The EAT–Lancet reference diet and cognitive function across the life course

Kim, Curie; Challinor, Andrew J.; Geurts, Lucie; Gibney, Eileen R.; Galdos, Marcelo Valadares; Fata, Giorgio La; Layé, Sophie; Mathers, John C.; Vauzour, David; Verkuyl, J Martin; Thuret, Sandrine

doi:10.1016/s2542-5196(22)00123-1

Cited by 42 publications

(31 citation statements)

References 95 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Additionally, the change in milk and dairy products intake was not significantly associated with cognitive impairment in this study. Available evidence on the associations between dairy food consumption and cognitive performance is scarce and inconclusive [ 44 ]. Supplementation en Vitamines et Mineraux Antioxidants (SU.VI.MAX) cohorts revealed that total dairy product intake was not associated with cognitive function, and milk consumption was negatively associated with verbal memory performance [ 45 ].…”

Section: Discussionmentioning

confidence: 99%

Association between Changes in Protein Intake and Risk of Cognitive Impairment: A Prospective Cohort Study

Yin

Niu

et al. 2022

Nutrients

View full text Add to dashboard Cite

Little is known about the role of change in protein intake in affecting cognitive function among older adults. Therefore, we aimed to investigate the associations between the change in protein intake from various food groups and cognitive impairment among older adults in a prospective cohort study. A total of 6951 participants without cognitive impairment or dementia were included in this study. The frequency of protein intake from various food groups was measured by a food frequency questionnaire at baseline and follow-up. Multivariable Cox hazard models with time as the underlying time metric applied to calculate the hazard ratios (HRs) and 95% confidence intervals (CIs). During the 37,535 person-years of follow-up, 1202 (17.3%) participants developed cognitive impairment. The improvement in overall protein intake was negatively associated with cognitive impairment with multivariable-adjusted HR of 0.98 (95% CI = 0.97–0.99). Compared with participants with stable change, those with an extreme decline in animal-based protein intake had a 48% higher risk of cognitive impairment. The associations of changes in protein from six food groups with cognitive impairment were in a similar direction to the main result. Protective associations between improving protein intake and a reduced risk of cognitive impairment were observed.

show abstract

Section: Discussionmentioning

confidence: 99%

Association between Changes in Protein Intake and Risk of Cognitive Impairment: A Prospective Cohort Study

Yin

Niu

et al. 2022

Nutrients

View full text Add to dashboard Cite

show abstract

“…The focus of the PH diet consists of an increase in dietary fibre through the consumption of vegetables, fruits, and whole grains, and could thus lead to similar changes within the human gut microbiome as, for example, the Mediterranean Diet or plant-based diet concepts. While the PH diet concept is gaining more and more attention and support from various stakeholders, e.g., pertaining to an improved cognitive function, criticism has been raised about a relative lack of scientific evidence pertaining to its actual health effects [22][23][24]. To shed light on the controversial discussion about the PH diet concept, we aimed to analyse the effects of following the PH diet over the course of twelve weeks on overall biodiversity and gut microbiota composition in contrast to the most prevalent omnivorous diet (OV) and the vegan/vegetarian diet (VV).…”

Section: Introductionmentioning

confidence: 99%

The Effect of a Planetary Health Diet on the Human Gut Microbiome: A Descriptive Analysis

