2015
DOI: 10.1096/fj.14-255976
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The early origins of food preferences: targeting the critical windows of development

Abstract: The nutritional environment to which an individual is exposed during the perinatal period plays a crucial role in determining his or her future metabolic health outcomes. Studies in rodent models have demonstrated that excess maternal intake of high-fat and/or high-sugar "junk foods" during pregnancy and lactation can alter the development of the central reward pathway, particularly the opioid and dopamine systems, and program an increased preference for junk foods in the offspring. More recently, there have b… Show more

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Cited by 40 publications
(30 citation statements)
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“…Mice were fed a ketogenic or control diet during the juvenile period (PND 21-60). The rationale for the timing of the diet intervention is that the juvenile developmental window represents a period of brain reorganization and maturation influenced by dietary events [64,65].…”
Section: Discussionmentioning
confidence: 99%
“…Mice were fed a ketogenic or control diet during the juvenile period (PND 21-60). The rationale for the timing of the diet intervention is that the juvenile developmental window represents a period of brain reorganization and maturation influenced by dietary events [64,65].…”
Section: Discussionmentioning
confidence: 99%
“…Rodents have been used as a model for the analysis of multiple brain circuits, including the mesolimbic dopaminergic system, strongly related to food choices. In these animals, dopamine receptors can be detected in the mesolimbic system at the beginning of embryonic life, being vulnerable to environmental stresses, as the nutrition, in this period (Gugusheff et al, 2015).…”
Section: Study Of Food Preferencementioning
confidence: 99%
“…This may be due to an increased preference for these macronutrients (Vucetic et al, 2010) but is not associated with altered orosensory stimulation by their taste (Treesukosol et al, 2014). Whilst food preferences can be programmed by maternal nutrition (reviewed in (Gugusheff et al, 2014)), maternal obesity is also associated with altered motivation for palatable foods in multiple rodent models (Grissom et al, 2014b;Naef et al, 2011;Rodriguez et al, 2012). The programmed increases in preference for fat and sugar and altered motivation to work for such foods are associated with changes in dopaminergic tone (Naef et al, 2011(Naef et al, , 2013 as well as in expression of key dopaminergic and opioidergic signalling genes (Naef et al, 2011;Ong and Muhlhausler, 2011;Vucetic et al, 2010), with evidence for epigenetic regulation at some loci (Grissom et al, 2014a;Vucetic et al, 2010).…”
Section: Central Control Of Food Intake: Programming the Hypothalamusmentioning
confidence: 99%