The E3 ligase TRIM22 functions as a tumor suppressor in breast cancer by targeting CCS for proteasomal degradation to inhibit STAT3 signaling

Yang, Yunkai; Hao, Xinhui; Zhang, Jingyao; Gao, Tianyang; Huo, Miaomiao; Liu, Wei; Hu, Ting; Ma, Tianyu; Yuan, Baowen; Zhang, Min; Teng, Xu; Yu, Hefen; Huang, Wei; Wang, Yan

doi:10.1016/j.canlet.2024.217157

Cancer Letters

2024

DOI: 10.1016/j.canlet.2024.217157

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The E3 ligase TRIM22 functions as a tumor suppressor in breast cancer by targeting CCS for proteasomal degradation to inhibit STAT3 signaling

Yunkai Yang,

Xinhui Hao,

Jingyao Zhang

et al.

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2024

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Cited by 3 publications

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Roles of Copper Transport Systems Members in Breast Cancer

Chen,

Li,

et al. 2024

Cancer Medicine

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BackgroundThe occurrence and progression of breast cancer are closely linked to copper ion homeostasis. Both copper deficiency and excess can inhibit breast cancer growth, while copper transport systems may contribute to its progression by regulating copper ion transport and the activity of associated proteins. However, a comprehensive review of the roles and applications of copper transport systems in breast cancer remains limited. In this study, we summarize the workflow of copper transport systems and the dual role of copper in cancer, highlighting the contributions of specific members of the copper transport system to breast cancer.MethodsA comprehensive search of the PubMed database was conducted to identify articles published over the past 30 years that focus on the relationship between copper transport system members and breast cancer. The findings were synthesized to elucidate the roles and mechanisms of these transporters in the onset and progression of breast cancer.ResultsWe identified 13 members of the copper transport system associated with the occurrence, progression, and mortality of breast cancer, including SLC31A1, DMT1, ATP7A, ATP7B, MTs, GSH, ATOX1, CCS, COX17, SCO1, SCO2, and COX11. Our findings revealed that, apart from STEAP, the remaining 12 members were overexpressed in breast cancer. These members influence the onset, progression, and cell death of breast cancer by modulating biological pathways such as intracellular copper ion levels and ROS. Notably, we observed for the first time that depletion of the copper storage protein GSH leads to increased copper ion accumulation, resulting in cuproptosis in breast cancer cells.ConclusionBy integrating the members of the copper transport system in breast cancer, we offer novel insights for the treatment of breast cancer and copper‐related therapies.

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Roles of Copper Transport Systems Members in Breast Cancer

Chen,

Li,

et al. 2024

Cancer Medicine

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Multifaceted role of TRIM28 in health and disease

Maghsoudloo,

Mokhtari,

Jamali

et al. 2024

MedComm

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The TRIM (tripartite motif) family, with TRIM28 as a key member, plays a vital role in regulating health and disease. TRIM28 contains various functional domains essential for transcriptional regulation, primarily through its interaction with KRAB‐ZNF proteins, which influence chromatin remodeling and gene expression. Despite extensive research, the precise mechanisms by which TRIM28 impacts health and disease remain elusive. This review delves into TRIM28’s multifaceted roles in maintaining health, contributing to a variety of diseases, and influencing cancer progression. In cancers, TRIM28 exhibits a dual nature, functioning as both a tumor promoter and suppressor depending on the cellular context and cancer type. The review also explores its critical involvement in processes such as DNA repair, cell cycle regulation, epithelial‐to‐mesenchymal transition, and the maintenance of stem cell properties. By uncovering TRIM28’s complex roles across different cancers and other diseases, this review underscores its potential as a therapeutic target. The significance of TRIM28 as a versatile regulator opens the door to innovative therapeutic strategies, particularly in cancer treatment and the management of other diseases. Ongoing research into TRIM28 may yield key insights into disease progression and novel treatment options.

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Diagnostic value of TRIM22 in diabetic kidney disease and its mechanism

Wang,

Ge,

Wang

et al. 2024

Endocrine

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The E3 ligase TRIM22 functions as a tumor suppressor in breast cancer by targeting CCS for proteasomal degradation to inhibit STAT3 signaling

Cited by 3 publications

References 47 publications

Roles of Copper Transport Systems Members in Breast Cancer

Roles of Copper Transport Systems Members in Breast Cancer

Multifaceted role of TRIM28 in health and disease

Diagnostic value of TRIM22 in diabetic kidney disease and its mechanism

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