The West Antarctic Ice Sheet (WAIS) is largely marine based and thus highly sensitive to both climatic and oceanographic changes. Therefore, the WAIS has likely had a very dynamic history over the last several million years. A complete collapse of the WAIS would result in a global sea level rise of 3.3-4.3 m, yet the world's scientific community is not able to predict its future behavior. Moreover, knowledge about past behavior of the WAIS is poor, in particular during geological times with climatic conditions similar to those expected for the near and distant future. Reconstructions and quantifications of partial or complete WAIS collapses in the past are urgently needed for constraining and testing ice sheet models that aim to predict future WAIS behavior and the potential contribution of the WAIS to global sea level rise. Large uncertainties exist regarding the chronology, extent, rates, and spatial and temporal variability of past advances and retreats of the WAIS across the continental shelves. These uncertainties largely result from the fundamental lack of data from drill cores recovered proximal to the WAIS. The continental shelf and rise of the Amundsen Sea are prime targets for drilling because the records are expected to yield archives of pure WAIS dynamics unaffected by other ice sheets and the WAIS sector draining into the Amundsen Sea Embayment (ASE) currently experiences the largest ice loss in Antarctica (Paolo et al., 2015).We propose a series of drill sites for the ASE shelf where seismic data reveal seaward-dipping sedimentary sequences that span from the preglacial depositional phase to the most recent glacial periods. Our strategy is to drill a transect from the oldest sequences close to the bedrock/basin boundary at the middle-inner shelf transition to the youngest sequences on the outer shelf in the eastern ASE. If the eastern ASE is inaccessible due to sea ice cover, a similar transect of sites can be drilled on the western ASE. The core transect will provide a detailed history of the glacial cycles in the Amundsen Sea region and allow comparison to the glacial history from the Ross Sea sector. In addition, deep-water sites on the continental rise of the Amundsen Sea are selected for recovering continuous records of glacially transported sediments and detailed archives of climatic and oceanographic changes throughout glacial-interglacial cycles. We will apply a broad suite of analytical techniques, including multiproxy analyses, to address our objectives of reconstructing the onset of glaciation in the greenhouse to icehouse transition, processes of dynamic ice sheet behavior during the Neogene and Quaternary, and ocean conditions associated with the glacial cycles.The five principal objectives of Expedition 379 are as follows:1. To reconstruct the glacial history of West Antarctica from the Paleogene to recent times and the dynamic behavior of the WAIS during the Neogene and Quaternary, especially possible partial or full WAIS collapses, and the WAIS contribution to past sea level...