The dynamics of theta-related pro-active control and response inhibition processes in AD(H)D

Adelhöfer, Nico; Bluschke, Annet; Roessner, Veit; Beste, Christian

doi:10.1016/j.nicl.2021.102609

Cited by 12 publications

(15 citation statements)

References 79 publications

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“…We focus on theta (4-7 Hz) band, which has been shown to index executive control and response suppression. 22,29,30 Theta synchronization also improves over frontal areas after working memory training 31 and over fronto-parietal areas after mindfulness meditation. 32 Moreover, both Gist reasoning training and learning training have been shown in increase theta synchronization in GoNoGo tasks among older adults with cognitive impairment, suggesting that theta oscillations might index training effects.…”

Section: Introductionmentioning

confidence: 92%

“…to test the hypothesis that training‐related changes in older adults’ ERPs are related to alteration in oscillatory power and functional connectivity. We focus on theta (4–7 Hz) band, which has been shown to index executive control and response suppression 22,29,30 . Theta synchronization also improves over frontal areas after working memory training 31 and over fronto‐parietal areas after mindfulness meditation 32 .…”

Section: Introductionmentioning

confidence: 99%

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Music training modulates theta brain oscillations associated with response suppression

Moussard

Guo

et al. 2022

Annals of the New York Academy of Sciences

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There is growing interest in developing training programs to mitigate cognitive decline associated with normal aging. Here, we assessed the effect of 3‐month music and visual art training programs on the oscillatory brain activity of older adults using a partially randomized intervention design. High‐density electroencephalography (EEG) was measured during the pre‐ and post‐training sessions while participants completed a visual GoNoGo task. Time‐frequency representations were calculated in regions of interest encompassing the visual, parietal, and prefrontal cortices. Before training, NoGo trials generated greater theta power than Go trials from 300 to 500 ms post‐stimulus in mid‐central and frontal brain areas. Theta power indexing response suppression was significantly reduced after music training. There was no significant difference between pre‐ and post‐test for the visual art or the control group. The effect of music training on theta power indexing response suppression was associated with reduced functional connectivity between prefrontal, visual, and auditory regions. These results suggest that theta power indexes executive control mechanisms in older adults. Music training affects theta power and functional connectivity associated with response suppression. These findings contribute to a better understanding of inhibitory control ability in older adults and the neuroplastic effects of music interventions.

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Section: Introductionmentioning

confidence: 92%

Section: Introductionmentioning

confidence: 99%

Music training modulates theta brain oscillations associated with response suppression

Moussard

Guo

et al. 2022

Annals of the New York Academy of Sciences

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“…Instead, individuals build expectancies about upcoming events and the likelihood to engage, e.g., in inhibitory control. This establishes a proactive control state in between the inhibitory requirements/trials, which also reflects different task demands 29,38 . Intriguingly, such proactive control states are related to theta band activity 39 and, even more importantly, are predictive for the neurophysiological processes that occur while (subsequently) engaging in inhibitory control 29,38 .…”

Section: Alcohol-induced Deficits In Reactive Control Of Response Sel...mentioning

confidence: 98%

“…This establishes a proactive control state in between the inhibitory requirements/trials, which also reflects different task demands 29,38 . Intriguingly, such proactive control states are related to theta band activity 39 and, even more importantly, are predictive for the neurophysiological processes that occur while (subsequently) engaging in inhibitory control 29,38 . This shows that understanding how acute alcohol intoxication affects proactive control preceding the actual response inhibition is probably as important as understanding the directly inhibition-associated processes.…”

Section: Alcohol-induced Deficits In Reactive Control Of Response Sel...mentioning

confidence: 98%

Alcohol-induced deficits in reactive control of response selection and inhibition are counteracted by a seemingly paradox increase in proactive control

