The early immune response to Mycobacterium lepraemurium in inbred mice and rats

Waksman, Byron H.

doi:10.1016/0090-1229(73)90039-1

Cited by 9 publications

(5 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Our data are in agreement with other investigators in this regard [10,24,26,41]. In the freeze-thaw killed challenged group, the decay of positive skin reactivity to the homologous cell extract antigen represents in all probability a progressive dimunition of antigenic stimulus.…”

Section: Discussionsupporting

confidence: 83%

“…To date, however, it has not been possible to identify specific ge netic factors that may predispose an individ ual to become lepromatous, either by stud ies of the disease in monozygotic twins [4], or by preliminary analysis of HLA pheno typic frequencies among patients with lepro sy [4,16]. Outbred mice have been shown to vary markedly in their response in a rath er uniform manner [11,41], Furthermore, significant differences have been observed between various inbred strains of mice [12,24,25]. It is not clear whether the develop ment of the immunodeficient state in lepro matous type of leprosy, be it human or mu rine, is a cause or an effect of the infection.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Studies on Immune Response to <i>Mycobacterium lepraemurium</i>

Navalkar¹,

Patel²,

Kanchana³

1980

Int Arch Allergy Immunol

View full text Add to dashboard Cite

Evaluation of the cell-mediated immune response (CMI) in mice infected with Mycobacterium lepraemurium revealed a disturbance in the nonspecific components of the CMI. Expression of delayed type hypersensitivity (DTH) in skin test studies indicated that the organism is capable of inducing skin reactivity in mice. This begins at a very early stage of infection and subsequently decays as the infection becomes disseminated. At this stage, gross pathological changes are noticed followed by a high rate of mortality. An in vitro correlate of DTH, namely lymphocyte transformation, was in concordance with the observation on DTH. The suppression of CMI appears to be due to extensive multiplication of the infecting pathogen within the host system.

show abstract

Section: Discussionsupporting

confidence: 83%

Section: Introductionmentioning

confidence: 99%

Studies on Immune Response to <i>Mycobacterium lepraemurium</i>

Navalkar¹,

Patel²,

Kanchana³

1980

Int Arch Allergy Immunol

View full text Add to dashboard Cite

show abstract

“…In the animal model the development of cellmediated immune reactions after infection with mycobacteria is determined by genetic factors of the host (11,48) and by the amount and route of administration of the antigen (3, 10, 38). Moreover, viable mycobacteria show more profound effects than do killed mycobacteria (3,10).…”

Section: Discussionmentioning

confidence: 99%

Lymphocyte transformation test in leprosy: decreased lymphocyte reactivity to Mycobacterium leprae in lepromatous leprosy, with no evidence for a generalized impairment

Faber¹,

Leiker²,

Nengerman³

et al. 1978

Infect Immun

View full text Add to dashboard Cite

Untreated leprosy patients were examined with respect to lymphocyte transformation in vitro after stimulation with mycobacterial and other microbial antigens, allogeneic lymphocytes, or nonspecific mitogens. Methods were used to circumvent technical variability. The results were compared with those obtained in controls matched for age, sex, race, and environment. No evidence was found for a generalized impairment of lymphocyte transformation in vitro, whereas a specific defect towards Mycobacterium leprae was demonstrable in lepromatous leprosy patients. The response to M. leprae, investigated in untreated and treated leprosy patients, decreased along the leprosy spectrum. Moreover, the results of the one-way mixed lymphocyte cultures showed that lymphocytes from leprosy patients had a normal stimulator and responder capacity, when they were tested against a panel of allogeneic lymphocytes. The influence of serum factors was investigated in untreated leprosy patients in the mixed lymphocyte culture. On average, tuberculoid as well as lepromatous sera showed a low-level depressive effect, but some sera showed a stimulatory effect. Therefore, a depressive effect of serum factors cannot be considered to be a general feature of leprosy. The correlation between the Mitsuda type of lepromin skin test and the lymphocyte reactivity in vitro to M. leprae was studied, and a positive correlation was found.

show abstract

“…In contrast to the standard immunodiffusion by Ouchterlony techniques, CIE with intermediate gel also permits detation of nonprecipitating antibodies (1). It was recently found that three anti-MLM precipitins fretjuently were present in mice after several months of infection (19).…”

Section: Dlscussionmentioning

confidence: 99%

“…The role of circulating antiliodies in infections caused by intracellular parasites is not clear (21). Both active and passive induction of antibodies against MLM in C57BL mice has been shown to cause a temporary depression of the delayed hypersensitivity reaction induced by a challenge dose of MLM (19). It has recently been shown that (^57BL mice may lose their delayed-type hypersensltivit)' to MLM during a heavy, disseminated MLM infection (4).…”

Section: Dlscussionmentioning

confidence: 99%

Experimental Murine Leprosy

Closs

Kronvall

1975

Scand J Immunol

View full text Add to dashboard Cite

Sera from C3H and C57BL mice infected with Mycobacterium lepraemurium (MLM) and from human leprosy patients were examined for antibodies against MLM by a crossed immunoelectrophoresis (CIE) technique. Altogether antibodies against six or seven MLM antigens were found in the mouse sera. After a small inoculum of MLM, C3H mice produced more antibodies than C57BL mice. After a large inoculum both strains produced about the same amount of antibodies but showed qualitative differences in their response patterns. A serum pool from patients with lepromatous leprosy contained antibodies against six MLM antigens; five of these were identical with the antigens against which antibodies were found in infected mice. C57BL mice that had lost their delayed-type hypersensitivity to MLM during the course of a disseminated infection showed a fairly strong antibody response to three antigens and a weak response to three others. Since almost the same spectrum of antibodies, although in lower titres, could be demonstrated in C57BL mice with intact delayed-type hypersensitivity to the bacilli, these antibodies did not seem to interfere with the expression of cell-mediated immunity.

show abstract

The early immune response to Mycobacterium lepraemurium in inbred mice and rats

Cited by 9 publications

References 18 publications

Studies on Immune Response to <i>Mycobacterium lepraemurium</i>

Studies on Immune Response to <i>Mycobacterium lepraemurium</i>

Lymphocyte transformation test in leprosy: decreased lymphocyte reactivity to Mycobacterium leprae in lepromatous leprosy, with no evidence for a generalized impairment

Experimental Murine Leprosy

Contact Info

Product

Resources

About