The East Flanders Prospective Twin Survey (EFPTS): An Actual Perception

Derom, Cathérine; Thiery, Evert; Peeters, Hilde; Vlietinck, Robert; Defoort, Paul; Frijns, Jean-Pierre

doi:10.1017/thg.2012.75

Cited by 36 publications

(29 citation statements)

References 44 publications

(79 reference statements)

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“…The East Flanders Prospective Twin Study (EFPTS), a population based register of multiple births in the province of East-Flanders (Belgium), started in 1964 to enrol twins at birth [11]. The twin cohort in our analysis was based on a previously designed twin study containing 424 twin pairs [12].…”

Section: Methodsmentioning

confidence: 99%

Blood pressure in young adulthood and residential greenness in the early-life environment of twins

et al. 2017

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BackgroundPrevious research shows that, besides risk factors in adult life, the early-life environment can influence blood pressure and hypertension in adults. However, the effects of residential traffic exposure and residential greenness in the early-life on blood pressure in young adulthood are currently unknown.MethodsAmbulatory (24-h) blood pressures of 278 twins (132 pairs) of the East Flanders Prospective Twins Study were obtained at the age of 18 to 25 years. Prenatal and adulthood residential addresses were geocoded and used to assign prenatal and postnatal traffic and greenness indicators. Mixed modelling was performed to investigate blood pressure in association with greenness while adjusting for potential confounding factors.ResultsNight-time systolic blood pressure was inversely associated with greenness at the residential address in twins living at the same address their entire life (non-movers, n = 97, 34.9%). An interquartile increase in residential greenness exposure (1000 m radius) was associated with a 3.59 mmHg (95% CI: -6.0 to −1.23; p = 0.005) lower adult night systolic blood pressure. Among twins who were living at a different address than their birth address at time of the measurement (n = 181, 65.1%), night-time blood pressure was inversely associated with residential surrounding greenness at adult age as well as with residential greenness in early-life. However after additional adjustment for residential greenness exposure in adulthood, only residential greenness exposure in early-life was significantly associated with night systolic blood pressure. While no significant effect of adult residential greenness with adult blood pressure was observed, while accounting for the early-life greenness exposure.ConclusionsLower residential greenness in the early-life environment was independently associated with a higher adult blood pressure. This indicates that residential greenness has persistent effects on blood pressure.Electronic supplementary materialThe online version of this article (doi:10.1186/s12940-017-0266-9) contains supplementary material, which is available to authorized users.

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Section: Methodsmentioning

confidence: 99%

Blood pressure in young adulthood and residential greenness in the early-life environment of twins

et al. 2017

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“…[18] All families with twins reaching the age of 10 years had been contacted by letter and had been further informed by telephone calls or home visits. The response rate was approximately 40%.…”

Section: Methodsmentioning

confidence: 99%

Genetic, Maternal and Placental Factors in the Association between Birth Weight and Physical Fitness: A Longitudinal Twin Study

et al. 2013

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BackgroundAdult cardiorespiratory fitness and muscle strength are related to all-cause and cardiovascular mortality. Both are possibly related to birth weight, but it is unclear what the importance is of genetic, maternal and placental factors in these associations.DesignPeak oxygen uptake and measures of strength, flexibility and balance were obtained yearly during adolescence (10–18 years) in 114 twin pairs in the Leuven Longitudinal Twin Study. Their birth weights had been collected prospectively within the East Flanders Prospective Twin Survey.ResultsWe identified linear associations between birth weight and adolescent vertical jump (b = 1.96 cm per kg birth weight, P = 0.02), arm pull (b = 1.85 kg per kg birth weight P = 0.03) and flamingo balance (b = −1.82 attempts to stand one minute per kg birth weight, P = 0.03). Maximum oxygen uptake appeared to have a U-shaped association with birth weight (the smallest and largest children had the lowest uptake, P = 0.01), but this association was no longer significant after adjustment for parental BMI. Using the individual twin’s deviation from his own twin pair’s average birth weight, we found positive associations between birth weight and adolescent vertical jump (b = 3.49, P = 0.0007) and arm pull (b = 3.44, P = 0.02). Δ scores were calculated within the twin pairs as first born twin minus second born twin. Δ birth weight was associated with Δ vertical jump within MZ twin pairs only (b = 2.63, P = 0.009), which indicates importance of placental factors.ConclusionsWe found evidence for an association between adolescent physical performance (strength, balance and possibly peak oxygen uptake) and birth weight. The associations with vertical jump and arm pull were likely based on individual, more specifically placental (in the case of vertical jump) factors. Our results should be viewed as hypothesis-generating and need confirmation, but potentially support preventive strategies to optimize birth weight, for example via placental function, to target later fitness and health.

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“…Data came from the TWINSSCAN cohort [20], which comprises a subsample of 839 adolescents from the East Flanders Prospective Twin Study (EFPTS), a register of all multiple births in the Province of East Flanders, Belgium from 1964 [21,22]. All twins from the registry between ages of 15 and 18 were invited to participate in the TWINSSCAN study.…”

Section: Sample and Designmentioning

confidence: 99%

Measuring resilience prospectively as the speed of affect recovery in daily life: a complex systems perspective on mental health

Kuranova

Booij

Menne-Lothmann

et al. 2020

BMC Med

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Introduction: There is growing evidence that mental disorders behave like complex dynamic systems. Complex dynamic systems theory states that a slower recovery from small perturbations indicates a loss of resilience of a system. This study is the first to test whether the speed of recovery of affect states from small daily life perturbations predicts changes in psychopathological symptoms over 1 year in a group of adolescents at increased risk for mental disorders.Methods: We used data from 157 adolescents from the TWINSSCAN study. Course of psychopathology was operationalized as the 1-year change in the Symptom Checklist-90 sum score. Two groups were defined: one with stable and one with increasing symptom levels. Time-series data on momentary daily affect and daily unpleasant events were collected 10 times a day for 6 days at baseline. We modeled the time-lagged effect of daily unpleasant events on negative and positive affect after each unpleasant event experienced, to examine at which time point the impact of the events is no longer detectable.Results: There was a significant difference between groups in the effect of unpleasant events on negative affect 90 min after the events were reported. Stratified by group, in the Increase group, the effect of unpleasant events on both negative (B = 0.05, p < 0.01) and positive affect (B = − 0. 08, p < 0.01) was still detectable 90 min after the events, whereas in the Stable group this was not the case. Conclusion: Findings cautiously suggest that adolescents who develop more symptoms in the following year may display a slower affect recovery from daily perturbations at baseline. This supports the notion that mental health may behave according to the laws of a complex dynamic system. Future research needs to examine whether these dynamic indicators of system resilience may prove valuable for personalized risk assessment in this field.

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The East Flanders Prospective Twin Survey (EFPTS): An Actual Perception

Cited by 36 publications

References 44 publications

Blood pressure in young adulthood and residential greenness in the early-life environment of twins

Blood pressure in young adulthood and residential greenness in the early-life environment of twins

Genetic, Maternal and Placental Factors in the Association between Birth Weight and Physical Fitness: A Longitudinal Twin Study

Measuring resilience prospectively as the speed of affect recovery in daily life: a complex systems perspective on mental health

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