The early history of sialic acids

Faillard, Hans

doi:10.1016/0968-0004(89)90034-0

Cited by 25 publications

(11 citation statements)

References 22 publications

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“…Given that NAs from different species share the same substrates (e.g. glycoproteins, glycolipids, and oligosaccharides) (48), exogenous NAs derived from few microorganisms (mostly of bacterial origin) have been used to deduce the role played by NAs with respect to the life cycle of HIV-1. Interestingly, several bacteria and viruses produce NA as virulence factors either on their surface or in a secreted form (19).…”

Section: Discussionmentioning

confidence: 99%

Syncytium Formation and HIV-1 Replication Are Both Accentuated by Purified Influenza and Virus-associated Neuraminidase

Sun¹,

Barbeau²,

Sato³

et al. 2002

Journal of Biological Chemistry

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Section: Discussionmentioning

confidence: 99%

Syncytium Formation and HIV-1 Replication Are Both Accentuated by Purified Influenza and Virus-associated Neuraminidase

Sun¹,

Barbeau²,

Sato³

et al. 2002

Journal of Biological Chemistry

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“…Gottschalk (55) was the first to propose a coherent structure of Neu5Ac and also provided a survey of the early history of sialobiology, as the field has since come to be known (110). The excellent short review by Hans Faillard on the early history of sialic acid research also is highly recommended (46). Any of the more recent monographs or review articles by Roland Schauer and his colleagues should be consulted for the methodological details for working with sialic acids (e.g., [118][119][120].…”

Section: Introductionmentioning

confidence: 99%

Diversity of Microbial Sialic Acid Metabolism

Vimr

Kalivoda

Deszo

et al. 2004

Microbiol Mol Biol Rev

516

663

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Sialic acids are structurally unique nine-carbon keto sugars occupying the interface between the host and commensal or pathogenic microorganisms. An important function of host sialic acid is to regulate innate immunity, and microbes have evolved various strategies for subverting this process by decorating their surfaces with sialylated oligosaccharides that mimic those of the host. These subversive strategies include a de novo synthetic pathway and at least two truncated pathways that depend on scavenging host-derived intermediates. A fourth strategy involves modification of sialidases so that instead of transferring sialic acid to water (hydrolysis), a second active site is created for binding alternative acceptors. Sialic acids also are excellent sources of carbon, nitrogen, energy, and precursors of cell wall biosynthesis. The catabolic strategies for exploiting host sialic acids as nutritional sources are as diverse as the biosynthetic mechanisms, including examples of horizontal gene transfer and multiple transport systems. Finally, as compounds coating the surfaces of virtually every vertebrate cell, sialic acids provide information about the host environment that, at least in Escherichia coli, is interpreted by the global regulator encoded by nanR. In addition to regulating the catabolism of sialic acids through the nan operon, NanR controls at least two other operons of unknown function and appears to participate in the regulation of type 1 fimbrial phase variation. Sialic acid is, therefore, a host molecule to be copied (molecular mimicry), eaten (nutrition), and interpreted (cell signaling) by diverse metabolic machinery in all major groups of mammalian pathogens and commensals

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“…There was once an argument that N-glycolylneuraminic acid (Neu5Gc) is cancer-specific carbohydrate in humans [14][15][16]. This argument remains to be perfected because there is NeuGc in many other animals and species.…”

Section: Diagnostic Investigation and Clinical Applicationsmentioning

confidence: 99%

“…They play critical roles in many physiological and pathologic processes, including inter-molecular binding that leads to microbial infections, regulation of the immune response, the progression/spread of human malignancies and in certain aspects of human evolution [14][15][16]. The earliest work tackling the close relationships between sias and tumors was traced back to Kimura et al from 1958 [17][18].…”

Section: Historic Review and Biomedical Information Gains In This Topicmentioning

confidence: 99%

Antimetastatic therapy at aberrant sialylation in cancer cells, a potential hotspot

Lu¹,

Lu²,

Xu³

et al. 2017

Clin Proteom Bioinform

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Neoplasm metastases involve a fixed cascade of pathological processes responsible for 90% cancer mortality worldwide. However, currently neoplasm metastases are poorly managed in humans for lack of good drug targets. To change this situation, new drug targets must be established. Aberrantly tumor sialylated study is one of potential drug targets, which has been involved for a half century. Many new discoveries show promising outcomes in experimental models. Since neoplasm tissues often contain higher levels of total sialic acids (sia), sialic acids-containing antigens, several types of sialic acid analogue, such as N-glycolylneuraminic acids, growing attentions of sia-related tumor diagnostics and therapeutics are needed to work with new cancer treatment approaches. Previously some compounds that inhibit pathologic pathways of sialic acids in tumor movements in vitro and tumor metastasis in animal tumor models were found. This type of pharmacological limitations of cancer metastasis treatments can be possibly solved by future glycome/metabolomics technology utilities. As the "central dogma" of glycobiology is still unknown to us, some fundamental questions related to carbohydrate itself are even more important comparing with individual experimental discoveries. In addition, mathematicor physics-majored talents in this topic might catalyze these new discoveries. In this review, we document these strings of lab biologic evidence, drug development updating and close relationships between cancer pathological profiles and therapeutic targets/benefits in clinics.

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The early history of sialic acids

Cited by 25 publications

References 22 publications

Syncytium Formation and HIV-1 Replication Are Both Accentuated by Purified Influenza and Virus-associated Neuraminidase

Syncytium Formation and HIV-1 Replication Are Both Accentuated by Purified Influenza and Virus-associated Neuraminidase

Diversity of Microbial Sialic Acid Metabolism

Antimetastatic therapy at aberrant sialylation in cancer cells, a potential hotspot

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