the gut microbial and/or bile acid profiles could also serve as biomarkers for pancreatic cancer detection. This review will discuss the current knowledge on the interaction between gut microbiota interaction and bile acid metabolism in pancreatic cancer.

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Section: Bile Acids and Pancreasmentioning

confidence: 99%