The EasyPET: A novel concept for an educational cost-effective positron emission 2D scanner

Arosio, V.; Caccia, M.; Castro, I.F.; Correia, P.M.M.; Mattone, C.; Moutinho, L.M.; Santoro, R.; Silva, Ana Luísa; Veloso, J.F.C.A.

doi:10.1109/nssmic.2016.8069360

Cited by 2 publications

(4 citation statements)

References 12 publications

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“…Some interesting applications can be mentioned for the compounds studied here. It is worth considering a kinetic assessment of the new alkoxy-BODIPYs compared to their counterparts with 19 F in the boron centre, as radiolabelling BODIPYs 3 and 6 might enhance their cellular uptake, rendering them suitable for animal studies using EasyPET technology [31]. BODIPY 3 exhibits characteristics for dual-mode imaging, which could open the door for PET/fluorescence-based in vivo investigations.…”

Section: Discussionmentioning

confidence: 99%

Synthesis and In Vitro Biocompatibility Studies of Novel Alkoxy 4,4-Difluoro-4-bora-3a,4a-diaza-s-indacenes

Santos,

Araújo,

Carmo

et al. 2023

Materials

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BODIPYs are bicyclic aromatic compounds with unique spectroscopic, photophysical, and chemical properties. This study aimed to find BODIPYs with characteristics biocompatible with human cell lines for possible use as imaging agents. Six BODIPY derivatives were synthesised with groups linked to boron, fluorine, phenol, or catechol, resulting in compounds with different physicochemical characteristics. NMR, absorption, and emission spectroscopy and mass spectrometry were subsequently used to characterise them. Afterwards, the biocompatibility of these compounds was evaluated using MTT, SRB, and cellular uptake assays in A549 and H1299 cell lines. Furthermore, a haemolysis assay was performed on human blood cells. To summarise the main results, BODIPYs 1 to 4 showed considerable fluorescence. In contrast, BODIPYs 5 and 6 showed very weak fluorescence, which could be related to the presence of the catechol group and its quenching properties. Regarding biocompatibility, all compounds had metabolic activity and viability above 80% and 70%, respectively. BODIPYs 3 and 6 presented the most consistent data, demonstrating good uptake and, in general, haemolytic activity below 25%. In conclusion, the cytotoxic effects of the compounds were not considerable, and the presence of cyclic alkoxides in BODIPYs 3 and 6 may introduce exciting features that should be highlighted for dual imaging for BODIPY 3 due to its fluorescence or for radioactive labelling in the case of both BODIPYs.

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Section: Discussionmentioning

confidence: 99%

Synthesis and In Vitro Biocompatibility Studies of Novel Alkoxy 4,4-Difluoro-4-bora-3a,4a-diaza-s-indacenes

Santos,

Araújo,

Carmo

et al. 2023

Materials

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“…Each time a coincidence is detected between the two scintillation detectors, the line-of-response (LOR) considered for the two annihilation photons trajectory is the line between the two front faces of the scintillation detectors. In this configurations, the parallax effect is avoided [4,5]. The reason is that photons always penetrate the scintillation detectors perpendicularly to the front face, avoiding the uncertainty in the LOR determination.…”

Section: Introductionmentioning

confidence: 99%

“…Included in this exotic geometries of PET scanners is the EasyPET system developed at the University of Aveiro. This PET system is based in an innovative method in which two detecting cells rotate according two axes, performing a full 2D scan [4,5] similar to the one obtained with a ring based PET scanner.A scheme of the EasyPET working system is depicted in figure 1 and figure 2. The acquistion method was patented by the University of Aveiro [6] and the technology was licensed to CAEN S.p.A., being now a commercial product, part of the CAEN educational catalog [7].…”

Section: Introductionmentioning

confidence: 99%

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An EDUGATE simulation toolkit based on the educational easyPET

Correia¹,

Menoita²,

Silva³

et al. 2019

Biomed. Phys. Eng. Express

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EasyPET is a new concept of a Positron Emission Tomography (PET) scanner using an innovative acquisition method based on two rotation axes for the movement of detector pairs. Due to its simplicity, it is suitable for education purposes, to teach students about the PET technology and its basic concepts, from the radiation detecting and analogue pulse analysis to the coincidence sorting and image reconstruction. The concept allows achieving high and uniform position resolution over the whole field of view (FoV), by eliminating parallax errors due to the depth of interaction (DoI), which are typical of ring-based PET systems, so quality images are obtained even without state-of-the-art image reconstruction algorithms. The technology developed at the University of Aveiro with a patent-pending, is licensed to CAEN S.p.A, and included in the educational catalogue of the company. In this work, a simulation toolkit based in the Edugate platform was developed to simulate the EasyPET system. It can simulate all the physical aspects of the product, such us the scanning range, variable Field-of-View (FOV), scintillator energy resolution, coincidence time and energy window, among others. A simple image reconstruction algorithm based on Filtered-back-projection (FBP) is implemented. The toolkit allows a quick analysis in classroom of the simulation results. The platform was also used to study the new EasyPET 3D version, and a simulation of a NEMA NU 4-2008 IQ phantom was performed, demonstrating the capability of the platform not only for education purposes but also for research.Patent Universidade de Aveiro: PCT/IB2016/051487

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The EasyPET: A novel concept for an educational cost-effective positron emission 2D scanner

Cited by 2 publications

References 12 publications

Synthesis and In Vitro Biocompatibility Studies of Novel Alkoxy 4,4-Difluoro-4-bora-3a,4a-diaza-s-indacenes

Synthesis and In Vitro Biocompatibility Studies of Novel Alkoxy 4,4-Difluoro-4-bora-3a,4a-diaza-s-indacenes

An EDUGATE simulation toolkit based on the educational easyPET

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