The econobiology of pancreatic acinar cells granule inventory and the stealthy nano-machine behind it

Hammel, Ilan; Meilijson, Isaac

doi:10.1016/j.acthis.2015.11.011

Cited by 1 publication

(1 citation statement)

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“…Because of a lack of long-term culture models for Paneth cells that have only been recently resolved (see Section 7 below), the mechanism by which Paneth cells specifically package contents into their granules remains poorly understood. However, general models of regulated vs constitutive secretion in other cell systems likely also apply to Paneth cells [ 14 , 15 , 16 ]. A series of studies have elucidated secreted products, both granule-dependent and independent, that are specific to Paneth cells through a variety of methods including laser capture microdissection and single cell transcriptomics [ 1 , 3 , 7 , 17 , 18 , 19 , 20 , 21 , 22 ].…”

Section: Location and Secretory Function Of Paneth Cellsmentioning

confidence: 99%

Paneth Cells during Viral Infection and Pathogenesis

Holly

Smith

2018

Viruses

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Paneth cells are major secretory cells located in the crypts of Lieberkühn in the small intestine. Our understanding of the diverse roles that Paneth cells play in homeostasis and disease has grown substantially since their discovery over a hundred years ago. Classically, Paneth cells have been characterized as a significant source of antimicrobial peptides and proteins important in host defense and shaping the composition of the commensal microbiota. More recently, Paneth cells have been shown to supply key developmental and homeostatic signals to intestinal stem cells in the crypt base. Paneth cell dysfunction leading to dysbiosis and a compromised epithelial barrier have been implicated in the etiology of Crohn’s disease and susceptibility to enteric bacterial infection. Our understanding of the impact of Paneth cells on viral infection is incomplete. Enteric α-defensins, produced by Paneth cells, can directly alter viral infection. In addition, α-defensins and other antimicrobial Paneth cell products may modulate viral infection indirectly by impacting the microbiome. Here, we discuss recent insights into Paneth cell biology, models to study their function, and the impact, both direct and indirect, of Paneth cells on enteric viral infection.

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