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Wendiggensen

Ghin

et al. 2023

Sci Rep

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High-dose alcohol intoxication reduces cognitive control, including inhibition. Although inhibition deficits may contribute to the behavioral deficits commonly observed in alcohol use disorder (AUD), many questions about potentially modulating factors have remained unanswered. We examined the effects of experimentally induced high-dose alcohol intoxication (~ 1.1 ‰) on the interplay between controlled vs. automatic response selection and inhibition in healthy young men. A holistic EEG-based theta activity analysis that considered both reactive control during task performance and preceding proactive control processes was run. It revealed a previously unknown seesaw relationship, with decreased reactive control, but paradoxically increased proactive control. Most importantly, alcohol-induced increases in proactive occipital theta band power were associated with reductions in negative alcohol effects on reactive control processes associated with decreased activity in the SMA and medial frontal cortex. Our findings demonstrate that research should not solely focus on immediate effects during task performance. Aside from differential neurobiochemical and neuroanatomical effects of alcohol, it is also conceivable that proactive control may have been recruited in a (secondary) response to compensate for alcohol-induced impairments in reactive control. Against this background, it could be promising to investigate changes in such compensatory mechanisms in pronounced alcohol-associated inhibition deficits, like in AUD patients.

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“…In EEG research, for example, compared to the inattentive subtype, those with the combined subtype show higher amplitude beta oscillations at electrodes over the sensorimotor cortex during a cued-flanker inhibitory task (thought to reflect weaker motor response planning (12)). They also show weaker source-localized oscillatory theta power over right frontal areas during the pre-trial intervals of a Go/No-Go task (15). However, contradictory evidence complicates this hypothesis: differences in cognitive measures of inhibitory control often fail to distinguish between subtypes, and electrophysiological research has found no differences between inattentive and hyperactive/impulsive subtypes in the event-related potentials thought to underly motor response inhibition (6,16,17,18,19).…”

Section: Introductionmentioning

confidence: 99%

Dynamic configuration of large-scale cortical networks during an inhibitory task accounts for heterogeneity in attention-deficit/hyperactivity disorder traits

Hare

Tekok-Kılıç

Marshall

et al. 2021

Preprint

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The heterogeneity of attention-deficit/hyperactivity disorder (ADHD) traits (inattention vs. hyperactivity/impulsivity) complicates diagnosis and intervention. Identifying how the configuration of large-scale functional brain networks during cognitive processing correlate with this heterogeneity could help us understand the neural mechanisms altered across ADHD presentations. Here, we recorded high-density EEG while 62 non-clinical participants (ages 18-24; 32 male) underwent an inhibitory control task (Go/No-Go). Functional EEG networks were created using sensors as nodes and across-trial phase-lag index values as edges. Using cross-validated LASSO regression, we examined whether graph-theory metrics applied to both static networks (averaged across time-windows: -500 to 0ms, 0 to500ms) and dynamic networks (temporally layered with 2ms intervals), were associated with hyperactive/impulsive and inattentive traits. Network configuration during response execution/inhibition was associated with hyperactive/impulsive (mean R2 across test sets = .20, SE = .02), but not inattentive traits. Post-stimulus results at higher frequencies (Beta, 14-29Hz; Gamma, 30-90Hz) showed the strongest association with hyperactive/impulsive traits, and predominantly reflected less burst-like integration between modules in oscillatory beta networks during execution, and increased integration/small-worldness in oscillatory gamma networks during inhibition. We interpret the beta network results as reflecting weaker integration between specialized pre-frontal and motor systems during motor response preparation, and the gamma results as reflecting a compensatory mechanism used to integrate processing between less functionally specialized networks. This research demonstrates that the neural network mechanisms underlying response execution/inhibition might be associated with hyperactive/impulsive traits, and that dynamic, task-related changes in EEG functional networks may be useful in disentangling ADHD heterogeneity.

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The dynamics of theta-related pro-active control and response inhibition processes in AD(H)D

Abstract: Highlight Theta-related pro-active control is examined in ADHD/ADD. inter-relation of pro-active control and inhibition-relation activity is modulated in AD(H)D. Dynamics between pre-trial and within-trials differs between AD(H)D subtypes.

Cited by 12 publications

References 79 publications

Music training modulates theta brain oscillations associated with response suppression

Music training modulates theta brain oscillations associated with response suppression

Alcohol-induced deficits in reactive control of response selection and inhibition are counteracted by a seemingly paradox increase in proactive control

Dynamic configuration of large-scale cortical networks during an inhibitory task accounts for heterogeneity in attention-deficit/hyperactivity disorder traits

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