The early phase of tissue invasion byTrichuris muris (Nematoda: Trichuroidea)

Panesar, Tarlochan S.

doi:10.1007/bf00925723

Cited by 14 publications

(12 citation statements)

References 16 publications

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“…This result accords with the majority of the previous studies of nematode infection in rodents, and implies that innate resistance is either absent or is unmodified by nutritional status (Bolin et al 1977;Brailsford & Mapes, 1987;Slater, 1987). This also suggests that gut physiology and structure, which are important triggers for T. muris establishment (Panesar & Croll, 1980;Panesar, 1981) and which may be modified by protein deficiency (Alleyne et al 1977), were relatively unaffected by the dietary regimes used in the present study. T. muris establishment rate, however, was dependent on infection dose, declining significantly at the high dose.…”

Section: Discussionmentioning

confidence: 60%

The effect of the protein content of CBA/Ca mouse diet on the population dynamics of Trichuris muris (Nematoda) in primary infection

Michael

Bundy

1991

Parasitology

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The relationship between host dietary protein and intestinal helminth population biology during primary infection was studied using a mouse-T. muris experimental model. Uninfected CBA/Ca mice fed either a 4% (by mass) or 16% protein diet grew at a similar rate, but both suffered significant growth retardation when infected with T. muris. T. muris initial establishment and fecundity were unaffected by dietary protein content, but were significantly influenced by infection dose, declining at the higher level of infection. Dietary protein deficiency increased parasite survival at high infection levels. Heavily infected hosts fed the 16% protein diet were found to expel almost the whole of their infections around day 21 p.i. By contrast, this response appeared defective in hosts fed the lower 4% protein diet, resulting in the establishment and survival of large, chronic and patent infections. Mean faecal egg output per mouse increased with infection dose in animals fed a low protein diet, but was low and unrelated to infection exposure in hosts fed the 16% protein diet. It is concluded that low protein levels in diet, via alterations in host resistance, may have an important influence on the transmission of T. muris.

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Section: Discussionmentioning

confidence: 60%

The effect of the protein content of CBA/Ca mouse diet on the population dynamics of Trichuris muris (Nematoda) in primary infection

Michael

Bundy

1991

Parasitology

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“…However, expression levels of the other two genes were low at both day 19 and day 60. The intestinal epithelial cell forms the host-parasite interface and represents the niche within which Trichuris parasites burrow (37). We present data showing that epithelial cells from BALB/c mice represent one cellular source of intelectin within the gut.…”

Section: Discussionmentioning

confidence: 83%

Identification of Novel Genes in Intestinal Tissue That Are Regulated after Infection with an Intestinal Nematode Parasite

et al. 2005

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“…Trichuris is essentially a tissue parasite; after invasion of host intestinal mucosa by infective L, 1 larvae, the anterior portion of the adult worm becomes embedded within a syncytial tunnel derived from host caecal epithelium (Panesar, 1981). This anterior region contains a row of stichocytes which duct into the oesophagus.…”

Section: Introductionmentioning

confidence: 99%

Characterization of peptidases of adultTrichuris muris

et al. 1994

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Excretory/secretory (E/S) material of Trichuris muris was found to contain 2 major peptidases, M(r) 85 and 105 kDa, which degrade gelatin optimally at pH 6.0 in sodium dodecyl sulphate-polyacrylamide gels. The peptidases were inactivated by diisopropylfluorophosphate, leupeptin and soybean trypsin inhibitor, but were unaffected by inhibitors of aspartic-, cysteine- and metallo-peptidases, indicating that they are serine peptidases. Both enzymes were detectable within 5 h after incubation of worms in culture medium and showed a time-dependent increase in levels. Neither peptidase was detected in worm extracts, suggesting that they are activated during or following secretion from worms. Live worms degraded a radio-isotope labelled extracellular matrix protein substratum derived from mammalian cells. Aminopeptidase activities capable of catalysing hydrolysis of amino acyl aminomethylcoumarin (MCA) substrates and a Z-Phe-Arg-MCA-hydrolysing cysteine peptidase activity, were detected in extracts of adult worms but not in E/S material.

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The early phase of tissue invasion byTrichuris muris (Nematoda: Trichuroidea)

Cited by 14 publications

References 16 publications

The effect of the protein content of CBA/Ca mouse diet on the population dynamics of Trichuris muris (Nematoda) in primary infection

The effect of the protein content of CBA/Ca mouse diet on the population dynamics of Trichuris muris (Nematoda) in primary infection

Identification of Novel Genes in Intestinal Tissue That Are Regulated after Infection with an Intestinal Nematode Parasite

Characterization of peptidases of adultTrichuris muris

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