et al. 2023

View full text Add to dashboard Cite

In 2019, researchers from the EAT-Lancet Commission developed the ‘Planetary Health (PH) diet’. Specifically, they provided recommendations pertaining to healthy diets derived from sustainable food systems. Thus far, it has not been analysed how such a diet affects the human intestinal microbiome, which is important for health and disease development. Here, we present longitudinal genome-wide metagenomic sequencing and mass spectrometry data on the gut microbiome of healthy volunteers adhering to the PH diet, as opposed to vegetarian or vegan (VV) and omnivorous (OV) diets. We obtained basic epidemiological information from 41 healthy volunteers and collected stool samples at inclusion and after 2, 4, and 12 weeks. Individuals opting to follow the PH diet received detailed instructions and recipes, whereas individuals in the control groups followed their habitual dietary pattern. Whole-genome DNA was extracted from stool specimens and subjected to shotgun metagenomic sequencing (~3 GB per patient). Conventional bacterial stool cultures were performed in parallel and bacterial species were identified with matrix-assisted laser desorption/ionization time-of-flight (MALDI-TOF) mass spectrometry. We analysed samples from 16 PH, 16 OV, and 9 VV diet patterns. The α-diversity remained relatively stable for all dietary groups. In the PH group, we observed a constant increase from 3.79% at inclusion to 4.9% after 12 weeks in relative abundance of Bifidobacterium adolescentis. Differential PH abundance analysis highlighted a non-significant increase in possible probiotics such as Paraprevotella xylaniphila and Bacteroides clarus. The highest abundance of these bacteria was observed in the VV group. Dietary modifications are associated with rapid alterations to the human gut microbiome, and the PH diet led to a slight increase in probiotic-associated bacteria at ≥4 weeks. Additional research is required to confirm these findings.

show abstract

“…[1] In 2017, the Global Burden of Disease study estimated that dietary risks are responsible for over 10 million deaths DOI: 10.1002/mnfr.202300472 and 250 million disability-adjusted life years, including cardio-metabolic conditions and certain cancers. [2] Although over the last decades, dietary factors have raised interest in a possible role in the cognitive health of older adults, [3] the estimates of the proportion of diseasespecific burden attributable to dietary risk factors are lacking. From an epidemiological point of view, the inclusion of a suboptimal diet as a risk factor for cognitive decline and related dementias would dramatically increase the estimated years lost due to disability for such pathological conditions.…”

Section: Introductionmentioning

confidence: 99%

Dietary (Poly)phenols and Cognitive Decline: A Systematic Review and Meta‐Analysis of Observational Studies

Godos,

Micek,

Mena

et al. 2023

Molecular Nutrition Food Res

View full text Add to dashboard Cite

ScopeThis study aims to systematically review observational studies investigating the relation between dietary (poly)phenol consumption and various cognitive outcomes.Methods and resultsEmbase and PubMed databases are searched from inception to April 2023 for observational studies investigating the relation between dietary (poly)phenol intake and cognitive outcomes. For quantitative analyses, random effects models, subgroup analyses, and dose–response analyses are performed. A total of 37 studies are included in the systematic review. Among (poly)phenols, a higher intake of flavonoids is associated with better cognitive function and lower odds of cognitive decline (although with some exceptions). A quantitative meta‐analysis shows an overall inverse association with cognitive impairment and reduced association with the incidence of dementia or related disorders for total flavonoids (relative risk (RR) = 0.83, 95% confidence interval (CI): 0.76, 0.89), anthocyanins (RR = 0.73, 95% CI: 0.60, 0.89), flavones (RR = 0.77, 95% CI: 0.63, 0.94), flavan‐3‐ols (RR = 0.86, 95% CI: 0.82, 0.91), and flavonols (RR = 0.88, 95% CI: 0.80, 0.96). Data on other (poly)phenolic compounds (i.e., phenolic acids) are promising but too preliminary.ConclusionHabitual inclusion of flavonoids in the diet may play a preventive role against cognitive disorders.

show abstract

The EAT–Lancet reference diet and cognitive function across the life course

Cited by 42 publications

References 95 publications

Association between Changes in Protein Intake and Risk of Cognitive Impairment: A Prospective Cohort Study

Association between Changes in Protein Intake and Risk of Cognitive Impairment: A Prospective Cohort Study

The Effect of a Planetary Health Diet on the Human Gut Microbiome: A Descriptive Analysis

Dietary (Poly)phenols and Cognitive Decline: A Systematic Review and Meta‐Analysis of Observational Studies

Contact Info

Product

Resources

About