The early embryological development of the fetal and permanent adrenal cortex in man

Uotila, U.

doi:10.1002/ar.1090760207

Cited by 57 publications

(23 citation statements)

References 4 publications

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“…Morphological studies have led to three different models. First, the adult zone may derive from the coelomic epithelia after cells that form the fetal zone have migrated (33); alternatively, the fetal and adult zones may derive simultaneously from discrete populations of coelomic epithelial cells (3). Both of these models postulate that the cells comprising the fetal and adult zones are already determined in their cell fates when they develop from the coelomic epithelia.…”

Section: Establishment Of Adrenal and Gonadal Primordial Cellsmentioning

confidence: 99%

Developmental Links between the Fetal and Adult Zones of the Adrenal Cortex Revealed by Lineage Tracing

Zubair

Parker

Morohashi

2008

Molecular and Cellular Biology

100

101

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The nuclear receptor Ad4BP/SF-1 is essential for development of the adrenal cortex and the gonads, which derive from a common adrenogonadal primordium. The adrenal cortex subsequently forms morphologically distinct compartments: the inner (fetal) and outer (definitive or adult) zones. Despite considerable effort, the mechanisms that mediate the differential development of the adrenal and gonadal primordia and the fetal and adult adrenal cortices remain incompletely understood. We previously identified a fetal adrenal-specific enhancer (FAdE) in the Ad4BP/SF-1 locus that directs transgene expression to the fetal adrenal cortex and demonstrated that this enhancer is autoregulated by Ad4BP/SF-1. We now combine the FAdE with the Cre/loxP system to trace cell lineages in which the FAdE was active at some stage in development. These lineage-tracing studies establish definitively that the adult cortex derives from precursor cells in the fetal cortex in which the FAdE was activated before the organization into two distinct zones. The potential of these fetal adrenocortical cells to enter the pathway that eventuates in cells of the adult cortex disappeared by embryonic day 14.5. Thus, these studies demonstrate a direct link between the fetal and adult cortices involving a transition that must occur before a specific stage of development.

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Section: Establishment Of Adrenal and Gonadal Primordial Cellsmentioning

confidence: 99%

Developmental Links between the Fetal and Adult Zones of the Adrenal Cortex Revealed by Lineage Tracing

Zubair

Parker

Morohashi

2008

Molecular and Cellular Biology

100

101

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“…These studies speculated that the adrenal cortex originates from the dorsal coelomic epithelia lying between the dorsal mesentery and the developing urogenital ridge (Pankratz 1931;Uotila 1940), the underlying mesenchymal cells (Roos 1966), or both the epithelial and the mesenchymal cells (Gruenwald 1942a). The cell populations in similar regions were also presumed to be the blastemas for the gonads (Whitehead 1904;Fischel 1930;Gruenwald 1942a,b;Torry 1945;Zamboni & Upandhyay 1982;Satoh 1985;Byskov 1986).…”

Section: From the Adreno-genital Primordium To Mature Steroidogenic Tmentioning

confidence: 99%

The ontogenesis of the steroidogenic tissues

Morohashi

1997

Genes to Cells

105

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Based on the common function of steroid hormone-producing tissues and homologous regulation by the hypothalamo-pituitary axis, the adrenal cortex and the gonads have been suggested to have an intimate ontogenic relationship. This assumption is also supported by the findings of common transcription factors implicated in the differentiation of both types of tissue and further supported by concomitant defects in such tissues due to the disruption of a single gene. Similarly, simultaneous anomalies in those tissues are also observed in some diseases caused by mutations of the genes encoding those transcription factors. A recent immunohistochemical study with one of the transcription factors, Ad4BP/SF-1, definitely demonstrated the presence of a particular cell population designated the 'adreno-genital primordium (AGP)' which gives rise to both the adrenal cortex and the gonads. In the process of differentiation from the AGP to the mature adrenal cortex and the gonads of the two sexes, several interesting issues can be raised as to the next targets for the study. To address these issues it is important to elucidate the upstream regulatory mechanisms and downstream target genes of such transcription factors as WT1, SRY, SOX9 and DAX1, in addition to Ad4BP/SF-1, all of which are implicated in steroidogenic tissue differentiation.

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“…The original observations of the Polish students were confirmed in 1911 by Elliot and Armour [30]. Out of the earlier reports on the subject, publications of Keene and Hewer [31], Tobeck [32], Uotila [33], Swinyard [17], Velican [34], [35], Lantan [36,37] and Wo³ynska [38] should be mentioned. All of them provided detailed cytological descriptions of developing adrenal gland.…”

Section: Morphological Aspects Of Human Adrenal Gland Developmentmentioning

confidence: 96%

100th anniversary of the discovery of the human adrenal fetal zone by Stella Starkel and Lesław Węgrzynowski: how far have we come?

Malendowicz

2011

Folia Histochem Cytobiol.

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The early embryological development of the fetal and permanent adrenal cortex in man

Abstract: This paper preseiits observations on the development of the huinaii adrenal cortex from its iiiceptioii until the embryo has grow11 to a leiigtli of 20 mni. Special attention has been given to the genesis of the permanent (true) cortex and its relationship to the fetal cortex.

Cited by 57 publications

References 4 publications

Developmental Links between the Fetal and Adult Zones of the Adrenal Cortex Revealed by Lineage Tracing

Developmental Links between the Fetal and Adult Zones of the Adrenal Cortex Revealed by Lineage Tracing

The ontogenesis of the steroidogenic tissues

100th anniversary of the discovery of the human adrenal fetal zone by Stella Starkel and Lesław Węgrzynowski: how far have we come?

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